GPR128

{{Short description|Protein-coding gene in the species Homo sapiens}}

G protein-coupled receptor 128 is a protein encoded by the ADGRG7 gene.{{cite web | title = Entrez Gene: GPR128 G protein-coupled receptor 128| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84873}}{{cite journal | vauthors = Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB | title = Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions | journal = FEBS Letters | volume = 531 | issue = 3 | pages = 407–414 | date = November 2002 | pmid = 12435584 | doi = 10.1016/S0014-5793(02)03574-3 | s2cid = 7449692 | doi-access = free | bibcode = 2002FEBSL.531..407F }}{{cite journal | vauthors = Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB | title = International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors | journal = Pharmacological Reviews | volume = 67 | issue = 2 | pages = 338–367 | date = April 2015 | pmid = 25713288 | pmc = 4394687 | doi = 10.1124/pr.114.009647 }} GPR128 is a member of the adhesion GPCR family.{{cite book | author = Stacey M, Yona S | title = Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology) | publisher = Springer | location = Berlin | year = 2011 | isbn = 978-1-4419-7912-4 }}{{cite journal | vauthors = Langenhan T, Aust G, Hamann J | title = Sticky signaling--adhesion class G protein-coupled receptors take the stage | journal = Science Signaling | volume = 6 | issue = 276 | pages = re3 | date = May 2013 | pmid = 23695165 | doi = 10.1126/scisignal.2003825 | s2cid = 6958640 }}

Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.{{cite journal | vauthors = Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT | title = A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis | journal = The EMBO Journal | volume = 31 | issue = 6 | pages = 1364–1378 | date = March 2012 | pmid = 22333914 | pmc = 3321182 | doi = 10.1038/emboj.2012.26 }}

Tissue distribution

GPR128 is specifically expressed in human liver as well as in mouse bone marrow and intestinal tissues.{{cite journal | vauthors = Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB | title = International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors | journal = Pharmacological Reviews | volume = 67 | issue = 2 | pages = 338–367 | date = April 2015 | pmid = 25713288 | pmc = 4394687 | doi = 10.1124/pr.114.009647 }}

Function

Ni et al. showed that Gpr128 deletion in mice causes reduced body weight and induced intestinal contraction frequency.{{cite journal | vauthors = Ni YY, Chen Y, Lu SY, Sun BY, Wang F, Wu XL, Dang SY, Zhang GH, Zhang HX, Kuang Y, Fei J, Gu MM, Rong WF, Wang ZG | title = Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency | journal = World Journal of Gastroenterology | volume = 20 | issue = 2 | pages = 498–508 | date = January 2014 | pmid = 24574718 | pmc = 3923024 | doi = 10.3748/wjg.v20.i2.498 | doi-access = free }}

Clinical significance

A 111-kb copy number gain with breakpoints within the TRK-fused gene (a target of translocations in lymphoma and thyroid tumors) and GPR128 has been identified in the genome of patients with atypical myeloproliferative neoplasms.{{cite journal | vauthors = Chase A, Ernst T, Fiebig A, Collins A, Grand F, Erben P, Reiter A, Schreiber S, Cross NC | title = TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals | journal = Haematologica | volume = 95 | issue = 1 | pages = 20–26 | date = January 2010 | pmid = 19797732 | pmc = 2805730 | doi = 10.3324/haematol.2009.011536 }} Notably, the fused gene was also detected in few healthy individuals.

References

External links

[http://www.adhesiongpcr.org/ Adhesion GPCR consortium]

Category:G protein-coupled receptors