GPR42

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Putative G-protein coupled receptor 42 (previously termed FFAR1L, FFAR3L, GPR41L, and GPR42P) is a protein that in humans is encoded by the GPR42 gene.{{cite journal |vauthors=Sawzdargo M, George SR, Nguyen T, Xu S, Kolakowski LF, O'Dowd BF | title = A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1 | journal = Biochem Biophys Res Commun | volume = 239 | issue = 2 | pages = 543–7 |date=Nov 1997 | pmid = 9344866 | doi = 10.1006/bbrc.1997.7513 }}{{cite web | title = Entrez Gene: GPR42 G protein-coupled receptor 42| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2866}} The human GPR gene is located at the same site as the human FFAR1, FFAR, and FFAR3 genes, i.e., on the long (i.e., "q") arm of chromosome 19 at position 23.33 (notated as 19q23.33). This gene appears to be a segmental duplication of the FFAR3 gene. The human GPR42 gene codes for several proteins with a FFAR3-like structure but their expression in various cell types and tissues as well as their activities and functions have not yet been clearly defined in any scientific publication followed by PubMed as of 2023.{{cite journal | vauthors = Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, Muir AI, Wigglesworth MJ, Kinghorn I, Fraser NJ, Pike NB, Strum JC, Steplewski KM, Murdock PR, Holder JC, Marshall FH, Szekeres PG, Wilson S, Ignar DM, Foord SM, Wise A, Dowell SJ | title = The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids | journal = The Journal of Biological Chemistry | volume = 278 | issue = 13 | pages = 11312–9 | date = March 2003 | pmid = 12496283 | doi = 10.1074/jbc.M211609200 | url = | doi-access = free }}{{cite journal | vauthors = Liaw CW, Connolly DT | title = Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42 | journal = DNA and Cell Biology | volume = 28 | issue = 11 | pages = 555–60 | date = November 2009 | pmid = 19630535 | doi = 10.1089/dna.2009.0916 | url = }}{{cite journal | vauthors = Puhl HL, Won YJ, Lu VB, Ikeda SR | title = Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed | journal = Scientific Reports | volume = 5 | issue = | pages = 12880 | date = August 2015 | pmid = 26260360 | pmc = 4531286 | doi = 10.1038/srep12880 | bibcode = 2015NatSR...512880P | url = }}{{cite journal | vauthors = Pluznick JL | title = Microbial Short-Chain Fatty Acids and Blood Pressure Regulation | journal = Current Hypertension Reports | volume = 19 | issue = 4 | pages = 25 | date = April 2017 | pmid = 28315048 | pmc = 5584783 | doi = 10.1007/s11906-017-0722-5 | url = }}