GPR45
{{short description|Protein-coding gene in humans}}
{{Infobox_gene}}
Probable G-protein coupled receptor 45 is a protein that in humans is encoded by the GPR45 gene.{{cite journal |vauthors=Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF | title = Discovery of three novel orphan G-protein-coupled receptors | journal = Genomics | volume = 56 | issue = 1 | pages = 12–21 |date=May 1999 | pmid = 10036181 | doi = 10.1006/geno.1998.5655 }}{{cite web | title = Entrez Gene: GPR45 G protein-coupled receptor 45| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11250}}
This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system.
References
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Further reading
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- {{cite journal |vauthors=Kawasawa Y, Kume K, Nakade S, etal |title=Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45 |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 3 |pages= 952–6 |year= 2000 |pmid= 11027574 |doi= 10.1006/bbrc.2000.3569 }}
- {{cite journal |vauthors=Kawasawa Y, Kume K, Izumi T, Shimizu T |title=Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 3 |pages= 957–64 |year= 2000 |pmid= 11027575 |doi= 10.1006/bbrc.2000.3570 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |bibcode=2005Natur.434..724H |doi-access= free }}
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{{G protein-coupled receptors}}
Category:G protein-coupled receptors
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