GPR52

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{cs1 config|name-list-style=vanc|display-authors=6}}

{{Infobox_gene}}

Probable G-protein coupled receptor 52 is a protein that in humans is encoded by the GPR52 gene.{{cite journal | vauthors = Sawzdargo M, Nguyen T, Lee DK, Lynch KR, Cheng R, Heng HH, George SR, O'Dowd BF | title = Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain | journal = Brain Research. Molecular Brain Research | volume = 64 | issue = 2 | pages = 193–198 | date = February 1999 | pmid = 9931487 | doi = 10.1016/S0169-328X(98)00277-0 }}{{cite web | title = Entrez Gene: GPR52 G protein-coupled receptor 52 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9293 }}

Members of the G protein-coupled receptor (GPR) family play important roles in signal transduction from the external environment to the inside of the cell.[supplied by OMIM]

Cannabidiol, CBD, and O-1918 are Inverse agonist at GPR52.{{cite journal | vauthors = Stott LA, Brighton CA, Brown J, Mould R, Bennett KA, Newman R, Currinn H, Autore F, Higueruelo AP, Tehan BG, MacSweeney C, O'Brien MA, Watson SP | title = Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918 | journal = Heliyon | volume = 7 | issue = 6 | pages = e07201 | date = June 2021 | pmid = 34189291 | pmc = 8219759 | doi = 10.1016/j.heliyon.2021.e07201 | doi-access = free | bibcode = 2021Heliy...707201S }}