GPR88
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox gene}}
Probable G-protein coupled receptor 88 is a protein that in humans is encoded by the GPR88 gene.{{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}{{cite journal | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-style=vanc| author2=Yoshitomo-Nakagawa K | author3=Maruyama K | display-authors=3 | last4=Suyama | first4=A | last5=Sugano | first5=S }}{{cite journal | author=Mizushima K |title=A novel G-protein-coupled receptor gene expressed in striatum |journal=Genomics |volume=69 |issue= 3 |pages= 314–21 |year= 2001 |pmid= 11056049 |doi= 10.1006/geno.2000.6340 |name-list-style=vanc| author2=Miyamoto Y | author3=Tsukahara F | display-authors=3 | last4=Hirai | first4=Momoki | last5=Sakaki | first5=Yoshiyuki | last6=Ito | first6=Takashi }}{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}{{cite journal |vauthors=Van Waes V, Tseng K, Steiner H |title=GPR88 - a putative signaling molecule predominantly expressed in the striatum: Cellular localization and developmental regulation |journal=Basal Ganglia |volume=1 |issue=2 |pages= 83–89 |year= 2011 |pmid= 21804954 |doi=10.1016/j.baga.2011.04.001 | pmc=3144573 }}
Ligands
;Agonists
- RTI-122Rahman MT, Decker AM, Ben Hamida S, Perrey DA, Chaminda Lakmal HH, Maitra R, Darcq E, Kieffer BL, Jin C. Improvement of the Metabolic Stability of GPR88 Agonist RTI-13951-33: Design, Synthesis, and Biological Evaluation. J Med Chem. 2023 Feb 23;66(4):2964-2978. {{doi|10.1021/acs.jmedchem.2c01983}} {{PMID|36749855}}
References
{{reflist}}
{{G protein-coupled receptors}}
Category:G protein-coupled receptors
{{transmembranereceptor-stub}}