GPRC5A

This gene encodes a member of the type 3 G protein-coupled receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoic acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. Tryptamine and other indole related chemicals produced by gut microflora bind and activate the receptor.{{cite journal |last1=Zhao |first1=Xiaohui |date=2023 |title=Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A |journal=Nature Chemical Biology |volume=19 |issue=10 |pages=1205–1214 |doi=10.1038/s41589-023-01328-z |pmid=37248411}}

GPRC5A is one of only a handful of genes known in the literature that are post-transcriptionally controlled by miRNAs through their 5'UTR.{{cite journal | vauthors = Zhou H, Rigoutsos I | title = MiR-103a-3p targets the 5' UTR of GPRC5A in pancreatic cells | journal = RNA | volume = 20 | issue = 9 | pages = 1431–9 | year = 2014 | pmid = 24984703 | pmc = 4138326 | doi = 10.1261/rna.045757.114 }}

GPRC5A is dysregulated in many human cancers and in other diseases.{{cite journal | vauthors = Zhou H, Rigoutsos I | title = The emerging roles of GPRC5A in diseases | journal = Oncoscience | volume = 1 | issue = 12 | pages = 765–76 | year = 2014 | pmid = 25621293 | pmc = 4303886 | doi = 10.18632/oncoscience.104}}

• Retinoic acid-inducible orphan G protein-coupled receptor

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• {{cite journal | vauthors = Cafferata EG, Gonzalez-Guerrico AM, Pivetta OH, Santa-Coloma TA | title = Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells | journal = Cell. Mol. Biol. (Noisy-le-grand) | volume = 42 | issue = 5 | pages = 797–804 | year = 1996 | pmid = 8832110 }}
• {{cite journal | vauthors = Bräuner-Osborne H, Krogsgaard-Larsen P | title = Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain | journal = Genomics | volume = 65 | issue = 2 | pages = 121–8 | year = 2000 | pmid = 10783259 | doi = 10.1006/geno.2000.6164 }}
• {{cite journal | vauthors = Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN | title = Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C) | journal = Genomics | volume = 67 | issue = 1 | pages = 8–18 | year = 2000 | pmid = 10945465 | doi = 10.1006/geno.2000.6226 }}
• {{cite journal | vauthors = Tao Q, Cheng Y, Clifford J, Lotan R | title = Characterization of the murine orphan G-protein-coupled receptor gene Rai3 and its regulation by retinoic acid | journal = Genomics | volume = 83 | issue = 2 | pages = 270–80 | year = 2004 | pmid = 14706456 | doi = 10.1016/S0888-7543(03)00237-4 }}
• {{cite journal | vauthors = Wu Q, Ding W, Mirza A, Van Arsdale T, Wei I, Bishop WR, Basso A, McClanahan T, Luo L, Kirschmeier P, Gustafson E, Hernandez M, Liu S | title = Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target | journal = J. Biol. Chem. | volume = 280 | issue = 13 | pages = 12935–43 | year = 2005 | pmid = 15659406 | doi = 10.1074/jbc.M409901200 | doi-access = free }}
• {{cite journal | vauthors = Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM | title = Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules | journal = Mol. Cell. Proteomics | volume = 4 | issue = 9 | pages = 1240–50 | year = 2005 | pmid = 15951569 | doi = 10.1074/mcp.M500089-MCP200 | doi-access = free }}
• {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 14 | pages = 5391–6 | year = 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 | bibcode = 2006PNAS..103.5391N | doi-access = free }}
• {{cite journal | vauthors = Hirano M, Zang L, Oka T, Ito Y, Shimada Y, Nishimura Y, Tanaka T | title = Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression | journal = Biochem. Biophys. Res. Commun. | volume = 351 | issue = 1 | pages = 185–91 | year = 2006 | pmid = 17055459 | doi = 10.1016/j.bbrc.2006.10.016 }}
• {{cite journal | vauthors = Mori C, Valdivieso AG, Clauzure M, Massip-Copiz MM, Aguilar MA, Cafferata EG, Santa Coloma TA | title = Identification and characterization of human PEIG-1/GPRC5A as a 12-O-tetradecanoyl phorbol-13-acetate (TPA) and PKC-induced gene | journal = Arch. Biochem. Biophys. | volume = 687 | pages = 108375 | year = 2020 | pmid = 32339486 | doi = 10.1016/j.abb.2020.108375 | s2cid = 216594760 }}

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• {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2959 | title = GPRC5 Receptors: RAIG₁ | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | access-date = 2008-12-04 | archive-date = 2015-02-03 | archive-url = https://web.archive.org/web/20150203220201/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2959 | url-status = dead }}

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{{G protein-coupled receptors|g3}}

Category:G protein-coupled receptors

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