GPRC5D
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{cs1 config|name-list-style=vanc|display-authors=6}}
{{Infobox_gene}}
G-protein coupled receptor family C group 5 member D is a protein that in humans is encoded by the GPRC5D gene.{{cite web | title = Entrez Gene: GPRC5D G protein-coupled receptor, family C, group 5, member D| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55507}} GPRC5D is a class C orphan G protein-coupled receptor predominantly expressed in multiple myeloma cells and hard keratinized tissues, with low expression in normal human tissues, rendering it an appealing target for multiple myeloma cells.{{Cite journal |title=The RAIG family member, GPRC5D, is associated with hard-keratinized structures |journal=J. Invest. Dermatol. |doi=}}{{cite journal | vauthors = Smith EL, Harrington K, Staehr M, Masakayan R, Jones J, Long TJ, Ng KY, Ghoddusi M, Purdon TJ, Wang X, Do T, Pham MT, Brown JM, De Larrea CF, Olson E, Peguero E, Wang P, Liu H, Xu Y, Garrett-Thomson SC, Almo SC, Wendel HG, Riviere I, Liu C, Sather B, Brentjens RJ | title = GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells | journal = Science Translational Medicine | volume = 11 | issue = 485 | date = March 2019 | pmid = 30918115 | pmc = 7508042 | doi = 10.1126/scitranslmed.aau7746 }}{{cite journal | vauthors = Verkleij CP, Broekmans ME, van Duin M, Frerichs KA, Kuiper R, de Jonge AV, Kaiser M, Morgan G, Axel A, Boominathan R, Sendecki J, Wong A, Verona RI, Sonneveld P, Zweegman S, Adams HC, Mutis T, van de Donk NW | title = Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma | journal = Blood Advances | volume = 5 | issue = 8 | pages = 2196–2215 | date = April 2021 | pmid = 33890981 | pmc = 8095149 | doi = 10.1182/bloodadvances.2020003805 }}
Structure
Structural analysis of the complex between GPRC5D and talquetamab, a bispecific antibody for the treatment of multiple myeloma, has revealed that GPRC5D exists as a dimer. GPRC5D forms a symmetric dimer via TM4 and TM4/TM5 interactions. The study further demonstrated that only one talquetamab molecule can bind to the dimeric form of GPRC5D. Talquetamab Fab recognizes ECLs and TM3/5/7 of one GPRC5D protomer via six CDRs. {{cite journal |vauthors=Jeong J, Park J, Young Mo G, Shin J, Cho Y |date=August 2024 |title=Structural Basis for the Recognition of GPRC5D by Talquetamab, a Bispecific Antibody for Multiple Myeloma |url=https://doi.org/10.1016/j.jmb.2024.168748 |journal=Journal of Molecular Biology |volume=436 |issue=20 |pages=168748 |doi=10.1016/j.jmb.2024.168748 |pmid=39181182|url-access=subscription }}
Function
See also
References
{{reflist}}
Further reading
{{refbegin}}
- {{cite journal | vauthors = Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P | title = Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1518 | issue = 3 | pages = 237–248 | date = April 2001 | pmid = 11311935 | doi = 10.1016/s0167-4781(01)00197-x }}
- {{cite journal | vauthors = Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S | title = Identification of G protein-coupled receptor genes from the human genome sequence | journal = FEBS Letters | volume = 520 | issue = 1–3 | pages = 97–101 | date = June 2002 | pmid = 12044878 | doi = 10.1016/S0014-5793(02)02775-8 | s2cid = 7116392 | doi-access = | bibcode = 2002FEBSL.520...97T }}
{{refend}}
{{NLM content}}
{{G protein-coupled receptors|g3}}
Category:G protein-coupled receptors
{{transmembranereceptor-stub}}