GPRC6A
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox gene}}
G protein-coupled receptor family C group 6 member A (GPRC6A) is a protein that in humans is encoded by the GPRC6A gene.{{cite web | title = Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=222545}} This protein functions as a receptor of L-α-amino acids,{{cite journal |vauthors=Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H | title = Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids | journal = Mol. Pharmacol. | volume = 67 | issue = 3 | pages = 589–97 | year = 2005 | pmid = 15576628 | doi = 10.1124/mol.104.007559 | s2cid = 469049 }} cations (e.g., calcium),{{cite journal |vauthors=Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD | title = Identification of a novel extracellular cation-sensing G-protein-coupled receptor | journal = J. Biol. Chem. | volume = 280 | issue = 48 | pages = 40201–9 | date = December 2005 | pmid = 16199532 | pmc = 1435382 | doi = 10.1074/jbc.M505186200 | doi-access = free }} osteocalcin,{{cite journal |vauthors=Pi M, Wu Y, Quarles LD | title = GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo | journal = J. Bone Miner. Res. | volume = 26 | issue = 7 | pages = 1680–3 | date = July 2011 | pmid = 21425331 | doi = 10.1002/jbmr.390 | pmc = 5079536 }} and steroids.{{cite journal |vauthors=Pi M, Parrill AL, Quarles LD | title = GPRC6A mediates the non-genomic effects of steroids | journal = J. Biol. Chem. | volume = 285 | issue = 51 | pages = 39953–64 | date = December 2010 | pmid = 20947496 | pmc = 3000977 | doi = 10.1074/jbc.M110.158063 | doi-access = free }} It is a membrane androgen receptor.
Clinical significance
GPRC6A has also been linked to prostate cancer progression, and it has been shown to mediate rapid, non-genomic prostate cancer cell responses to testosterone.{{cite journal |vauthors=Pi M, Quarles LD | title = GPRC6A regulates prostate cancer progression | journal = Prostate | volume = 72 | issue = 4 | pages = 399–409 | date = June 2011 | pmid = 21681779 | doi = 10.1002/pros.21442 | pmc=3183291}}
See also
References
{{Reflist|2}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M | title = Creation of genome-wide protein expression libraries using random activation of gene expression. | journal = Nat. Biotechnol. | volume = 19 | issue = 5 | pages = 440–5 | year = 2001 | pmid = 11329013 | doi = 10.1038/88107 | s2cid = 25064683 }}
- {{cite journal |vauthors=Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S | title = Identification of G protein-coupled receptor genes from the human genome sequence. | journal = FEBS Lett. | volume = 520 | issue = 1–3 | pages = 97–101 | year = 2002 | pmid = 12044878 | doi = 10.1016/S0014-5793(02)02775-8 | s2cid = 7116392 | doi-access = }}
- {{cite journal |vauthors=Wellendorph P, Bräuner-Osborne H | title = Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor | journal = Gene | volume = 335 | pages = 37–46 | year = 2004 | pmid = 15194188 | doi = 10.1016/j.gene.2004.03.003 }}
- {{cite journal |vauthors=Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H | title = Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids | journal = Mol. Pharmacol. | volume = 67 | issue = 3 | pages = 589–97 | year = 2005 | pmid = 15576628 | doi = 10.1124/mol.104.007559 | s2cid = 469049 }}
- {{cite journal |vauthors=Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD | title = Identification of a novel extracellular cation-sensing G-protein-coupled receptor | journal = J. Biol. Chem. | volume = 280 | issue = 48 | pages = 40201–9 | year = 2006 | pmid = 16199532 | pmc = 1435382 | doi = 10.1074/jbc.M505186200 | doi-access = free }}
{{refend}}
External links
- {{MeshName|GPRC6A+protein,+human}}
- {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2968 | title = Calcium-Sensing Receptors: GPRC6 | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology }}
{{G protein-coupled receptors|g3}}
{{Androgen receptor modulators}}
Category:G protein-coupled receptors
{{transmembranereceptor-stub}}