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GPSM2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

G-protein-signaling modulator 2, also called LGN for its 10 Leucine-Glycine-Asparagine repeats, is a protein that in humans is encoded by the GPSM2 gene.{{cite journal | vauthors = Blumer JB, Chandler LJ, Lanier SM | title = Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis | journal = J. Biol. Chem. | volume = 277 | issue = 18 | pages = 15897–903 | date = Apr 2002 | pmid = 11832491 | doi = 10.1074/jbc.M112185200 | doi-access = free }}{{cite journal | vauthors = Mochizuki N, Cho G, Wen B, Insel PA | title = Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2 | journal = Gene | volume = 181 | issue = 1–2 | pages = 39–43 | year = 1996 | pmid = 8973305 | doi = 10.1016/S0378-1119(96)00456-8 }}{{cite web | title = Entrez Gene: GPSM2 G-protein signalling modulator 2 (AGS3-like, C. elegans)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29899}}

Function

Heterotrimeric G proteins transduce extracellular signals received by cell surface receptors into integrated cellular responses. GPSM2 belongs to a group of proteins that modulate activation of G proteins (Blumer et al., 2002).[supplied by OMIM]

Interactions

GPSM2 has been shown to interact with nuclear mitotic apparatus protein 1{{cite journal | vauthors = Du Q, Stukenberg PT, Macara IG | title = A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization | journal = Nat. Cell Biol. | volume = 3 | issue = 12 | pages = 1069–75 | date = Dec 2001 | pmid = 11781568 | doi = 10.1038/ncb1201-1069 | s2cid = 7955950 }} and GNAI2.{{cite journal | vauthors = Marty C, Browning DD, Ye RD | title = Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras | journal = Mol. Cell. Biol. | volume = 23 | issue = 11 | pages = 3847–58 | date = Jun 2003 | pmid = 12748287 | pmc = 155206 | doi = 10.1128/MCB.23.11.3847-3858.2003 }}

References

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Further reading

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  • {{cite journal | vauthors = Du Q, Stukenberg PT, Macara IG | title = A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization | journal = Nat. Cell Biol. | volume = 3 | issue = 12 | pages = 1069–75 | year = 2001 | pmid = 11781568 | doi = 10.1038/ncb1201-1069 | s2cid = 7955950 }}
  • {{cite journal | vauthors = Marty C, Browning DD, Ye RD | title = Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras | journal = Mol. Cell. Biol. | volume = 23 | issue = 11 | pages = 3847–58 | year = 2003 | pmid = 12748287 | pmc = 155206 | doi = 10.1128/MCB.23.11.3847-3858.2003 }}
  • {{cite journal | vauthors = Kaushik R, Yu F, Chia W, Yang X, Bahri S | title = Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression | journal = Mol. Biol. Cell | volume = 14 | issue = 8 | pages = 3144–55 | year = 2003 | pmid = 12925752 | pmc = 181556 | doi = 10.1091/mbc.E03-04-0212 }}
  • {{cite journal | vauthors = Du Q, Macara IG | title = Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins | journal = Cell | volume = 119 | issue = 4 | pages = 503–16 | year = 2004 | pmid = 15537540 | doi = 10.1016/j.cell.2004.10.028 | s2cid = 12900159 | doi-access = free }}
  • {{cite journal | vauthors = Yasumi M, Sakisaka T, Hoshino T, Kimura T, Sakamoto Y, Yamanaka T, Ohno S, Takai Y | title = Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division | journal = J. Biol. Chem. | volume = 280 | issue = 8 | pages = 6761–5 | year = 2005 | pmid = 15632202 | doi = 10.1074/jbc.C400440200 | doi-access = free }}
  • {{cite journal | vauthors = Yang J, Kamide K, Kokubo Y, Takiuchi S, Tanaka C, Banno M, Miwa Y, Yoshii M, Horio T, Okayama A, Tomoike H, Kawano Y, Miyata T | title = Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population | journal = J. Hypertens. | volume = 23 | issue = 8 | pages = 1497–505 | year = 2005 | pmid = 16003176 | doi = 10.1097/01.hjh.0000174606.41651.ae | s2cid = 21266973 }}
  • {{cite journal | vauthors = Izaki T, Kamakura S, Kohjima M, Sumimoto H | title = Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3 | journal = Biochem. Biophys. Res. Commun. | volume = 341 | issue = 4 | pages = 1001–6 | year = 2006 | pmid = 16458856 | doi = 10.1016/j.bbrc.2006.01.050 }}

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External links

  • {{PDBe-KB2|P81274|Human G-protein-signaling modulator 2}}
  • {{PDBe-KB2|Q8VDU0|Mouse G-protein-signaling modulator 2}}

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