GRIP domain

{{refimprove|date=January 2015}}

{{Infobox protein family

| Symbol = GRIP

| Name = GRIP domain

| image = PDB 1upt EBI.jpg

| width =

| caption = structure of a complex of the golgin-245 grip domain with arl1

| Pfam = PF01465

| Pfam_clan =

| InterPro = IPR000237

| SMART =

| PROSITE =

| MEROPS =

| SCOP = 1upt

| TCDB =

| OPM family =

| OPM protein =

| CAZy =

| CDD =

}}

In molecular biology, the GRIP domain is a conserved protein domain. The GRIP (golgin-97, RanBP2alpha, Imh1p and p230/golgin-245) domain is found in many large coiled-coil proteins. It has been shown to be sufficient for targeting to the Golgi. It contains a completely conserved tyrosine residue.{{cite journal |vauthors=Munro S, Nichols BJ | title = The GRIP domain - a novel Golgi-targeting domain found in several coiled-coil proteins | journal = Curr. Biol. | volume = 9 | issue = 7 | pages = 377–80 |date=April 1999 | pmid = 10209120 | doi = 10.1016/S0960-9822(99)80166-3| s2cid = 14905585 | doi-access = free | bibcode = 1999CBio....9..377M }}{{cite journal | author = Barr FA | title = A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins | journal = Curr. Biol. | volume = 9 | issue = 7 | pages = 381–4 |date=April 1999 | pmid = 10209123 | doi = 10.1016/S0960-9822(99)80167-5| s2cid = 14404566 | doi-access = free | bibcode = 1999CBio....9..381B }}{{cite journal |vauthors=Kjer-Nielsen L, Teasdale RD, van Vliet C, Gleeson PA | title = A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins | journal = Curr. Biol. | volume = 9 | issue = 7 | pages = 385–8 |date=April 1999 | pmid = 10209125 | doi = 10.1016/S0960-9822(99)80168-7| s2cid = 14342088 | doi-access = free | bibcode = 1999CBio....9..385K }}