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GSDMB

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Gasdermin B is a protein that in humans is encoded by the GSDMB gene.

{{cite web

| title = Entrez Gene: Gasdermin B

| url = https://www.ncbi.nlm.nih.gov/gene/55876

| access-date = 2016-08-26

}}

Function

This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding.

Clinical significance

GSDMB expression has been linked to higher survival rates for lung cancer patients.{{cite web|url=https://www.worldcommunitygrid.org/about_us/article.s?articleId=797|publisher=World Community Grid|title=MCM team has been researching GSDMB|date=12 July 2023|access-date=20 September 2024}}

References

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Further reading

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  • {{cite journal |vauthors=Katoh M, Katoh M |title=Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon |journal=Int. J. Oncol. |volume=24 |issue=4 |pages=757–63 |year=2004 |pmid=15010812 |doi= 10.3892/ijo.24.4.757}}

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