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GSPT2

{{Short description|Protein-coding gene in humans}}

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Eukaryotic peptide chain release factor GTP-binding subunit ERF3B is an enzyme that in humans is encoded by the GSPT2 gene.{{cite journal |vauthors=Hansen LL, Jakobsen CG, Justesen J | title = Assignment of the human peptide chain release factor 3 (GSPT2) to Xp11.23→p11.21 and of the distal marker DXS1039 by radiation hybrid mapping | journal = Cytogenet Cell Genet | volume = 86 | issue = 3–4 | pages = 250–1 |date=Jan 2000 | pmid = 10575220 | doi =10.1159/000015353 | s2cid = 44348876 }}{{cite web | title = Entrez Gene: GSPT2 G1 to S phase transition 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23708}}

GSPT2 is closely related to GSPT1 (MIM 139259), a GTP-binding protein that plays an essential role at the G1- to S-phase transition of the cell cycle in yeast and human cells. GSPT1 is a positive regulator of translational accuracy and, in a binary complex with eRF1 (MIM 600285), functions as a polypeptide chain release factor.[supplied by OMIM]

Interactions

GSPT2 has been shown to interact with PABPC1.{{cite journal |last=Hoshino |first=S |author2=Imai M |author3=Kobayashi T |author4=Uchida N |author5=Katada T |date=Jun 1999 |title=The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein |journal=J. Biol. Chem. |volume=274 |issue=24 |pages=16677–80 |location = UNITED STATES| issn = 0021-9258| pmid = 10358005 |doi=10.1074/jbc.274.24.16677 |doi-access=free }}

References

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Further reading

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  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
  • {{cite journal |vauthors=Chauvin C, Salhi S, Le Goff C, etal |title=Involvement of Human Release Factors eRF3a and eRF3b in Translation Termination and Regulation of the Termination Complex Formation |journal=Mol. Cell. Biol. |volume=25 |issue= 14 |pages= 5801–11 |year= 2005 |pmid= 15987998 |doi= 10.1128/MCB.25.14.5801-5811.2005 | pmc=1168810 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Le Goff C, Zemlyanko O, Moskalenko S, etal |title=Mouse GSPT2, but not GSPT1, can substitute for yeast eRF3 in vivo |journal=Genes Cells |volume=7 |issue= 10 |pages= 1043–57 |year= 2003 |pmid= 12354098 |doi=10.1046/j.1365-2443.2002.00585.x |doi-access=free }}
  • {{cite journal |vauthors=Hoshino S, Imai M, Kobayashi T, etal |title=The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 16677–80 |year= 1999 |pmid= 10358005 |doi=10.1074/jbc.274.24.16677 |doi-access=free }}
  • {{cite journal |vauthors=Hoshino S, Imai M, Mizutani M, etal |title=Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1 |journal=J. Biol. Chem. |volume=273 |issue= 35 |pages= 22254–9 |year= 1998 |pmid= 9712840 |doi=10.1074/jbc.273.35.22254 |doi-access= free}}

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External links

  • {{PDBe-KB2|Q8IYD1|Human Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (GSPT2)}}

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