GTF3A

{{Short description|Protein-coding gene in the species Homo sapiens}}

Transcription factor IIIA is a protein that in humans is encoded by the GTF3A gene. {{cite journal | vauthors = Arakawa H, Nagase H, Hayashi N, Ogawa M, Nagata M, Fujiwara T, Takahashi E, Shin S, Nakamura Y | display-authors = 6 | title = Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA | journal = Cytogenetics and Cell Genetics | volume = 70 | issue = 3–4 | pages = 235–8 | date = Jul 1995 | pmid = 7789179 | doi = 10.1159/000134041 }}{{cite web | title = Entrez Gene: GTF3A general transcription factor IIIA| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2971}}

It was first purified and identified as the first mammalian gene-specific activator by Robert G. Roeder in 1980,{{cite journal |vauthors=Engelke DR, Ng SY, Shastry BS, Roeder RG | title = Specific interaction of a purified transcription factor with an internal control region of 5S RNA genes | journal = Cell | volume = 19 | issue = 3 | pages = 717–28 |date=Mar 1980 | pmid = 6153931 | doi =10.1016/S0092-8674(80)80048-1 | s2cid = 23955175 }} and later characterized by Wolffe and Brown in 1988.

The TFIIIA in Xenopus was the first zinc finger protein discovered.{{cite journal | vauthors = Bruno M, Mahgoub M, Macfarlan TS | title = The Arms Race Between KRAB-Zinc Finger Proteins and Endogenous Retroelements and Its Impact on Mammals | journal = Annual Review of Genetics | volume = 53 | issue = 1 | pages = 393–416 | date = December 2019 | pmid = 31518518 | doi = 10.1146/annurev-genet-112618-043717 | publisher = Annual Reviews | s2cid = 202572327 }}

References

{{cite journal |vauthors=Engelke DR, Ng SY, Shastry BS, Roeder RG | title = Specific interaction of a purified transcription factor with an internal control region of 5S RNA genes | journal = Cell | volume = 19 | issue = 3 | pages = 717–28 |date=Mar 1980 | pmid = 6153931 | doi =10.1016/S0092-8674(80)80048-1 | s2cid = 23955175 }}
{{cite journal | vauthors = Murphy JE, Keen JH | title = Recognition sites for clathrin-associated proteins AP-2 and AP-3 on clathrin triskelia | journal = The Journal of Biological Chemistry | volume = 267 | issue = 15 | pages = 10850–5 | date = May 1992 | pmid = 1587861 | doi = 10.1016/S0021-9258(19)50096-5 | doi-access = free }}
{{cite journal | vauthors = Seifart KH, Wang L, Waldschmidt R, Jahn D, Wingender E | title = Purification of human transcription factor IIIA and its interaction with a chemically synthesized gene encoding human 5 S rRNA | journal = The Journal of Biological Chemistry | volume = 264 | issue = 3 | pages = 1702–9 | date = January 1989 | pmid = 2912980 | doi = 10.1016/S0021-9258(18)94243-2 | doi-access = free }}
{{cite journal | vauthors = Drew PD, Nagle JW, Canning RD, Ozato K, Biddison WE, Becker KG | title = Cloning and expression analysis of a human cDNA homologous to Xenopus TFIIIA | journal = Gene | volume = 159 | issue = 2 | pages = 215–8 | date = July 1995 | pmid = 7622052 | doi = 10.1016/0378-1119(95)00145-V }}
{{cite journal | vauthors = Moorefield B, Roeder RG | title = Purification and characterization of human transcription factor IIIA | journal = The Journal of Biological Chemistry | volume = 269 | issue = 33 | pages = 20857–65 | date = August 1994 | pmid = 8063702 | doi = 10.1016/S0021-9258(17)31901-4 | doi-access = free }}
{{cite journal | vauthors = Fridell RA, Fischer U, Lührmann R, Meyer BE, Meinkoth JL, Malim MH, Cullen BR | title = Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 7 | pages = 2936–40 | date = April 1996 | pmid = 8610146 | pmc = 39738 | doi = 10.1073/pnas.93.7.2936 | bibcode = 1996PNAS...93.2936F | doi-access = free }}
{{cite journal | vauthors = Oettel S, Härtel F, Kober I, Iben S, Seifart KH | title = Human transcription factors IIIC2, IIIC1 and a novel component IIIC0 fulfil different aspects of DNA binding to various pol III genes | journal = Nucleic Acids Research | volume = 25 | issue = 12 | pages = 2440–7 | date = June 1997 | pmid = 9171097 | pmc = 146769 | doi = 10.1093/nar/25.12.2440 }}
{{cite journal | vauthors = Moreland RJ, Dresser ME, Rodgers JS, Roe BA, Conaway JW, Conaway RC, Hanas JS | title = Identification of a transcription factor IIIA-interacting protein | journal = Nucleic Acids Research | volume = 28 | issue = 9 | pages = 1986–93 | date = May 2000 | pmid = 10756201 | pmc = 103300 | doi = 10.1093/nar/28.9.1986 }}
{{cite journal | vauthors = Rao DS, Chang JC, Kumar PD, Mizukami I, Smithson GM, Bradley SV, Parlow AF, Ross TS | display-authors = 6 | title = Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors | journal = Molecular and Cellular Biology | volume = 21 | issue = 22 | pages = 7796–806 | date = November 2001 | pmid = 11604514 | pmc = 99949 | doi = 10.1128/MCB.21.22.7796-7806.2001 }}
{{cite journal | vauthors = Hanas JS, Hocker JR, Cheng YG, Lerner MR, Brackett DJ, Lightfoot SA, Hanas RJ, Madhusudhan KT, Moreland RJ | display-authors = 6 | title = cDNA cloning, DNA binding, and evolution of mammalian transcription factor IIIA | journal = Gene | volume = 282 | issue = 1–2 | pages = 43–52 | date = January 2002 | pmid = 11814676 | doi = 10.1016/S0378-1119(01)00796-X }}
{{cite journal | vauthors = Weser S, Riemann J, Seifart KH, Meissner W | title = Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA gene | journal = Nucleic Acids Research | volume = 31 | issue = 9 | pages = 2408–16 | date = May 2003 | pmid = 12711686 | pmc = 154231 | doi = 10.1093/nar/gkg345 }}
{{cite journal | vauthors = Pellikainen JM, Ropponen KM, Kataja VV, Kellokoski JK, Eskelinen MJ, Kosma VM | title = Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in breast cancer with a special reference to activator protein-2, HER2, and prognosis | journal = Clinical Cancer Research | volume = 10 | issue = 22 | pages = 7621–8 | date = November 2004 | pmid = 15569994 | doi = 10.1158/1078-0432.CCR-04-1061 | doi-access = free }}
{{cite journal | vauthors = Paing MM, Johnston CA, Siderovski DP, Trejo J | title = Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization | journal = Molecular and Cellular Biology | volume = 26 | issue = 8 | pages = 3231–42 | date = April 2006 | pmid = 16581796 | pmc = 1446942 | doi = 10.1128/MCB.26.8.3231-3242.2006 }}
{{cite journal | vauthors = Yamashita A, Takada T, Nemoto K, Yamamoto G, Torii R | title = Transient suppression of PPARgamma directed ES cells into an osteoblastic lineage | journal = FEBS Letters | volume = 580 | issue = 17 | pages = 4121–5 | date = July 2006 | pmid = 16828750 | doi = 10.1016/j.febslet.2006.06.057 | bibcode = 2006FEBSL.580.4121Y | s2cid = 84554520 }}
{{cite journal | vauthors = Schwartz B, Melnikova VO, Tellez C, Mourad-Zeidan A, Blehm K, Zhao YJ, McCarty M, Adam L, Bar-Eli M | display-authors = 6 | title = Loss of AP-2alpha results in deregulation of E-cadherin and MMP-9 and an increase in tumorigenicity of colon cancer cells in vivo | journal = Oncogene | volume = 26 | issue = 28 | pages = 4049–58 | date = June 2007 | pmid = 17224907 | doi = 10.1038/sj.onc.1210193 | doi-access = free }}

External links

{{MeshName|GTF3A+protein,+human}}

Category:Transcription factors

GTF3A

References

Further reading

External links