GZMM
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Granzyme M is a protein that in humans is encoded by the GZMM gene.{{cite journal |vauthors=Baker E, Sutherland GR, Smyth MJ |authorlink2=Grant Robert Sutherland | title = The gene encoding a human natural killer cell granule serine protease, Met-ase 1, maps to chromosome 19p13.3 | journal = Immunogenetics | volume = 39 | issue = 4 | pages = 294–5 |date=Apr 1994 | pmid = 8119738 | doi = 10.1007/bf00188796| s2cid = 33990020 }}{{cite web | title = Entrez Gene: GZMM granzyme M (lymphocyte met-ase 1)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3004}}
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and Met-ase, also known as granzyme M.{{cite web | title = Entrez Gene: GZMM granzyme M (lymphocyte met-ase 1)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3004}}
References
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Further reading
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- {{cite journal |vauthors=Smyth MJ, O'Connor MD, Trapani JA |title=Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies. |journal=J. Leukoc. Biol. |volume=60 |issue= 5 |pages= 555–62 |year= 1996 |pmid= 8929545 |doi= 10.1002/jlb.60.5.555|s2cid=19732623 }}
- {{cite journal |vauthors=Pilat D, Fink T, Obermaier-Skrobanek B, etal |title=The human Met-ase gene (GZMM): structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3. |journal=Genomics |volume=24 |issue= 3 |pages= 445–50 |year= 1995 |pmid= 7713495 |doi= 10.1006/geno.1994.1651 }}
- {{cite journal |vauthors=Smyth MJ, Sayers TJ, Wiltrout T, etal |title=Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells. |journal=J. Immunol. |volume=151 |issue= 11 |pages= 6195–205 |year= 1994 |doi=10.4049/jimmunol.151.11.6195 |pmid= 8245461 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Krenacs L, Smyth MJ, Bagdi E, etal |title=The serine protease granzyme M is preferentially expressed in NK-cell, gamma delta T-cell, and intestinal T-cell lymphomas: evidence of origin from lymphocytes involved in innate immunity. |journal=Blood |volume=101 |issue= 9 |pages= 3590–3 |year= 2003 |pmid= 12506019 |doi= 10.1182/blood-2002-09-2908 |doi-access= free }}
- {{cite journal |vauthors=Kelly JM, Waterhouse NJ, Cretney E, etal |title=Granzyme M mediates a novel form of perforin-dependent cell death. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22236–42 |year= 2004 |pmid= 15028722 |doi= 10.1074/jbc.M401670200 |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Mahrus S, Kisiel W, Craik CS |title=Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B. |journal=J. Biol. Chem. |volume=279 |issue= 52 |pages= 54275–82 |year= 2005 |pmid= 15494398 |doi= 10.1074/jbc.M411482200 |doi-access= free }}
- {{cite journal |vauthors=Lu H, Hou Q, Zhao T, etal |title=Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation. |journal=J. Immunol. |volume=177 |issue= 2 |pages= 1171–8 |year= 2006 |pmid= 16818775 |doi= 10.4049/jimmunol.177.2.1171|doi-access=free }}
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