G protein nucleolar 3 like
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
G protein nucleolar 3 like is a protein that in humans is encoded by the GNL3L gene.
{{cite web
| title = Entrez Gene: G protein nucleolar 3 like
| url = https://www.ncbi.nlm.nih.gov/gene/54552
| access-date = 2017-10-23
}}
Function
The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene.
References
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Further reading
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- {{cite journal |vauthors=Du X, Rao MR, Chen XQ, Wu W, Mahalingam S, Balasundaram D |title=The homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA |journal=Mol. Biol. Cell |volume=17 |issue=1 |pages=460–74 |year=2006 |pmid=16251348 |pmc=1345682 |doi=10.1091/mbc.E05-09-0848 }}
- {{cite journal |vauthors=Rao MR, Kumari G, Balasundaram D, Sankaranarayanan R, Mahalingam S |title=A novel lysine-rich domain and GTP binding motifs regulate the nucleolar retention of human guanine nucleotide binding protein, GNL3L |journal=J. Mol. Biol. |volume=364 |issue=4 |pages=637–54 |year=2006 |pmid=17034816 |doi=10.1016/j.jmb.2006.09.007 }}
- {{cite journal |vauthors=Oktar PA, Yildirim S, Balci D, Can A |title=Continual expression throughout the cell cycle and downregulation upon adipogenic differentiation makes nucleostemin a vital human MSC proliferation marker |journal=Stem Cell Rev |volume=7 |issue=2 |pages=413–24 |year=2011 |pmid=21063916 |doi=10.1007/s12015-010-9201-y |s2cid=1002010 }}
- {{cite journal |vauthors=Meng L, Hsu JK, Tsai RY |title=GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest |journal=Oncogene |volume=30 |issue=14 |pages=1716–26 |year=2011 |pmid=21132010 |pmc=3072457 |doi=10.1038/onc.2010.550 }}
- {{cite journal |vauthors=Lin T, Meng L, Lin TC, Wu LJ, Pederson T, Tsai RY |title=Nucleostemin and GNL3L exercise distinct functions in genome protection and ribosome synthesis, respectively |journal=J. Cell Sci. |volume=127 |issue=Pt 10 |pages=2302–12 |year=2014 |pmid=24610951 |doi=10.1242/jcs.143842 |pmc=6519424}}
- {{cite journal |vauthors=Thoompumkal IJ, Subba Rao MR, Kumaraswamy A, Krishnan R, Mahalingam S |title=GNL3L Is a Nucleo-Cytoplasmic Shuttling Protein: Role in Cell Cycle Regulation |journal=PLOS ONE |volume=10 |issue=8 |pages=e0135845 |year=2015 |pmid=26274615 |pmc=4537249 |doi=10.1371/journal.pone.0135845 |bibcode=2015PLoSO..1035845T |doi-access=free }}
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