Galanin receptor 1

The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-trans membrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the GI/GO family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.

• Galanin receptor

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• {{cite journal | vauthors = Habert-Ortoli E, Amiranoff B, Loquet I, Laburthe M, Mayaux JF | title = Molecular cloning of a functional human galanin receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 21 | pages = 9780–3 | date = Oct 1994 | pmid = 7524088 | pmc = 44900 | doi = 10.1073/pnas.91.21.9780 | doi-access = free | bibcode = 1994PNAS...91.9780H }}
• {{cite journal | vauthors = Walli R, Schäfer H, Morys-Wortmann C, Paetzold G, Nustede R, Schmidt WE | title = Identification and biochemical characterization of the human brain galanin receptor | journal = Journal of Molecular Endocrinology | volume = 13 | issue = 3 | pages = 347–56 | date = Dec 1994 | pmid = 7534460 | doi = 10.1677/jme.0.0130347 }}
• {{cite journal | vauthors = Kask K, Berthold M, Kahl U, Nordvall G, Bartfai T | title = Delineation of the peptide binding site of the human galanin receptor | journal = The EMBO Journal | volume = 15 | issue = 2 | pages = 236–44 | date = Jan 1996 | pmid = 8617199 | pmc = 449938 | doi = 10.1002/j.1460-2075.1996.tb00354.x}}
• {{cite journal | vauthors = Lorimer DD, Benya RV | title = Cloning and quantification of galanin-1 receptor expression by mucosal cells lining the human gastrointestinal tract | journal = Biochemical and Biophysical Research Communications | volume = 222 | issue = 2 | pages = 379–85 | date = May 1996 | pmid = 8670213 | doi = 10.1006/bbrc.1996.0752 }}
• {{cite journal | vauthors = Nicholl J, Kofler B, Sutherland GR, Shine J, Iismaa TP |authorlink3=Grant Robert Sutherland | title = Assignment of the gene encoding human galanin receptor (GALNR) to 18q23 by in situ hybridization | journal = Genomics | volume = 30 | issue = 3 | pages = 629–30 | date = Dec 1995 | pmid = 8825658 | doi = 10.1006/geno.1995.1292 }}
• {{cite journal | vauthors = Sullivan KA, Shiao LL, Cascieri MA | title = Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors | journal = Biochemical and Biophysical Research Communications | volume = 233 | issue = 3 | pages = 823–8 | date = Apr 1997 | pmid = 9168941 | doi = 10.1006/bbrc.1997.6542 }}
• {{cite journal | vauthors = Jacoby AS, Webb GC, Liu ML, Kofler B, Hort YJ, Fathi Z, Bottema CD, Shine J, Iismaa TP | title = Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene | journal = Genomics | volume = 45 | issue = 3 | pages = 496–508 | date = Nov 1997 | pmid = 9367674 | doi = 10.1006/geno.1997.4960 }}
• {{cite journal | vauthors = Lorimer DD, Matkowskj K, Benya RV | title = Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R) | journal = Biochemical and Biophysical Research Communications | volume = 241 | issue = 2 | pages = 558–64 | date = Dec 1997 | pmid = 9425310 | doi = 10.1006/bbrc.1997.7838 }}
• {{cite journal | vauthors = Fitzgerald LW, Patterson JP, Conklin DS, Horlick R, Largent BL | title = Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 287 | issue = 2 | pages = 448–56 | date = Nov 1998 | pmid = 9808667 }}
• {{cite journal | vauthors = Henson BS, Neubig RR, Jang I, Ogawa T, Zhang Z, Carey TE, D'Silva NJ | title = Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma | journal = The Journal of Biological Chemistry | volume = 280 | issue = 24 | pages = 22564–71 | date = Jun 2005 | pmid = 15767248 | doi = 10.1074/jbc.M414589200 | doi-access = free }}
• {{cite journal | vauthors = Schäuble N, Reichwald K, Grassl W, Bechstein H, Müller HC, Scherag A, Geller F, Utting M, Siegfried W, Goldschmidt H, Blundell J, Lawton C, Alam R, Whybrow S, Stubbs J, Platzer M, Hebebrand J, Hinney A | title = Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity | journal = The Journal of Nutrition | volume = 135 | issue = 6 | pages = 1387–92 | date = Jun 2005 | pmid = 15930442 | doi = 10.1093/jn/135.6.1387| doi-access = free }}
• {{cite journal | vauthors = Belfer I, Hipp H, Bollettino A, McKnight C, Evans C, Virkkunen M, Albaugh B, Max MB, Goldman D, Enoch MA | title = Alcoholism is associated with GALR3 but not two other galanin receptor genes | journal = Genes, Brain and Behavior | volume = 6 | issue = 5 | pages = 473–81 | date = Jul 2007 | pmid = 17083333 | doi = 10.1111/j.1601-183X.2006.00275.x | s2cid = 20809912 | doi-access = free }}

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• {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2981 | title = Galanin Receptors: GAL₁ | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology }}

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{{G protein-coupled receptors|g1}}

Category:G protein-coupled receptors

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sr:Galaninski receptor 3