Gastrokine-1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Gastrokine-1 is a protein that in humans is encoded by the GKN1 gene.{{cite journal | vauthors = Martin TE, Powell CT, Wang Z, Bhattacharyya S, Walsh-Reitz MM, Agarwal K, Toback FG | title = A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa | journal = American Journal of Physiology. Gastrointestinal and Liver Physiology | volume = 285 | issue = 2 | pages = G332-43 | date = August 2003 | pmid = 12851218 | doi = 10.1152/ajpgi.00453.2002 | s2cid = 2860022 | url = http://pdfs.semanticscholar.org/9c7e/d2ad52d32efc8e92507716d7c827be6766fb.pdf | archive-url = https://web.archive.org/web/20190302130618/http://pdfs.semanticscholar.org/9c7e/d2ad52d32efc8e92507716d7c827be6766fb.pdf | url-status = dead | archive-date = 2019-03-02 }}{{cite journal | vauthors = Shiozaki K, Nakamori S, Tsujie M, Okami J, Yamamoto H, Nagano H, Dono K, Umeshita K, Sakon M, Furukawa H, Hiratsuka M, Kasugai T, Ishiguro S, Monden M | display-authors = 6 | title = Human stomach-specific gene, CA11, is down-regulated in gastric cancer | journal = International Journal of Oncology | volume = 19 | issue = 4 | pages = 701–7 | date = October 2001 | pmid = 11562744 | doi = 10.3892/ijo.19.4.701 }}{{cite web | title = Entrez Gene: GKN1 gastrokine 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56287}}
The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa.
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors = Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I | title = Isolation of two novel genes, down-regulated in gastric cancer | journal = Japanese Journal of Cancer Research | volume = 91 | issue = 5 | pages = 459–63 | date = May 2000 | pmid = 10835488 | pmc = 5926377 | doi = 10.1111/j.1349-7006.2000.tb00967.x }}
- {{cite journal | vauthors = Westley BR, Griffin SM, May FE | title = Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C | journal = Biochemistry | volume = 44 | issue = 22 | pages = 7967–75 | date = June 2005 | pmid = 15924415 | doi = 10.1021/bi047287n }}
- {{cite journal | vauthors = Walsh-Reitz MM, Huang EF, Musch MW, Chang EB, Martin TE, Kartha S, Toback FG | title = AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins | journal = American Journal of Physiology. Gastrointestinal and Liver Physiology | volume = 289 | issue = 1 | pages = G163-71 | date = July 2005 | pmid = 15961882 | pmc = 1444946 | doi = 10.1152/ajpgi.00013.2005 }}
- {{cite journal | vauthors = Nardone G, Rippa E, Martin G, Rocco A, Siciliano RA, Fiengo A, Cacace G, Malorni A, Budillon G, Arcari P | display-authors = 6 | title = Gastrokine 1 expression in patients with and without Helicobacter pylori infection | journal = Digestive and Liver Disease | volume = 39 | issue = 2 | pages = 122–9 | date = February 2007 | pmid = 17092786 | doi = 10.1016/j.dld.2006.09.017 }}
{{refend}}
{{gene-2-stub}}