Generalized essential telangiectasia

Generalized essential telangiectasia is defined by the appearance of extensive telangiectases on the skin, which gradually extend to other parts of the body over time.{{cite journal | last1=Spratt | first1=Elizabeth A Gordon | last2=DeFelice | first2=Taylor | last3=O'Reilly | first3=Kathryn | last4=Robinson | first4=Maria | last5=Patel | first5=Rishi R | last6=Sanchez | first6=Miguel | title=Generalized essential telangiectasia | journal=Dermatology Online Journal | volume=18 | issue=12 | date=2012-12-01 | issn=1087-2108 | doi=10.5070/D30HX273P5 | page=}} Usually, lesions start in the lower limbs and work their way up to the upper torso.{{cite journal | last1=Long | first1=Dorota | last2=Marshman | first2=Gillian | title=Generalized essential telangiectasia | journal=Australasian Journal of Dermatology | publisher=Wiley | volume=45 | issue=1 | year=2004 | issn=0004-8380 | doi=10.1111/j.1440-0960.2004.00033.x | pages=67–69| pmid=14961914 }} Lesions can be diffuse or confined, discrete or confluent, and have a pattern resembling that of a macular or plaque.{{cite journal | last=McGrae | first=John D. | title=Generalized Essential Telangiectasia: Report of a Clinical and Histochemical Study of 13 Patients with Acquired Cutaneous Lesions | journal=JAMA | volume=185 | issue=12 | date=1963-09-21 | pages=909–913 | issn=0098-7484 | doi=10.1001/jama.1963.03060120019015 | pmid=14044221 }} The eruption rarely causes any symptoms. But it's possible to experience burning, tingling, numbness, or moderate pruritus. Although mucosal involvement is rare, conjunctival and/or oral mucosal telangiectases have been observed in some cases.{{cite journal | last1=Ali | first1=M. M. | last2=Teimory | first2=M. | last3=Sarhan | first3=M. | title=Generalized essential telangiectasia with conjunctival involvement | journal=Clinical and Experimental Dermatology | publisher=Oxford University Press (OUP) | volume=31 | issue=6 | year=2006 | issn=0307-6938 | doi=10.1111/j.1365-2230.2006.02217.x | pages=781–782| pmid=17040263 }}

The exact cause of generalized essential telangiectasia is uncertain.{{cite journal | last1=Matthews | first1=Stephanie | last2=Dallo | first2=Christopher | last3=Tate | first3=Jesalyn | title=Generalized Essential Telangiectasia | journal=JAMA Dermatology | volume=159 | issue=6 | date=2023-06-01 | issn=2168-6068 | doi=10.1001/jamadermatol.2022.6229 | page=661| pmid=37074704 }} The lower legs and feet are more likely to have lesions, leading to the hypothesis that gravity and hydrostatic pressures are related. According to one author, a case of generalized essential telangiectasia might have been caused by a vitamin C deficiency brought on by a colitis-related restrictive diet, which resulted in a down-regulation of collagen formation.{{cite journal | last1=Karen | first1=Julie K | last2=Mengden | first2=Stephanie J | last3=Kamino | first3=Hideko | last4=Shupack | first4=Jerome L | title=Generalized essential telangiectasia | journal=Dermatology Online Journal | volume=14 | issue=5 | date=2008 | issn=1087-2108 | doi=10.5070/D36DD8M6RK | page=| pmid=18627745 }}

Generalized essential telangiectasia is a clinical diagnosis made after ruling out systemic sources of telangiectases. Differential diagnosis includes cirrhosis, syphilis, hereditary haemorrhagic telangiectasia, ataxia telangiectasia syndrome, telangiectasia macularis eruptiva perstans, medications, telangiectases associated with autoimmune diseases (dermatomyositis, systemic lupus erythematosus, and systemic sclerosis), and previous radiation therapy.{{cite journal | last1=Tetart | first1=F. | last2=Lorthioir | first2=A. | last3=Girszyn | first3=N. | last4=Lahaxe | first4=L. | last5=Ducrotté | first5=P. | last6=Marie | first6=I. | title=Watermelon stomach revealing generalized essential telangiectasia | journal=Internal Medicine Journal | publisher=Wiley | volume=39 | issue=11 | year=2009 | issn=1444-0903 | doi=10.1111/j.1445-5994.2009.02048.x | pages=781–783| pmid=19912409 }}

Unless the patient requests treatment to improve the appearance of the lesions, supportive care alone is sufficient.{{cite journal | last1=Powell | first1=Emily | last2=Markus | first2=Ramsey | last3=Malone | first3=Cedar H. | title=Generalized essential telangiectasia treated with PDL | journal=Journal of Cosmetic Dermatology | publisher=Wiley | volume=20 | issue=4 | date=2021-01-16 | issn=1473-2130 | doi=10.1111/jocd.13938 | pages=1086–1087| pmid=33405306 }} Compression stockings, minocycline, or vascular laser therapy are available as treatment options.

• Skin lesion
• List of cutaneous conditions

{{reflist}}

• {{cite journal | last1=Gambichler | first1=Thilo | last2=Avermaete | first2=Annelies | last3=Wilmert | first3=Monika | last4=Altmeyer | first4=Peter | last5=Hoffmann | first5=Klaus | title=Generalized Essential Telangiectasia Successfully Treated with High-Energy, Long-Pulse, Frequency-Doubled Nd:YAG Laser | journal=Dermatologic Surgery | publisher=Ovid Technologies (Wolters Kluwer Health) | volume=27 | issue=4 | year=2001 | issn=1076-0512 | doi=10.1046/j.1524-4725.2001.00307.x | pages=355–357 | pmid=11298706 | ref=none}}
• {{cite journal | last1=Thieu | first1=Khanh P. | last2=Haynes | first2=Harley A. | title=Generalized essential telangiectasia with predilection for surgical scar | journal=Journal of the American Academy of Dermatology | publisher=Elsevier BV | volume=60 | issue=4 | year=2009 | issn=0190-9622 | doi=10.1016/j.jaad.2008.09.025 | pages=710–711 | pmid=19293028 | ref=none}}

• [https://dermnetnz.org/topics/generalised-essential-telangiectasia DermNet]
• [https://www.visualdx.com/visualdx/diagnosis/generalized+essential+telangiectasia?diagnosisId=53273&moduleId=101 VisualDx]

{{Medical resources

| ICD11 = {{ICD11|EF20.4}}

| ICD10 = {{ICD10|L98.8}}

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| OMIM = 187260

| MeshID = C562998

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| eMedicineTopic = 1083313

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| Scholia = Q5532473

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Category:Dermal and subcutaneous growths

Category:Vascular-related cutaneous conditions

{{Vascular diseases}}