Geneva score
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| purpose = pre-test probability of Venous Thrombo Embolism =
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The Geneva score is a clinical prediction rule used in determining the pre-test probability of pulmonary embolism (PE) based on a patient's risk factors and clinical findings.{{cite journal | vauthors = Wicki J, Perneger TV, Junod AF, Bounameaux H, Perrier A | title = Assessing clinical probability of pulmonary embolism in the emergency ward: a simple score | journal = Archives of Internal Medicine | volume = 161 | issue = 1 | pages = 92–97 | date = January 2001 | pmid = 11146703 | doi = 10.1001/archinte.161.1.92 | doi-access = free }} It has been shown to be as accurate as the Wells Score, and is less reliant on the experience of the doctor applying the rule.{{cite journal | vauthors = Iles S, Hodges AM, Darley JR, Frampton C, Epton M, Beckert LE, Town GI | title = Clinical experience and pre-test probability scores in the diagnosis of pulmonary embolism | journal = QJM | volume = 96 | issue = 3 | pages = 211–215 | date = March 2003 | pmid = 12615985 | doi = 10.1093/qjmed/hcg027 | doi-access = free }} The Geneva score has been revised and simplified from its original version. The simplified Geneva score is the newest version for the general population, and predicted to have the same diagnostic utility as the original Geneva score.{{cite journal | vauthors = Klok FA, Mos IC, Nijkeuter M, Righini M, Perrier A, Le Gal G, Huisman MV | title = Simplification of the revised Geneva score for assessing clinical probability of pulmonary embolism | journal = Archives of Internal Medicine | volume = 168 | issue = 19 | pages = 2131–2136 | date = October 2008 | pmid = 18955643 | doi = 10.1001/archinte.168.19.2131 | doi-access = free }} A version of the revised score was modified to be applicable to pregnant patients.{{cite journal | vauthors = Robert-Ebadi H, Elias A, Sanchez O, Le Moigne E, Schmidt J, Le Gall C, Aujesky D, Roy PM, Moumneh T, Chauleur C, Rouyer F, Le Gal G, Righini M | display-authors = 6 | title = Assessing the clinical probability of pulmonary embolism during pregnancy: The Pregnancy-Adapted Geneva (PAG) score | journal = Journal of Thrombosis and Haemostasis | volume = 19 | issue = 12 | pages = 3044–3050 | date = December 2021 | pmid = 34496121 | pmc = 9293232 | doi = 10.1111/jth.15521 }}
Original Geneva Score
The original Geneva score was developed in 2001 in Geneva, Switzerland.
It's calculated using 7 risk factors and clinical variables:
class=wikitable border=1
!Variable !Score |
colspan=2|Age |
---|
60–79 years
|style="text-align:center"|1 |
80+ years
|style="text-align:center"|2 |
colspan=2|Previous venous thromboembolism |
Previous DVT or PE
|style="text-align:center"|2 |
colspan=2|Previous surgery |
Recent surgery within 4 weeks
|style="text-align:center"|3 |
colspan=2|Heart rate |
Heart rate >100 beats per minute
|style="text-align:center"|1 |
colspan=2|PaCO2 (partial pressure of CO2 in arterial blood) |
<35mmHg
|style="text-align:center"|2 |
35-39mmHg
|style="text-align:center"|1 |
colspan=2|PaO2 (partial pressure of O2 in arterial blood) |
<49mmHg
|style="text-align:center"|4 |
49-59mmHg
|style="text-align:center"|3 |
60-71mmHg
|style="text-align:center"|2 |
72-82mmHg
|style="text-align:center"|1 |
colspan=2|Chest X-ray findings |
Band atelectasis
|style="text-align:center"|1 |
Elevation of hemidiaphragm
|style="text-align:center"|1 |
The score obtained relates to the probability of the patient having had a pulmonary embolism (the lower the score, the lower the probability):
- <5 points indicates a low probability of PE (10%)
- 5 - 8 points indicates a moderate probability of PE ( 38%)
- >8 points indicates a high probability of PE. (81%)
Revised Geneva Score
In 2006 the revised Geneva score was introduced.{{cite journal | vauthors = Le Gal G, Righini M, Roy PM, Sanchez O, Aujesky D, Bounameaux H, Perrier A | title = Prediction of pulmonary embolism in the emergency department: the revised Geneva score | journal = Annals of Internal Medicine | volume = 144 | issue = 3 | pages = 165–171 | date = February 2006 | pmid = 16461960 | doi = 10.7326/0003-4819-144-3-200602070-00004 | s2cid = 28777714 }} This simplifies the scoring process, and has also been shown to be as effective as the Wells score.{{cite journal | vauthors = Righini M, Le Gal G, Aujesky D, Roy PM, Sanchez O, Verschuren F, Rutschmann O, Nonent M, Cornuz J, Thys F, Le Manach CP, Revel MP, Poletti PA, Meyer G, Mottier D, Perneger T, Bounameaux H, Perrier A | display-authors = 6 | title = Diagnosis of pulmonary embolism by multidetector CT alone or combined with venous ultrasonography of the leg: a randomised non-inferiority trial | journal = Lancet | volume = 371 | issue = 9621 | pages = 1343–1352 | date = April 2008 | pmid = 18424324 | doi = 10.1016/S0140-6736(08)60594-2 | s2cid = 16539686 }}
The revised score uses 8 parameters, but does not include figures which require an arterial blood gas sample to be performed:
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!Variable !Score |
Age 65 years or over
|style="text-align:center"|1 |
Previous DVT or PE
|style="text-align:center"|3 |
Surgery or fracture within 1 month
|style="text-align:center"|2 |
Active malignant condition
|style="text-align:center"|2 |
Unilateral lower limb pain
|style="text-align:center"|3 |
Hemoptysis
|style="text-align:center"|2 |
Heart rate 75 to 94 beats per minute
|style="text-align:center"|3 |
Heart rate 95 or more beats per minute
|style="text-align:center"|5 |
Pain on deep palpation of lower limb and unilateral edema
|style="text-align:center"|4 |
The score obtained relates to probability of PE:
- 0 - 3 points indicates low probability (8%)
- 4 - 10 points indicates intermediate probability (29%)
- 11 points or more indicates high probability (74%)
The probabilities derived from the scoring systems can be used to determine the need for, and nature of, further investigations such as D-dimer, ventilation/perfusion scanning and CT pulmonary angiography to confirm or refute the diagnosis of PE.
Simplified Geneva Score
A newer revision referred to as the simplified revised Geneva score has been prospectively studied and reported in the Archives of Internal Medicine on October 27 of 2008. The simplified scoring system replaced the weighted scores for each parameter with a 1-point score for each parameter present to reduce the likelihood of error when the score is used in a clinical setting. The report noted that the simplified Geneva score does not lead to a decrease in diagnostic utility in evaluating patients for a PE when compared to previous Geneva scores.
The simplified Geneva score:
class=wikitable border=1
!Variable !Score |
Age >65
|style="text-align:center"|1 |
Previous DVT or PE
|style="text-align:center"|1 |
Surgery or fracture within 1 month
|style="text-align:center"|1 |
Active malignancy
|style="text-align:center"|1 |
Unilateral lower limb pain
|style="text-align:center"|1 |
Hemoptysis
|style="text-align:center"|1 |
Pain on deep vein palpation of lower limb and unilateral edema
|style="text-align:center"|1 |
Heart rate 75 to 94 bpm
|style="text-align:center"|1 |
Heart rate greater than 94 bpm
|style="text-align:center"| |
Patients with a score of 2 or less are considered unlikely to have a current PE. Authors suggest that the likelihood of patients having a PE with a simplified Geneva score less than 2 and a normal D-Dimer is 3 percent.{{cite web |url=http://firstwatch.jwatch.org/cgi/content/full/2008/1029/1 |title=Geneva Scoring for Pulmonary Embolism Simplified Further. Physician's First Watch October 29, 2008 |access-date=January 25, 2009 }} Login to free text may be required.
Pregnancy Adapted Geneva (PAG)
In 2021, the items of the Revised Geneva Score were re-evaluated on pregnant women. Some items were removed, and the threshold values for the remaining items were modified to better discriminate patients even with the altered physiologic baseline of pregnancy (e.g. higher cut-off value for heart rate, lower cut-off value for age). The ROC for the resulting score had an AUC of 0.795 (CI 0.690–0.899) according to the authors, which is similar to (and even better than) the Revised Geneva Score. It's important to note, that this AUC was measured in the pregnant population, and the score was not generalized to include pregnant patients, but modified for the characteristics of pregnant patients. It's not tested on non-pregnant patients.
Patients are categorized in 3 pre-test probability groups:
- 0-1 points: low risk ( <10% risk of PE)
- 2-6 points: intermediate risk ( 10-50% risk of PE)
- >6 points: high risk ( >50% risk of PE
References
{{reflist}}
External links
[https://www.evidencio.com/models/show/341 Online Calculator of the Revised Geneva Score]
Category:Diagnostic emergency medicine