George Chaldakov

• Concept of the secretory function/phenotype of the vascular smooth muscle cell, as related to atherogenesis.

{{cite book

|vauthors=Chaldakov GN, Nikolov SD | chapter = Ultrastructure of the arterial smooth muscle cell

| title = Smooth Muscle of the Artery

|editor1=Stewart Wolf |editor2=Nicholas Theodore Werthessen | publisher = Plenum Press

| location = New York City

| pages = 14–20

| year = 1975

| isbn = 978-0-306-39057-9

| oclc = 1288413

}}

{{cite journal

|vauthors=Chaldakov GN, Nikolov SD, Vankov VN | title = Fine morphological aspects of the secretory process of arterial smooth muscle cells. II. Role of microtubules

| journal = Acta Morphologica Academiae Scientiarum Hungaricae

| volume = 25

| pages = 167–174

| year = 1977

| pmid = 615419

| issue = 2–3

}}

{{cite journal

|vauthors=Chaldakov GN, Vankov VN | title = Morphological aspects of secretion in the arterial smooth muscle cell, with special reference to the Golgi complex and microtubular cytoskeleton

| journal = Atherosclerosis

| volume = 61

| pages = 175–192

| year = 1986

| doi = 10.1016/0021-9150(86)90137-1

| pmid = 3533092

| issue = 3

}}

• Tubulin/microtubule-targeted pharmacology for atherosclerosis.

{{cite journal

| author = Chaldakov GN

| title = Antitubulins - a new therapeutic approach for atherosclerosis?

| journal = Atherosclerosis

| volume = 44

| pages = 385–390

| year = 1982

| doi = 10.1016/0021-9150(82)90013-2

| issue = 3

}}

{{cite book

|vauthors=Chaldakov GN, Vankov VN | chapter = Antifibrotic approach in the therapy of arterial occlusive diseases: new considerations

| title = Konservative Therapie arterieller Durchblutungsstörungen

|trans-title=Conservative Therapy of Arterial Occlusive Disease

| editor = Gustav Trübestein

| publisher = Thieme Medical Publishers

| location = Stuttgart

| pages = 224–226

| year = 1986

| isbn = 978-3-13-688101-9

| oclc = 246829648

}}

{{cite journal

| author = Chaldakov GN

| title = Anti-inflammatory drugs and ischemic heart disease: new considerations (a cell biologist's proposal to cardiologists)

| journal = Journal of the American College of Cardiology

| volume = 17

| pages = 1445–1446

| year = 1991

| pmid = 2016465

| issue = 6

| doi = 10.1016/S0735-1097(10)80161-5

| doi-access = free

}}

• Concept of the neurotrophins NGF and BDNF as metabotrophic factors (metabotrophins) in cardiometabolic biology/diseases.

{{cite journal

|vauthors=Chaldakov GN, Fiore M, Hristova M, Aloe L | title = Metabotrophic potential of neurotrophins: implication in obesity and related diseases?

| journal = Medical Science Monitor

| volume = 9

| issue = 10

| pages = HY19–21

| year = 2003

| pmid = 14523335

| url = http://www.MedSciMonit.com/pub/vol_9/no_10/3664.pdf

}}

{{cite journal

|vauthors=Manni L, Nikolova V, Vyagova D, Chaldakov GN, Aloe L | title = Reduced plasma levels of NGF and BDNF in patients with acute coronary syndromes

| journal = International Journal of Cardiology

| volume = 102

| pages = 169–171

| year = 2005

| doi = 10.1016/j.ijcard.2004.10.041

| pmid = 15939120

| issue = 1

}}

• Conceptualize the protein secretory products of adipose tissue cells as adipokines, also focusing on perivascular adipose tissue.

{{cite journal

|author1=Chaldakov GN |author2=Fiore M |author3=Ghenev PI |author4=Stankulov IS Aloe L | title = Atherosclerotic lesions: possible interactive involvement of intima, adventitia and associated adipose tissue

| journal = The International Medical Journal

| volume = 7

| pages = 43–49

| year = 2000

}}

{{cite journal

|vauthors=Chaldakov GN, Stankulov IS, Aloe L | title = Subepicardial adipose tissue in human coronary atherosclerosis: another neglected phenomenon

| journal = Atherosclerosis

| volume = 154

| pages = 237–238

| year = 2001

| doi = 10.1016/S0021-9150(00)00676-6

| pmid = 11190652

| issue = 1

}}

{{cite journal

|vauthors=Chaldakov GN, Stankulov IS, Fiore M, Ghenev PI, Aloe L | title = Nerve growth factor levels and mast cell distribution in human coronary atherosclerosis

| journal = Atherosclerosis

| volume = 159

| pages = 57–66

| year = 2001

| doi = 10.1016/S0021-9150(01)00488-9

| pmid = 11689207

| issue = 1

}}

• Conceptualize studying adipose tissue-directed pharmacology as adipopharmacology.

{{cite journal

|vauthors=Chaldakov GN, Stankulov IS, Hristova MG, Ghenev PI | title = Adipobiology of disease: adipokines and adipokine-targeted pharmacology

| journal = Current Pharmaceutical Design

| volume = 9

| pages = 1023–1031

| year = 2003

| doi = 10.2174/1381612033455152

| pmid = 12678860

| issue = 12

}}

{{cite journal

|vauthors=Chaldakov GN, Fiore M, Hristova M, Aloe L | title = Cell biology and pharmacology of adipose tissue secretion

| journal = FABAD Journal of Pharmaceutical Sciences

| volume = 25

| pages = 181–191

| year = 2000

}}

{{cite journal

|vauthors=Chaldakov GN, Fiore M, Tonchev AB, Aloe L | title = Adipopharmacology, a novel drug discovery approach: a metabotrophic perspective

| journal = Letters in Drug Design & Discovery

| volume = 3

| pages = 503–505

| year = 2006

| doi = 10.2174/157018006778194835

| issue = 7

}}

• In 2006 introduced the term Homo obesus and is actively involved in popularizing the need of healthy lifestyle and dietary restriction: millions of people suffer and die from starvation in ill-developed and poor countries while in Western world and Europe people get overweight and die as a result of strokes or heart infarctions.

{{cite journal

|vauthors=Chaldakov GN, Fiore M, Tonchev AB, Dimitrov D, Pancheva R, Rancic G, Aloe L | title = Homo obesus: a metabotrophin-deficient species. Pharmacology and nutrition insight

| journal = Current Pharmaceutical Design

| volume = 13

| pages = 2176–2179

| year = 2007

| doi = 10.2174/138161207781039616

| pmid = 17627549

| issue = 21

}}

{{cite web

|url= http://www.thedoctorcooks.com/2008/03/homo-obesus.html

|title= HOMO OBESUS? (cream of broccoli and cashew soup)

|author= Bethany Klug

|year= 2008

|work=

|publisher= The Doctor Cooks

|accessdate= 25 February 2012

|archive-url= https://web.archive.org/web/20110806174158/http://www.thedoctorcooks.com/2008/03/homo-obesus.html

|archive-date= 6 August 2011

|url-status= dead

}}

{{Reflist|2}}

• [http://www.bgscb.org/ Bulgarian Society for Cell Biology]
• [http://press.mu-varna.bg/ojs/index.php/bmr Biomedical Reviews], {{ISSN|1314-1929}}
• [http://press.mu-varna.bg/ojs/index.php/adipo Adipobiology], {{ISSN|1313-3705}}
• [http://www.emedicine.com/med/topic182.htm eMedicine - Atherosclerosis: Article by F Brian Boudi, MD]
• [http://www.eas-society.org/ The European Atherosclerosis Society]
• [http://www.mu-varna.bg Medical University of Varna Website]

{{Authority control}}

{{DEFAULTSORT:Chaldakov, George}}

Category:Bulgarian medical researchers

Category:Bulgarian biologists

Category:Living people

Category:1940 births