Geranylfarnesyl diphosphate synthase

{{short description|Enzyme}}

{{Infobox enzyme

| Name = Geranylfarnesyl diphosphate synthase

| EC_number = 2.5.1.81

| CAS_number =

| GO_code =

| image =

| width =

| caption =

}}

Geranylfarnesyl diphosphate synthase ({{EC number|2.5.1.81}}, FGPP synthase, (all-E) geranylfarnesyl diphosphate synthase, GFPS, Fgs) is an enzyme with systematic name geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 1 isopentenyl unit).{{cite journal | vauthors = Ogawa T, Yoshimura T, Hemmi H | title = Geranylfarnesyl diphosphate synthase from Methanosarcina mazei: Different role, different evolution | journal = Biochemical and Biophysical Research Communications | volume = 393 | issue = 1 | pages = 16–20 | date = February 2010 | pmid = 20097171 | doi = 10.1016/j.bbrc.2010.01.063 }}{{cite journal | vauthors = Tachibana A, Yano Y, Otani S, Nomura N, Sako Y, Taniguchi M | title = Novel prenyltransferase gene encoding farnesylgeranyl diphosphate synthase from a hyperthermophilic archaeon, Aeropyrum pernix. Molecularevolution with alteration in product specificity | journal = European Journal of Biochemistry | volume = 267 | issue = 2 | pages = 321–8 | date = January 2000 | pmid = 10632701 | doi = 10.1046/j.1432-1327.2000.00967.x | doi-access = free }}{{cite journal | vauthors = Tachibana A | title = A novel prenyltransferase, farnesylgeranyl diphosphate synthase, from the haloalkaliphilic archaeon, Natronobacterium pharaonis | journal = FEBS Letters | volume = 341 | issue = 2-3 | pages = 291–4 | date = March 1994 | pmid = 8137956 | doi = 10.1016/0014-5793(94)80475-3 | doi-access = }}{{cite journal | vauthors = Lee PC, Mijts BN, Petri R, Watts KT, Schmidt-Dannert C | title = Alteration of product specificity of Aeropyrum pernix farnesylgeranyl diphosphate synthase (Fgs) by directed evolution | journal = Protein Engineering, Design & Selection | volume = 17 | issue = 11 | pages = 771–7 | date = November 2004 | pmid = 15548566 | doi = 10.1093/protein/gzh089 | doi-access = free }} This enzyme catalyses the following chemical reaction

: geranylgeranyl diphosphate + isopentenyl diphosphate $\backslash rightleftharpoons$ (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate

The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine.