Gerard Kleywegt
{{Short description|Dutch X-ray crystallographer}}
{{Infobox scientist
| name = Gerard Kleywegt
| birth_name = Gerrit Jacob Kleijwegt
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| birth_date = {{Birth year and age|1962}}
| birth_place = Rozenburg, Nederland
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| nationality = Dutch
| fields = {{Plainlist|* Structural biology}}
| workplaces = European Bioinformatics Institute
University of Upsala
| alma_mater = University of Utrecht
| thesis_title = Computer-assisted assignment of 2D and 3D NMR spectra of proteins (Computer-ondersteunde toekenning van 2D en 3D NMR spectra van eiwitten)
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| thesis_year = 1991
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| website = http://www.ebi.ac.uk/about/people/gerard-kleywegt
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}}
Gerard Jacob Kleywegt (born 5 June 1962, in Rozenburg) is a Dutch X-ray crystallographer and the former team leader of the Protein Data Bank in Europe at the EBI;{{cite web|url=http://www.ebi.ac.uk/pdbe/about/news/looking-back-2016 | title=Looking back on 2016}}{{cite web|url=http://www.ebi.ac.uk/about/people/gerard-kleywegt|archiveurl=https://web.archive.org/web/20141020134756/http://www.ebi.ac.uk/about/people/gerard-kleywegt|archivedate=2014-10-20 | title=Gerard Kleywegt research group page at the EBI}}Garwoord, Jeremy (May 2009) [http://www.labtimes.org/labtimes/issues/lt2009/lt05/lt_2009_05_18_23.pdf "A Guardian of Structural Integrity"]. Lab Times. pp. 19-23{{Cite journal | last1 = Berman | first1 = H. M. | last2 = Kleywegt | first2 = G. J. | last3 = Nakamura | first3 = H. | last4 = Markley | first4 = J. L. | last5 = Burley | first5 = S. K. | title = Safeguarding the integrity of protein archive | doi = 10.1038/463425c | journal = Nature | volume = 463 | issue = 7280 | pages = 425 | year = 2010 | pmid = 20110969| pmc = 4456675}} a member of the Worldwide Protein Data Bank.{{Cite journal
| pmid = 25348407
| year = 2015
| last1 = Lewis
| first1 = T. E.
| title = Genome3D: Exploiting structure to help users understand their sequences
| journal = Nucleic Acids Research
| volume = 43
| issue = Database issue
| pages = D382-6
| last2 = Sillitoe
| first2 = I
| last3 = Andreeva
| first3 = A
| last4 = Blundell
| first4 = T. L.
| last5 = Buchan
| first5 = D. W.
| last6 = Chothia
| first6 = C
| authorlink6 = Cyrus Chothia
| last7 = Cozzetto
| first7 = D
| last8 = Dana
| first8 = J. M.
| last9 = Filippis
| first9 = I
| last10 = Gough
| first10 = J
| authorlink10 = Julian Gough (scientist)
| last11 = Jones
| first11 = D. T.
| last12 = Kelley
| first12 = L. A.
| last13 = Kleywegt
| first13 = G. J.
| authorlink13 = Gerard Kleywegt
| last14 = Minneci
| first14 = F
| last15 = Mistry
| first15 = J
| last16 = Murzin
| first16 = A. G.
| last17 = Ochoa-Montaño
| first17 = B
| last18 = Oates
| first18 = M. E.
| last19 = Punta
| first19 = M
| last20 = Rackham
| first20 = O. J.
| last21 = Stahlhacke
| first21 = J
| last22 = Sternberg
| first22 = M. J.
| authorlink22 = Michael Sternberg
| last23 = Velankar
| first23 = S
| last24 = Orengo
| first24 = C
| doi = 10.1093/nar/gku973
| pmc=4384030
| pmid = 23203986
| pmc = 3531217
| year = 2013
| last1 = Lewis
| first1 = T. E.
| title = Genome3D: A UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains
| journal = Nucleic Acids Research
| volume = 41
| issue = Database issue
| pages = D499-507
| last2 = Sillitoe
| first2 = I
| last3 = Andreeva
| first3 = A
| last4 = Blundell
| first4 = T. L.
| last5 = Buchan
| first5 = D. W.
| last6 = Chothia
| first6 = C
| authorlink6 = Cyrus Chothia
| last7 = Cuff
| first7 = A
| last8 = Dana
| first8 = J. M.
| last9 = Filippis
| first9 = I
| last10 = Gough
| first10 = J
| authorlink10 = Julian Gough (scientist)
| last11 = Hunter
| first11 = S
| last12 = Jones
| first12 = D. T.
| last13 = Kelley
| first13 = L. A.
| last14 = Kleywegt
| first14 = G. J.
| authorlink14 = Gerard Kleywegt
| last15 = Minneci
| first15 = F
| last16 = Mitchell
| first16 = A
| last17 = Murzin
| first17 = A. G.
| last18 = Ochoa-Montaño
| first18 = B
| last19 = Rackham
| first19 = O. J.
| last20 = Smith
| first20 = J
| last21 = Sternberg
| first21 = M. J.
| authorlink21 = Michael Sternberg
| last22 = Velankar
| first22 = S
| last23 = Yeats
| first23 = C
| last24 = Orengo
| first24 = C
| doi = 10.1093/nar/gks1266
}}
Education
Kleywegt obtained his PhD from the University of Utrecht in 1991.
Career
After his PhD, Kleywegt did postdoctoral research with Alwyn Jones at Uppsala University.{{Cite journal | last1 = Jones | first1 = T. A. | last2 = Kleywegt | first2 = G. J. | title = Experimental Data for Structure Papers | journal = Science | volume = 317 | issue = 5835 | pages = 194–195 | year = 2007 | doi = 10.1126/science.317.5835.194c| pmid = 17626864 }}{{Cite journal
| pmid = 8994966
| year = 1996
| last1 = Kleywegt
| first1 = G. J.
| title = Phi/psi-chology: Ramachandran revisited
| journal = Structure
| volume = 4
| issue = 12
| pages = 1395–400
| last2 = Jones
| first2 = T. A.
| doi=10.1016/s0969-2126(96)00147-5
| doi-access = free
}} before moving to the EBI.
Research
Kleywegt's research focuses on protein crystallography{{Cite journal
| pmid = 22000512
| pmc = 3195755
| year = 2011
| last1 = Read
| first1 = R. J.
| title = A new generation of crystallographic validation tools for the protein data bank
| journal = Structure
| volume = 19
| issue = 10
| pages = 1395–412
| last2 = Adams
| first2 = P. D.
| last3 = Arendall Wb
| first3 = 3rd
| last4 = Brunger
| first4 = A. T.
| last5 = Emsley
| first5 = P
| last6 = Joosten
| first6 = R. P.
| last7 = Kleywegt
| first7 = G. J.
| last8 = Krissinel
| first8 = E. B.
| last9 = Lütteke
| first9 = T
| last10 = Otwinowski
| first10 = Z
| last11 = Perrakis
| first11 = A
| last12 = Richardson
| first12 = J. S.
| last13 = Sheffler
| first13 = W. H.
| last14 = Smith
| first14 = J. L.
| last15 = Tickle
| first15 = I. J.
| last16 = Vriend
| first16 = G
| last17 = Zwart
| first17 = P. H.
| doi = 10.1016/j.str.2011.08.006
| pmid = 19171969
| pmc = 2631636
| year = 2009
| last1 = Read
| first1 = R. J. | authorlink1 = Randy Read
| title = Case-controlled structure validation
| journal = Acta Crystallographica Section D
| volume = 65
| issue = Pt 2
| pages = 140–7
| last2 = Kleywegt
| first2 = G. J. | authorlink2 = Gerard Kleywegt
| doi = 10.1107/S0907444908041085
| pmid = 9438862
| year = 1997
| last1 = Kleywegt
| first1 = G. J. | authorlink1 = Gerard Kleywegt
| title = Not your average density
| journal = Structure
| volume = 5
| issue = 12
| pages = 1557–69
| last2 = Read
| first2 = R. J.| authorlink2 = Randy Read
| doi=10.1016/s0969-2126(97)00305-5
| doi-access = free
}} and the Protein Data Bank.{{Cite journal
| pmid = 24010715
| pmc = 3884077
| year = 2013
| last1 = Montelione
| first1 = G. T.
| title = Recommendations of the wwPDB NMR Validation Task Force
| journal = Structure
| volume = 21
| issue = 9
| pages = 1563–70
| last2 = Nilges
| first2 = M
| last3 = Bax
| first3 = A
| last4 = Güntert
| first4 = P
| last5 = Herrmann
| first5 = T
| last6 = Richardson
| first6 = J. S.
| last7 = Schwieters
| first7 = C. D.
| last8 = Vranken
| first8 = W. F.
| last9 = Vuister
| first9 = G. W.
| last10 = Wishart
| first10 = D. S.
| last11 = Berman
| first11 = H. M.
| last12 = Kleywegt
| first12 = G. J.
| last13 = Markley
| first13 = J. L.
| doi = 10.1016/j.str.2013.07.021
| pmid = 24010707
| year = 2013
| last1 = Berman
| first1 = H. M.
| title = How community has shaped the Protein Data Bank
| journal = Structure
| volume = 21
| issue = 9
| pages = 1485–91
| last2 = Kleywegt
| first2 = G. J.
| last3 = Nakamura
| first3 = H
| last4 = Markley
| first4 = J. L.
| doi = 10.1016/j.str.2013.07.010
| pmc=4435976
| pmid = 23023942
| pmc = 3684242
| year = 2013
| last1 = Berman
| first1 = H. M.
| title = The future of the protein data bank
| journal = Biopolymers
| volume = 99
| issue = 3
| pages = 218–22
| last2 = Kleywegt
| first2 = G. J.
| last3 = Nakamura
| first3 = H
| last4 = Markley
| first4 = J. L.
| doi = 10.1002/bip.22132
| pmid = 22404998
| pmc = 3501388
| year = 2012
| last1 = Berman
| first1 = H. M. | authorlink1 = Helen M. Berman
| title = The Protein Data Bank at 40: Reflecting on the past to prepare for the future
| journal = Structure
| volume = 20
| issue = 3
| pages = 391–6
| last2 = Kleywegt
| first2 = G. J. | authorlink2 = Gerard Kleywegt
| last3 = Nakamura
| first3 = H
| last4 = Markley
| first4 = J. L.
| doi = 10.1016/j.str.2012.01.010
| last1 = Berman | first1 = H. M.
| last2 = Kleywegt | first2 = G. J.
| last3 = Nakamura | first3 = H.
| last4 = Markley | first4 = J. L.
| last5 = Burley | first5 = S. K.
| title = Safeguarding the integrity of protein archive
| doi = 10.1038/463425c
| journal = Nature
| volume = 463
| issue = 7280
| pages = 425
| year = 2010
| pmid = 20110969
| pmc = 4456675
| pmid = 25062767
| pmc = 4196035
| year = 2014
| last1 = Berman
| first1 = H. M.
| title = The Protein Data Bank archive as an open data resource
| journal = Journal of Computer-Aided Molecular Design
| volume = 28
| issue = 10
| pages = 1009–14
| last2 = Kleywegt
| first2 = G. J.
| last3 = Nakamura
| first3 = H
| last4 = Markley
| first4 = J. L.
| doi = 10.1007/s10822-014-9770-y
| pmid = 25286863
| year = 2014
| last1 = Berman
| first1 = H. M.
| title = Response to on prompt update of literature references in the Protein Data Bank
| journal = Acta Crystallographica Section D
| volume = 70
| issue = Pt 10
| pages = 2780
| last2 = Burley
| first2 = S. K.
| last3 = Kleywegt
| first3 = G. J.
| last4 = Nakamura
| first4 = H
| last5 = Markley
| first5 = J. L.
| doi = 10.1107/S1399004714020513
| pmc=4984264
}}
References
{{reflist|35em}}
{{Authority control}}
{{DEFAULTSORT:Kleywegt, Gerard}}
Category:Leiden University alumni