Given Imaging
{{Infobox company
| name = Given Imaging Ltd.
| logo =
| type = Private
| traded_as = {{ubl|{{NASDAQ was|GIVN}}|{{TASE was|GIVN}}}}
| foundation = {{start date and age|1998}}
| location = Yokneam Illit, Israel
| industry = Medical technology
| products = Capsule endoscopy
| revenue = {{profit}} US$ 177.95 million (2011)
| operating_income = {{profit}} US$ 12.98 million (2011)
| net_income = {{profit}} US$ 11.97 million (2011)
| num_employees = 800
| key_people = Homi Shamir (CEO)
| owner = Medtronic
| homepage = {{url|http://givenimaging.com}}
}}
Given Imaging Ltd. (Hebrew: גיוון אימג'ינג) is an Israeli medical technology company that manufactures and markets diagnostic products for the visualization and detection of disorders of the gastrointestinal tract. Until March 2014, it was dual-listed on both the NASDAQ and the Tel Aviv Stock Exchange, where it was a component of the TA-100 Index and the TA BlueTech Index. In March 2014 it was acquired by Covidien and became a private company. In 2015 Covidien was purchased by Medtronic.
Given Imaging pioneered the capsule endoscopy technology and has also developed capsule-based pH monitoring.{{Cite web |url=http://www.investinisrael.gov.il/NR/exeres/01104877-8720-4F39-8441-BD24EC58D8B9.htm |title=Invest in Israel: Given Imaging |access-date=2010-10-14 |archive-url=https://web.archive.org/web/20110721142613/http://www.investinisrael.gov.il/NR/exeres/01104877-8720-4F39-8441-BD24EC58D8B9.htm |archive-date=2011-07-21 |url-status=dead }} Through Sierra Scientific Instruments, a subsidiary, Given Imaging also provides an array of diagnostic modalities including high-resolution manometry and ambulatory reflux monitoring. Given Imaging's technology is currently marketed in over 60 countries.
History
Given Imaging was founded in 1998 by Gavriel Meron and Rafael Development Corporation (RDC) Ltd. based on the purchase of an early patent from Rafael Advanced Defense Systems Ltd. Initial funding for the company was provided by Elron Electronic Industries, Israel's leading technology holding company, in cooperation with Rafael. Today, Elron still holds 28% Given Imaging's shares.[http://www.highbeam.com/doc/1G1-78880412.html Elron Announces That Given Imaging, Held Directly and Indirectly 15% by Elron, Announced Initial Public Offering. Business Wire, October 4, 2001]{{dead link|date=February 2019|bot=medic}}{{cbignore|bot=medic}} The idea for the solution was developed by Dr. Iddan, while working in the missile division of Rafael, where he envisioned that missile technology could be miniaturized to create a medical product.{{Cite web |url=http://www.rdc.co.il/default.asp?catid=%7BCAB37C31-E9B2-4549-ABC6-64327B120209%7D |title=RDC – Rafael Development Corporation Ltd - Given Imaging Copnay History |access-date=2019-12-29 |archive-url=https://web.archive.org/web/20140802064832/http://www.rdc.co.il/default.asp?catid=%7BCAB37C31-E9B2-4549-ABC6-64327B120209%7D |archive-date=2014-08-02 |url-status=dead }}
The company's first capsule endoscopy products was named M2A capsule and received it CE marking in May 2001 and in August 2001 was cleared
by the US Food and Drug Administration (FDA) for visualization of abnormalities of the small intestine[http://www.aetna.com/cpb/medical/data/500_599/0588.html Athena: Clinical Policy Bulletin: Capsule Endoscopy] The capsule uses a radio developed for Given by Zarlink Semiconductor's medical team in San Diego and Jarfalla, Sweden.
In October 2001, Given Imaging had an Initial public offering on NASDAQ under ticker GIVN.)[http://www.marketwatch.com/story/given-imaging-first-ipo-since-august Given Imaging: First IPO since August IPO Report - MarketWatch - 4 Oct 2001 ] In September 2004, M2A capsule re-branded PillCam SB(R).
In March 2004, Given Imaging became a member of the Tel Aviv Stock Exchange[http://maya.tase.co.il/bursa/report.asp?report_cd=94385 Given Imaging Registration Document March 22, 2004]
In November 2004, US FDA clears PillCam(R) ESO for the esophagus
In May 2006, US FDA clears Agile Patency System{{Cite web |url=http://www.medicalnewstoday.com/articles/43358.php |title=Given Imaging's Agile(TM) Patency System Receives US Marketing Clearance, Medical News Today, 17 May 2006 |access-date=16 October 2010 |archive-date=24 September 2010 |archive-url=https://web.archive.org/web/20100924040720/http://www.medicalnewstoday.com/articles/43358.php |url-status=dead }}
In October 2006, PillCam COLON was cleared for marketing in the European Union (CE Mark){{Cite web |url=http://www.medicalnewstoday.com/articles/103575.php |title=Pillcam(R) COLON May Be A Cost-Effective Strategy For Preventing Colo-Rectal Cancer, Study, Medical News Today 11 Apr 2008 |access-date=16 October 2010 |archive-date=4 January 2009 |archive-url=https://web.archive.org/web/20090104150653/http://www.medicalnewstoday.com/articles/103575.php |url-status=dead }}
In December 2008, Given Imaging acquired Bravo pH Monitoring System(R)
In May 2009, 1 millionth PillCam capsule was sold[http://www.marketwire.com/press-release/Given-Imaging-Announces-One-Millionth-PillCam-Video-Capsule-NASDAQ-GIVN-992283.htm Given Imaging Announces One Millionth PillCam Video Capsule, Marketwire May 20, 2009]
In September 2009, PillCam COLON 2 receives CE Mark[http://www.news-medical.net/news/20090914/Given-Imagingc-PillCam-COLON-2-video-capsule-and-system-receives-the-CE-mark-for-sale-in-Europe.aspx Given Imaging'c PillCam COLON 2 video capsule and system receives the CE mark for sale in Europe, The Medical News, 14. September]
In July 2012, Given Imaging's capsule endoscopy featured in a live broadcast on the BBC, when the reporter Michael Mosley spent the day as an exhibit at the Science Museum in London, after swallowing a PillCam which transmitted live pictures to a public screen.[https://www.bbc.co.uk/news/health-18779997 The second brain in our stomachs], 12 July 2012, Michael Mosley, BBC
In February 2014, 100% of Given Imaging's shares were purchased by Covidien, making it a Private Company fully owned by Covidien. As a result, its shares are no longer traded neither in NASDAQ nor in TASE[http://maya.tase.co.il/bursa/report.asp?report_cd=881071&CompCd=2200 Announcement Regarding Completion of Merging with Covidien]
Products
= PillCam SB =
PillCam SB is a tool for visualization of the entire small bowel and detection of small bowel abnormalities. No sedation is needed, however bowel prep is needed. A liquid bowel prep is consumed before the procedure emptying the bowel completely, this allows clear photos to be taken.{{Cite web |url=http://www.medicalnewstoday.com/articles/31745.php |title=Given Imaging to Launch Advanced PillCam(TM) SB Video Capsule for the small bowel |access-date=2010-10-14 |archive-date=2009-02-20 |archive-url=https://web.archive.org/web/20090220051006/http://www.medicalnewstoday.com/articles/31745.php |url-status=dead }}
= PillCam ESO =
PillCam ESO provides a method for visualization of the esophagus.The accuracy of PillCam ESO capsule endoscopy versus conventional upper endoscopy for the diagnosis of esophageal varices: a prospective three-center pilot study. Endoscopy. 2006;38(1):1-5. 20. Eliakim R, Fireman Z, Gralnek IM, Yassin K, Waterman M, Kopelman Y, Lachter J, Koslowsky B, Adler SN. Evaluation of the PillCam Colon capsule in the detection of colonic pathology: results of the first multicenter, prospective, comparative study. Endoscopy. 2006 Oct;38(10):963-70.
= PillCam COLON 2 =
PillCam COLON 2 is complementary to traditional colonoscopy and is used for patients who have received incomplete colonoscopy, are contraindicated for colonoscopy or are unwilling to undergo traditional colonoscopy.{{cn|date=May 2022}}
= PillCam CROHN'S =
The PillCam CROHN’S system offers direct visualization of the entire small bowel and colonic mucosa with a noninvasive procedure.
= PillCam Express =
In May 2010, Given Imaging released a new manually guided GI scope based on PillCam swallowable devices. In cases where patient anatomy does not allow for natural passage of large tablets the size of traditional PillCams, the PillCam Express can be delivered through the stomach and into the small intestine with help of an endoscope and a proprietary balloon deployment mechanism.[https://archive.today/20120712074447/http://medgadget.com/archives/2010/05/pillcam_express_when_traditional_pillcam_is_too_hard_to_swallow.html MedGadget: PillCam Express]
= Bravo pH Monitoring System =
The Bravo pH Monitoring System is a catheter-free ambulatory pH test.{{Cite web |url=http://www.woosterhospital.org/pages/hospitalservices/Endoscopy.aspx |title=Endoscopy Unit - Bravo PH Monitoring System - Wooster Community Hospital |access-date=2010-10-16 |archive-url=https://web.archive.org/web/20101025160755/http://www.woosterhospital.org/pages/hospitalservices/Endoscopy.aspx |archive-date=2010-10-25 |url-status=dead }} Ambulatory pH testing is considered the gold standard for pH measurement and monitoring of gastric reflux, helping clinicians manage gastroesophageal reflux disease (GERD). Featuring data collection for up to 96 hours, Bravo allows patients to maintain their regular diets and activities, accurately reflecting normal physiologic conditions.{{cn|date=May 2022}}
= Sierra Scientific Instruments =
In April 2010, Given Imaging acquired Sierra Scientific Instruments.[http://www.mddionline.com/article/given-imaging-acquires-sierra-scientific-instruments Given Imaging Acquires Sierra Scientific Instruments | MDDI Magazine]
Headquarters and plants
The company's corporate headquarters, research and development laboratories, and manufacturing facilities are located in Yokneam, Israel.[http://medtronicsolutions.medtronic.com/given-imaging Updating website] [https://www.medtronic.com/us-en/healthcare-professionals/medical-specialties/gastroenterology.html Present website] (July 2023) It maintains offices in Duluth, Georgia and Heerlen, Netherlands. Additional sales and marketing offices are located in France, Japan, Australia, and Singapore. The company also has a plant in Ireland.{{cn|date=May 2022}}
Given Imaging's wholly owned subsidiary, Sierra Scientific Instruments, is located in Los Angeles, California, with manufacturing operations in Vietnam.{{cn|date=May 2022}}