Glutamine—fructose-6-phosphate transaminase (isomerizing)

{{infobox enzyme

| Name = glutamine-fructose-6-phosphate transaminase (isomerizing)

| AltNames = {{ubl|hexosephosphate aminotransferase|glucosamine-6-phosphate isomerase (glutamine-forming)|glutamine-fructose-6-phosphate transaminase (isomerizing)|D-fructose-6-phosphate amidotransferase|glucosaminephosphate isomerase|glucosamine 6-phosphate synthase|GlcN6P synthase}}

| EC_number = 2.6.1.16

| CAS_number = 9030-45-9

| GO_code = 0004360

| image = 6svm.jpg

| width = 270

| caption = Glutamine—fructose-6-phosphate transaminase 1, homodimer, Human

}}

In enzymology, a glutamine-fructose-6-phosphate transaminase (isomerizing) ({{EC number|2.6.1.16}}) is an enzyme that catalyzes the chemical reaction

:L-glutamine + D-fructose 6-phosphate $\rightleftharpoons$ L-glutamate + D-glucosamine 6-phosphate

Thus, the two substrates of this enzyme are L-glutamine and D-fructose 6-phosphate, whereas its two products are L-glutamate and D-glucosamine 6-phosphate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-glutamine:D-fructose-6-phosphate isomerase (deaminating). This enzyme participates in glutamate metabolism and aminosugars metabolism.

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1JXA}}, {{PDB link|1MOQ}}, {{PDB link|1MOR}}, {{PDB link|1MOS}}, {{PDB link|1XFF}}, {{PDB link|1XFG}}, {{PDB link|2BPL}}, {{PDB link|2J6H}}, {{PDB link|2POC}}, {{PDB link|2PUT}}, {{PDB link|2PUV}}, and {{PDB link|2PUW}}.

References

{{cite journal | vauthors = Ghosh S, Blumenthal HJ, Davidson E, Roseman S | year = 1960 | title = Glucosamine metabolism. V. Enzymatic synthesis of glucosamine 6-phosphate | journal = J. Biol. Chem. | volume = 235 | issue = 5 | pages = 1265–73 | doi = 10.1016/S0021-9258(18)69397-4 | doi-access = free | pmid=13827775}}
{{cite journal | vauthors = Gryder RM, Pogell BM | year = 1960 | title = Further studies on glucosamine 6-phosphate synthesis by rat liver enzymes | journal = J. Biol. Chem. | volume = 235 | issue = 3 | pages = 558–62 | doi = 10.1016/S0021-9258(19)67904-4 | doi-access = free | pmid = 13829889 }}
{{cite journal | vauthors = Leloir LF, Cardini CE | year = 1953 | title = The biosynthesis of glucosamine | journal = Biochim. Biophys. Acta | volume = 12 | pages = 15–22 | pmid = 13115409 | doi = 10.1016/0006-3002(53)90119-X | issue = 1–2 | hdl = 11336/140740 | hdl-access = free }}
{{cite journal | vauthors = Teplyakov A, Obmolova G, Badet-Denisot MA, Badet B | year = 1999 | title = The mechanism of sugar phosphate isomerization by glucosamine 6-phosphate synthase | journal = Protein Sci. | volume = 8 | pages = 596–602 | pmid = 10091662 | issue = 3 | pmc = 2144271 | doi = 10.1110/ps.8.3.596 }}

{{DEFAULTSORT:Glutamine-fructose-6-phosphate transaminase (isomerizing)}}

Category:EC 2.6.1

Category:Enzymes of known structure