Glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)
{{infobox enzyme
| Name = glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)
| EC_number = 1.2.1.13
| CAS_number = 37250-87-6
| GO_code = 0047100
| image =
| width =
| caption =
}}
In enzymology, a glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) ({{EC number|1.2.1.13}}) is an enzyme that catalyzes the chemical reaction
:D-glyceraldehyde 3-phosphate + phosphate + NADP+ 3-phospho-D-glyceroyl phosphate + NADPH + H+
The 3 substrates of this enzyme are D-glyceraldehyde 3-phosphate, phosphate, and NADP+, whereas its 3 products are 3-phospho-D-glyceroyl phosphate, NADPH, and H+.
Function
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in the Calvin cycle which is an autotrophic carbon fixation pathway.
Nomenclature
The systematic name of this enzyme class is D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating). Other names in common use include:
- dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating)
- GAPDH
- glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating)
- glyceraldehyde-3-phosphate dehydrogenase (NADP) (phosphorylating)
- NADP-dependent glyceraldehyde phosphate dehydrogenase
- NADP-glyceraldehyde phosphate dehydrogenase
- NADP-glyceraldehyde-3-phosphate dehydrogenase
- NADP-triose phosphate dehydrogenase
- triosephosphate dehydrogenase (NADP)
References
{{reflist|1}}
Further reading
{{refbegin}}
- {{cite journal | vauthors = Brenneman FN, Volk WA | year = 1959 | title = Glyceraldehyde phosphate dehydrogenase activity with triphosphopyridine nucleotide and with diphosphopyridine nucleotide | journal = J. Biol. Chem. | volume = 234 | issue = 9 | pages = 2443–7 | doi = 10.1016/S0021-9258(18)69832-1 | doi-access = free | pmid = 13804190 }}
- {{cite book | author = Gibbs M | year = 1955 | title = [62] TPN triosephosphate dehydrogenase from plant tissue | series = Methods Enzymol. | volume = 1 | pages = 411–415 | doi=10.1016/0076-6879(55)01067-7| isbn = 978-0-12-181801-2 }}
- {{cite journal | vauthors = Rosenberg LL, Arnon DI | year = 1955 | title = The preparation and properties of a new glyceraldehyde-3-phosphate dehydrogenase from photosynthetic tissues | journal = J. Biol. Chem. | volume = 217 | pages = 361–71 | pmid = 13271400 | issue = 1 | doi = 10.1016/S0021-9258(19)57187-3 | doi-access = free }}
{{refend}}
{{Aldehyde/Oxo oxidoreductases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}
{{DEFAULTSORT:Glyceraldehyde-3-Phosphate Dehydrogenase (Nadp+) (Phosphorylating)}}
Category:NADPH-dependent enzymes
Category:Enzymes of known structure
{{1.2-enzyme-stub}}