Glycylpeptide N-tetradecanoyltransferase 2

N-myristoyltransferase (NMT) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. Biochemical evidence indicates the presence of several distinct NMTs, varying in apparent molecular weight and /or subcellular distribution. The 496-amino acid of human NMT2 protein shares 77% and 96% sequence identity with human NMT1 and mouse Nmt2 comprise two distinct families of N-myristoyltransferases.{{cite journal | vauthors = Thinon E, Serwa RA, Broncel M, Brannigan JA, Brassat U, Wright MH, Heal WP, Wilkinson AJ, Mann DJ, Tate EW | title = Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. | journal = Nat Commun | volume = 5 | pages = 4919 | year = 2014 | pmid = 25255805 | doi = 10.1038/ncomms5919 | pmc=4200515| bibcode = 2014NatCo...5.4919T }}

NMT2 has been shown to interact with:

• caspase 3{{cite journal | vauthors = Selvakumar P, Sharma RK | title = Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review). | journal = Int J Mol Med | volume = 19 | issue = 5 | pages = 823–7 | year = 2007 | pmid = 17390089 | doi = 10.3892/ijmm.19.5.823| doi-access = free }}
• MARCKS{{cite journal | vauthors = Selvakumar P, Lakshmikuttyamma A, Sharma RK | title = Biochemical characterization of bovine brain myristoyl-CoA:protein N-myristoyltransferase type 2. | journal = J Biomed Biotechnol | volume = 2009 | pages = 907614 | year = 2009 | pmid = 19746168 | doi = 10.1155/2009/907614 | pmc=2737134| doi-access = free }}

• N-myristoyltransferase 1

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• {{cite journal | vauthors = Kolluri SK, Balduf C, Hofmann M, Göttlicher M | title = Novel target genes of the Ah (dioxin) receptor: transcriptional induction of N-myristoyltransferase 2 | journal = Cancer Res. | volume = 61 | issue = 23 | pages = 8534–9 | year = 2002 | pmid = 11731439 }}
• {{cite journal | vauthors = Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, Wilkinson AJ, Holder AA, Tate EW | title = Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach. | url=http://eprints.whiterose.ac.uk/121536/ | journal = Nat Chem | volume = 6 | issue = 2 | pages = 112–21 | year = 2014 | pmid = 24451586 | doi = 10.1038/nchem.1830 | pmc=4739506| bibcode = 2014NatCh...6..112W }}

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• [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/O60551 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Glycylpeptide N-tetradecanoyltransferase 2 (NMT2)

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