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Glypican 4

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Glypican-4 is a protein that in humans is encoded by the GPC4 gene.{{cite journal | vauthors = Veugelers M, Vermeesch J, Watanabe K, Yamaguchi Y, Marynen P, David G | title = GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome | journal = Genomics | volume = 53 | issue = 1 | pages = 1–11 | date = October 1998 | pmid = 9787072 | doi = 10.1006/geno.1998.5465 }}{{cite web | title = Entrez Gene: GPC4 glypican 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2239}}

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.

See also

References

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Further reading

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  • {{cite journal | vauthors = Sheu TJ, Schwarz EM, O'Keefe RJ, Rosier RN, Puzas JE | title = Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae | journal = Journal of Bone and Mineral Research | volume = 17 | issue = 5 | pages = 915–22 | date = May 2002 | pmid = 12009023 | doi = 10.1359/jbmr.2002.17.5.915 | doi-access = free }}
  • {{cite journal | vauthors = Karumanchi SA, Jha V, Ramchandran R, Karihaloo A, Tsiokas L, Chan B, Dhanabal M, Hanai JI, Venkataraman G, Shriver Z, Keiser N, Kalluri R, Zeng H, Mukhopadhyay D, Chen RL, Lander AD, Hagihara K, Yamaguchi Y, Sasisekharan R, Cantley L, Sukhatme VP | title = Cell surface glypicans are low-affinity endostatin receptors | journal = Molecular Cell | volume = 7 | issue = 4 | pages = 811–22 | date = April 2001 | pmid = 11336704 | doi = 10.1016/S1097-2765(01)00225-8 | s2cid = 43358048 | url = https://escholarship.org/content/qt1kx5x9cs/qt1kx5x9cs.pdf?t=oyn3um }}
  • {{cite journal | vauthors = Hagihara K, Watanabe K, Chun J, Yamaguchi Y | title = Glypican-4 is an FGF2-binding heparan sulfate proteoglycan expressed in neural precursor cells | journal = Developmental Dynamics | volume = 219 | issue = 3 | pages = 353–67 | date = November 2000 | pmid = 11066092 | doi = 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1059>3.0.CO;2-# | s2cid = 42594598 }}
  • {{cite journal | vauthors = Veugelers M, Cat BD, Muyldermans SY, Reekmans G, Delande N, Frints S, Legius E, Fryns JP, Schrander-Stumpel C, Weidle B, Magdalena N, David G | title = Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene | journal = Human Molecular Genetics | volume = 9 | issue = 9 | pages = 1321–8 | date = May 2000 | pmid = 10814714 | doi = 10.1093/hmg/9.9.1321 | doi-access = free }}
  • {{cite journal | vauthors = Siebertz B, Stöcker G, Drzeniek Z, Handt S, Just U, Haubeck HD | title = Expression of glypican-4 in haematopoietic-progenitor and bone-marrow-stromal cells | journal = The Biochemical Journal | volume = 344 Pt 3 | pages = 937–43 | date = December 1999 | pmid = 10585884 | pmc = 1220719 | series = 344 | issue = 3 | doi = 10.1042/bj3440937 }}
  • {{cite journal | vauthors = Huber R, Mazzarella R, Chen CN, Chen E, Ireland M, Lindsay S, Pilia G, Crisponi L | title = Glypican 3 and glypican 4 are juxtaposed in Xq26.1 | journal = Gene | volume = 225 | issue = 1–2 | pages = 9–16 | date = December 1998 | pmid = 9931407 | doi = 10.1016/S0378-1119(98)00549-6 | url = https://zenodo.org/record/1260055 }}
  • {{cite journal | vauthors = Watanabe K, Yamada H, Yamaguchi Y | title = K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney | journal = The Journal of Cell Biology | volume = 130 | issue = 5 | pages = 1207–18 | date = September 1995 | pmid = 7657705 | pmc = 2120559 | doi = 10.1083/jcb.130.5.1207 }}

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External links

  • [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=sgbs GeneReviews/NIH/NCBI/UW entry on Simpson-Golabi-Behmel Syndrome]

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