Guadalupe Sabio
{{short description|Spanish biochemist}}
{{Infobox scientist
| name = Guadalupe Sabio
| image = Guadalupe_Sabio.jpg
| birth_date = 4 June 1977
| birth_place = Badajoz
| nationality = Spanish
| alma_mater = University of Extremadura
University of Dundee
| workplaces = Spanish National Cardiovascular Research Centre
Howard Hughes Medical Institute
| website = [http://www.sabiolab.com/ Sabio Lab]
}}
Guadalupe Sabio Buzo (born 4 June 1977) is a Spanish scientist and Professor at the Spanish National Cardiovascular Research Centre, which is part of the Carlos III Health Institute. Her research focuses on stress-activated kinases and the development of diseases associated with obesity. She was awarded the Princess of Girona Foundation Scientist Prize in 2012 and selected as one of the Top 100 Women Leaders in Spain in 2017.
Early life and education
Sabio was born in Badajoz in 1977. She attended the Colegio del Santo Ángel and the Institute of San Fernando.{{Cite web|url=https://www.hoy.es/extremadura/201612/18/vencer-obesidad-puede-dificil-20161218003101-v.html|title=Vencer la obesidad puede ser más difícil que vencer el cáncer|date=2016-12-18|website=Hoy|language=es-ES|access-date=2019-11-03}} She studied veterinary sciences at the University of Extremadura, and graduated in 2000 with an extraordinary award.{{Cite web|url=https://investigacionfjs.com/es/jurado-guadalupe-sabio-buzo/|title=Jurado-Dra. Guadalupe Sabio Buzo|website=Premios a la investigación FJS|language=es-ES|access-date=2019-11-04}} She has said that she chose to study veterinary science as she liked animals very much, and that this could help her understand the origins of diseases. She moved to the United Kingdom for her doctoral studies, where she joined the University of Dundee as a Medical Research Council European graduate student. She completed her doctorate on p38 delta kinases in 2005.{{Cite web|url=https://www.ppu.mrc.ac.uk/about-us/alumni-interviews/guadalupe-sabio|title=Alumni Interview {{!}} Guadalupe Sabio|website=MRC|access-date=2019-11-04}} Whilst her PhD had taught her how to research in vitro, Sabio was keen to translate her research into mouse models. She joined the research group of Roger Davis at the Howard Hughes Medical Institute where she studied the impact of stress on kinases proteins. In 2009 she was awarded Santiago Ramón y Cajal funding to join a biotechnology laboratory in Spain.
Research and career
Sabio joined the Spanish National Cardiovascular Research Centre in 2011.{{Cite web|url=https://www.eldiario.es/tecnologia/cientifica-Guadalupe-Sabio-obeso-ruleta_0_878762172.html|title=La científica Guadalupe Sabio: Estar obeso es jugar a la ruleta rusa|last=EFE|website=eldiario.es|language=es|access-date=2019-11-04}} Sabio is investigating the molecular mechanisms that are associated with obesity, and how they can predispose patients to other conditions such as hepatocellular carcinoma.{{Cite web|url=https://www.publico.es/sociedad/entrevista-guadalupe-sabio-buzo-investigar-perspectiva-genero-basico-salvar-vida-mujeres-prevenir-enfermedades.html|title=Investigar con perspectiva de género es básico para salvar la vida de las mujeres y prevenir enfermedades|website=www.publico.es|access-date=2019-11-03}}{{Cite web|url=https://eldiadigital.es//art/285403/guadalupe-sabio-defiende-el-papel-de-la-grasa-como-organo-endocrino|title=Guadalupe Sabio defiende el papel de la grasa como órgano endocrino|last=ELDIAdigital|first=eldiadigital es|website=eldiadigital.es Periódico de Castilla-La Mancha|language=es|access-date=2019-11-03}} Hepatocellular carcinoma is a type of liver carcinoma, and the second most common cause of cancer-related deaths. Whilst there is chemotherapy available, it can only increase a patient's life by three months. Sabio researches p38gamma, a kinase protein that is expressed excessively in patients with hepatocellular carcinoma, and whether inhibition of this protein could reduce the cancer. She is developing drugs that inhibit p38gamma for the treatment of liver cancer.{{Cite web|url=https://www.redleonardo.es/noticias/descubren-una-nueva-diana-terapeutica-tratar-cancer-higado/|title=Descubren una nueva diana terapéutica para tratar el cáncer de hígado|date=2019-04-10|website=Red Leonardo|language=es|access-date=2019-11-03}} She has also investigated the C-Jun N-terminal kinases (JNK) protein, which is known to control obesity.
She believes that obesity will be a major challenge for future generations, and it should be taken as seriously as smoking.{{Cite web|url=https://www.elmundo.es/ciencia-y-salud/salud/2019/10/27/5db16c4dfdddff1f668b4687.html|title=Guadalupe Sabio: "Hacen falta medidas más drásticas contra la obesidad"|date=2019-10-27|website=ELMUNDO|language=es|access-date=2019-11-03}}{{Cite web|url=https://www.lavanguardia.com/vanguardia-de-la-ciencia/20190317/461077897492/guadalupe-sabio-obesidad-ciencia-videos-seo-ext.html|title=Peligros sobre la obesidad|date=2019-03-17|website=La Vanguardia|access-date=2019-11-04}} By considering fat, adipose tissue, as an endocrine organ she believes people will think more carefully about how to care for it.{{Cite web|url=http://www.uclm.es/noticias/febrero2019/toledo/confeguadalupesabio|title=La investigadora del CNIC Guadalupe Sabio defiende en la UCLM el papel de la grasa como órgano endocrino|last=Mancha|first=Universidad de Castilla-La|website=Universidad de Castilla - La Mancha|access-date=2019-11-04}} She believes that the best antidotes to obesity are exercise and diet.{{Cite news|url=https://elpais.com/elpais/2019/07/18/buenavida/1563460348_213939.html|title=Hay muchas farmacéuticas en busca de la pastilla contra la obesidad. Pero aún no existe nada efectivo|last=Moreno|first=Ana García|date=2019-08-06|work=El País|access-date=2019-11-04|language=es|issn=1134-6582}} In 2017 Sabio was inducted into the European Molecular Biology Organization.{{Cite web|url=https://www.redleonardo.es/noticias/guadalupe-sabio-entra-formar-parte-los-jovenes-mas-brillantes-la-embo/|title=Guadalupe Sabio entra a formar parte de los jóvenes más brillantes de la EMBO|date=2017-11-03|website=Red Leonardo|language=es|access-date=2019-11-03}}
Sabio has been involved in several initiatives to promote women in science.{{Cite web|url=https://www.trendencias.com/mujeres-en-la-ciencia-1/guadalupe-sabio-presencia-minoritaria-mujeres-ciencia-algo-que-esta-empezando-a-corregir-ahora|title=Guadalupe Sabio: "la presencia minoritaria de mujeres en la ciencia es algo que se está empezando a corregir ahora"|last=López|first=Pepa|date=2019-07-19|website=Trendencias|language=es|access-date=2019-11-03}} She has called for more research into the symptoms of disease experienced by women.
Selected publications
- {{Cite journal|title=A stress signalling pathway in adipose tissue regulates hepatic insulin resistance|last=Sabio|first=Guadalupe|date=2008-12-05|journal=Science|volume=322|issue=5907|pages=1539–1543|doi=10.1126/science.1160794|pmid=19056984|pmc=2643026|bibcode=2008Sci...322.1539S }}
- {{Cite journal|title=Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3β Inactivation|last=Sabio|first=Guadalupe|date=2008-05-02|journal=Science|volume=320|issue=5876|pages=667–670|doi=10.1126/science.1156037|pmid=18451303|pmc=2597039|bibcode=2008Sci...320..667T }}
- {{Cite journal|title=TNF and MAP kinase signalling pathways|last=Sabio|first=Guadalupe|date=2014-06-01|journal=Seminars in Immunology|volume=26|issue=3|pages=237–245|doi=10.1016/j.smim.2014.02.009|pmid=24647229|pmc=4099309}}
- {{Cite journal|url=http://www.sabiolab.com/10/2019/nature-p38%ce%b3-cell-cycle-progression-liver-tumorigenesis/|title=p38γ is essential for cell cycle progression and liver tumorigenesis|last=Sabio|first=Guadalupe|date=2019-05-02|journal=Nature|volume=568|issue=7753|pages=557–560|doi=10.1038/s41586-019-1112-8|pmid=30971822|bibcode=2019Natur.568..557T |s2cid=106411585|hdl=20.500.12105/11565|hdl-access=free}}
Awards and honours
- 2020 [https://esci.eu.com/esci-awards/esci-young-investigator-award/ European Society for Clinical Investigation] Young Investigator Award Basic Research.
- 2009 L'Oréal-UNESCO For Women in Science Award{{Cite web|url=http://www.loreal.es/periodistas/notas-de-prensa/2015/apr/las-científicas-españolas-incrementan--su-presencia-en-wikipedia|title=Las científicas españolas incrementan su presencia en Wikipedia - Grupo L'Oréal|website=www.loreal.es|language=es-ES|access-date=2019-11-03}}
- 2012 Princess of Girona Foundation Scientist Prize{{Cite web|url=https://en.fpdgi.org/projects/fpdgi-awards/awards/2012/guadalupe-sabio-2012-fpdgi-scientific-research-award/|title=Guadalupe Sabio, 2012 FPdGi Scientific Research Award|website=en.fpdgi.org|access-date=2019-11-03}}
- 2014 Star of the Community of Madrid{{Cite web|url=https://www.elmundo.es/yodona/2014/03/27/5333e811e2704e760a8b456a.html|title=Guadalupe Sabio: 'La base del éxito es saber fracasar'|date=2014-03-27|website=ELMUNDO|language=es|access-date=2019-11-03}}
- 2014, 2015, 2017 Top 100 Women Leaders
- 2017 European Molecular Biology Organization Leonardo de Biomedicina Fellow
- 2018 AstraZeneca Young Researcher Award{{Cite web|url=https://www.hoy.es/badajoz/pacense-guadalupe-sabio-20180913001012-ntvo.html|title=La pacense Guadalupe Sabio, premiada por una investigación sobre la obesidad|date=2018-09-13|website=Hoy|language=es|access-date=2019-11-03}}
- 2019 Woman to Watch, Science Category{{Cite web|url=https://www.mujeresaseguir.com/social/noticia/1155334048615/nueve-mujeres-sobresalientes-y-recien-nacida-ganadoras-de-premios-mas.1.html|title=Nueve mujeres sobresalientes y una recién nacida, ganadoras de los Premios MAS|date=2019-10-22|website=MAS: Mujeres a seguir|access-date=2019-11-03}}{{Cite web|url=https://www.lavanguardia.com/vida/20191023/471157235420/guadalupe-sabio-ana-pastor-olga-felip-joana-pastrana-sonia-diez-y-mar-gonzalez-galardonadas-en-la-vi-premios-mas.html|title=Guadalupe Sabio, Ana Pastor, Olga Felip, Joana Pastrana, Sonia Díez y Mar González, galardonadas en la VI Premios MAS|date=2019-10-23|website=La Vanguardia|access-date=2019-11-03}}
References
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Category:Spanish women scientists