Guadinomine
Guadinomines are anti-infective compounds produced by Streptomyces sp. K01-0509.{{cite journal | doi = 10.1038/ja.2008.32| pmid = 18503201| title = Guadinomines, Type III Secretion System Inhibitors, Produced by Streptomyces sp. K01-0509| journal = The Journal of Antibiotics| volume = 61| issue = 4| pages = 222–229| year = 2008| last1 = Iwatsuki| first1 = Masato| last2 = Uchida| first2 = Ryuji| last3 = Yoshijima| first3 = Hitomi| last4 = Ui| first4 = Hideaki| last5 = Shiomi| first5 = Kazuro| last6 = Matsumoto| first6 = Atsuko| last7 = Takahashi| first7 = Yoko| last8 = Abe| first8 = Akio| last9 = Tomoda| first9 = Hiroshi| last10 = Ōmura| first10 = Satoshi| doi-access = free}} Guadinomine B is the most potent known inhibitor of the Type III secretion system (TTSS) of Gram-negative bacteria. The guadinomine (gdn) biosynthetic gene cluster includes 26 open reading frames spanning 51.2 kb. Streptomyces sp. K01-0509 produces several derivatives named guadinomines A, B, C1, C2, D, and guadinomic acid.{{Cite journal
| last1 = Holmes | first1 = T. C.
| last2 = May | first2 = A. E.
| last3 = Zaleta-Rivera | first3 = K.
| last4 = Ruby | first4 = J. G.
| last5 = Skewes-Cox | first5 = P.
| last6 = Fischbach | first6 = M. A.
| last7 = Derisi | first7 = J. L.
| last8 = Iwatsuki | first8 = M.
| last9 = Ōmura | first9 = S.
| last10 = Khosla | first10 = C.
| doi = 10.1021/ja308622d
| title = Molecular Insights into the Biosynthesis of Guadinomine: A Type III Secretion System Inhibitor
| journal = Journal of the American Chemical Society
| volume = 134
| issue = 42
| pages = 17797–17806
| year = 2012
| pmid = 23030602
| pmc =3483642
}}