Gunn rat

{{Short description|Mutant rat}}

The Gunn rat, discovered by Charles Kenneth Gunn, was a mutant laboratory rat discovered in 1934 at the Connaught Laboratory in Toronto, Canada. These rats were jaundiced and the defect (a lack of the enzyme uridine diphosphate glucuronyltransferase) was transmitted as an autosomal recessive characteristic. Gunn, a geneticist, bred them at Connaught and later moved to Summerside, Prince Edward Island, Canada, to head up the Canadian Experimental Fox Ranch.{{cite web |title=Crigler-Najjar Syndrome: The Gunn rat |url=http://criglernajjar.altervista.org/treGunn.htm |website=criglernajjar.altervista.org}} The animal model has been used to develop experimental treatments for Crigler–Najjar syndrome.{{Cite journal |last1=Mukherjee |first1=Anil B. |last2=Krasner |first2=Joseph |date=1973 |title=Induction of an Enzyme in Genetically Deficient Rats after Grafting of Normal Liver |url=https://www.jstor.org/stable/1736242 |journal=Science |volume=182 |issue=4107 |pages=68–70 |jstor=1736242 |issn=0036-8075}}{{Cite book |last1=Souba |first1=Wiley W. |url=https://books.google.com/books?id=A3_Ji7vbQ-0C&dq=Gunn+rat&pg=PA624 |title=Surgical Research |last2=Wilmore |first2=Douglas W. |date=2001-01-25 |publisher=Academic Press |isbn=978-0-12-655330-7 |page=624 |language=en}}