Guy R. Cornelis

Cornelis graduated in pharmacist, studied in Oxford, UK and received his PhD from the University of Louvain, Belgium in 1974. He studied antibiotic resistance plasmids in Bristol (UK) and transposons at the University of Freiburg and at the Max Planck Institute in Cologne, Germany. After his appointment as Professor in Louvain in 1984, he investigated bacterial pathogenesis and joined in 1991 the Christian de Duve Institute in Brussels. In 2001, he was appointed Professor of Molecular Microbiology at the Biozentrum, University of Basel, Switzerland. Since emeritus in 2012,{{cite web |url=http://www.biozentrum.unibas.ch/about-us/emeriti/l |title=Emeriti, Biozentrum, University of Basel |work=biozentrum.unibas.ch/ |date= |access-date=2014-01-07}} he pursues his research at the University of Namur, Belgium.{{cite web |url=http://directory.unamur.be/staff/gcorneli |title=Curriculum Vitae |work=unamur.be/ |date= |access-date=2014-01-07}}{{cite web |url=http://www.biozentrum.unibas.ch/news-events/events/past-events/symposium-guy-r-cornelis/biography/ |title=Biography of Guy R. Cornelis |work=biozentrum.unibas.ch |date= |access-date=2014-01-07}}

Cornelis investigates the complex mechanisms of bacterial infectious diseases. He received particular recognition for the co-discovery with H. Wolf-Watz (Umea, Sweden) of the bacterial type III secretion system (T3SS).{{cite journal | pmid =9076724 | volume=23 | title=The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cells | date=31 October 2003 | journal=Molecular Microbiology | pages= 861–867| doi=10.1046/j.1365-2958.1997.2731623.x | last1=Cornelis | first1=Guy R| last2=Wolf-Watz | first2=H | issue=5 | s2cid= 20534412| doi-access=free }}{{cite journal | pmid =17041629 | volume=4 | title=The type III secretion injectisome | date=4 November 2006 | journal=Nat Rev Microbiol | pages= 811–825| doi=10.1038/nrmicro1526| last1=Cornelis | first1=Guy R | issue=11 | s2cid= 29012981}}{{cite journal |url=https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.2012.08146.x |title=Assembly of the Yersinia injectisome: the missing pieces |journal= Molecular Microbiology|date=2012-07-13 |doi=10.1111/j.1365-2958.2012.08146.x |access-date=2022-02-08|last1=Diepold |first1=Andreas |last2=Wiesand |first2=Ulrich |last3=Amstutz |first3=Marlise |last4=Cornelis |first4=Guy R. |volume=85 |issue=5 |pages=878–892 |pmid=22788867 |s2cid=22130173 |doi-access=free }} T3SS is a mechanism by which many bacteria inject a cocktail of toxins, so-called effector proteins into animal, plant or insect cells. The effectors disarm or reprogram the target cell by sabotaging the cellular signaling network. The T3SS apparatus, called injectisome, is a complex nanosyringe made of more than 25 different proteins. Since 2004, Cornelis also studies Capnocytophaga canimorsus, a bacterium from dog's mouths responsible for fatal infections in humans.

{{cite journal | pmid=19307219 | volume=77 | issue=6 | title=Resistance of Capnocytophaga canimorsus to killing by human complement and polymorphonuclear leukocytes | date=June 2009 | journal=Infect. Immun. | doi=10.1128/IAI.01324-08 | last1=Shin | first1=Hwain | last2=Mally | first2=Manuela | last3=Meyer | first3=Salome | last4=Fiechter | first4=Chantal | last5=Paroz | first5=Cécile | last6=Zaehringer | first6=Ulrich | last7=Cornelis | first7=Gus R| pages=2262–2271 | pmc=2687352 }} Cornelis belongs to the world’s most cited scientists.{{cite web | url=http://highlycited.com/names/C.html |title= The people behind the most influential publications |work=highlycited.com/ |date= |access-date=2014-01-07}}{{cite web |url=http://www.urbm.be/home-guy.html |title=Research group Guy R. Cornelis |work=urbm.be/ |access-date=2014-01-07 |url-status=dead |archive-url=https://web.archive.org/web/20131105204308/http://www.urbm.be/home-guy.html |archive-date=2013-11-05 }}

• 1980: Prize of the Belgian Royal Academy of Medicine
• 1985: Pfizer Prize
• 1993: Member of the Belgian Royal Academy of Medicine
• 1998 Elected Member of the European Molecular Biology Organization (EMBO)
• 2008: Member of the American Academy for Microbiology (AAM)

{{reflist}}

• [https://web.archive.org/web/20131105204308/http://www.urbm.be/home-guy.html University of Namur: Guy Cornelis]
• [http://www.biozentrum.unibas.ch/ Biozentrum University of Basel]
• [http://www.narilis.be/ressources/pdf/prof.-guy-cornelis-erc-advanced-investigator-grant ERC Advanced Investigator Grant]
• [https://www.amazon.de/Toxin-The-Cunning-Bacterial-Poisons/dp/0198605587 Book: Toxin – the cunning of bacterial poisons by Alistair Lax]

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{{DEFAULTSORT:Cornelis Guy R}}

Category:Living people

Category:Université catholique de Louvain

Category:University of Freiburg

Category:Members of the European Molecular Biology Organization

Category:Biozentrum University of Basel

Category:Academic staff of the Université de Namur

Category:Year of birth missing (living people)