H2AFB2

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Histone H2A-Bbd type 2/3 also known as H2A Barr body-deficient is a histone protein that in humans is encoded by the H2AFB2 gene (H2A histone family, member B1).{{cite web | title = Entrez Gene: H2A histone family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=474382| accessdate = }}

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the middle copy.

References

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Further reading

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  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |pmc=139241 |doi= 10.1073/pnas.242603899 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |author=Chadwick BP, Willard HF |title=A Novel Chromatin Protein, Distantly Related to Histone H2a, Is Largely Excluded from the Inactive X Chromosome |journal=J. Cell Biol. |volume=152 |issue= 2 |pages= 375–84 |year= 2001 |pmid= 11266453 |pmc=2199617 |doi=10.1083/jcb.152.2.375 }}
  • {{cite journal |vauthors=Bao Y, Konesky K, Park YJ, etal |title=Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA |journal=EMBO J. |volume=23 |issue= 16 |pages= 3314–24 |year= 2004 |pmid= 15257289 |pmc=514500 |doi= 10.1038/sj.emboj.7600316 }}
  • {{cite journal |vauthors=Naylor JA, Buck D, Green P, etal |title=Investigation of the factor VIII intron 22 repeated region (int22h) and the associated inversion junctions |journal=Hum. Mol. Genet. |volume=4 |issue= 7 |pages= 1217–24 |year= 1995 |pmid= 8528212 |doi=10.1093/hmg/4.7.1217 }}

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