H2AFV

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Histone H2A.V is a protein that in humans is encoded by the H2AFV gene.{{cite web | title = Entrez Gene: H2AFV H2A histone family, member V| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=94239| accessdate = }}

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. Several transcripts have been identified for this gene.

References

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Further reading

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  • {{cite journal |vauthors=El Kharroubi A, Piras G, Zensen R, Martin MA |title=Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2535–44 |year= 1998 |pmid= 9566873 |doi= 10.1128/mcb.18.5.2535| pmc=110633 }}
  • {{cite journal | author=Deng L |title=Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones |journal=Virology |volume=277 |issue= 2 |pages= 278–295 |year= 2001 |pmid= 11080476 |doi= 10.1006/viro.2000.0593 |name-list-style=vanc| author2=de la Fuente C | author3=Fu P | display-authors=3 | last4=Wang | first4=L | last5=Donnelly | first5=R | last6=Wade | first6=JD | last7=Lambert | first7=P | last8=Li | first8=H | last9=Lee | first9=CG | doi-access=free }}
  • {{cite journal | author=Deng L |title=Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA |journal=Virology |volume=289 |issue= 2 |pages= 312–326 |year= 2001 |pmid= 11689053 |doi= 10.1006/viro.2001.1129 |name-list-style=vanc| author2=Wang D | author3=de la Fuente C | display-authors=3 | last4=Wang | first4=L | last5=Li | first5=H | last6=Lee | first6=CG | last7=Donnelly | first7=R | last8=Wade | first8=JD | last9=Lambert | first9=P | doi-access=free }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Hillier LW |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–164 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |name-list-style=vanc| author2=Fulton RS | author3=Fulton LA | display-authors=3 | last4=Graves | first4=Tina A. | last5=Pepin | first5=Kymberlie H. | last6=Wagner-Mcpherson | first6=Caryn | last7=Layman | first7=Dan | last8=Maas | first8=Jason | last9=Jaeger | first9=Sara |bibcode=2003Natur.424..157H | doi-access=free }}
  • {{cite journal |vauthors=Lusic M, Marcello A, Cereseto A, Giacca M |title=Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter |journal=EMBO J. |volume=22 |issue= 24 |pages= 6550–6561 |year= 2004 |pmid= 14657027 |doi= 10.1093/emboj/cdg631 | pmc=291826 }}
  • {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
  • {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | author=Oh JH |title=Transcriptome analysis of human gastric cancer |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–954 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 |name-list-style=vanc| author2=Yang JO | author3=Hahn Y | display-authors=3 | last4=Kim | first4=Mi-Rang | last5=Byun | first5=Sang-Soon | last6=Jeon | first6=Yeo-Jin | last7=Kim | first7=Jeong-Min | last8=Song | first8=Kyu-Sang | last9=Noh | first9=Seung-Moo |s2cid=69278 }}
  • {{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |name-list-style=vanc| author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }}
  • {{cite journal |vauthors=Boyne MT, Pesavento JJ, Mizzen CA, Kelleher NL |title=Precise characterization of human histones in the H2A gene family by top down mass spectrometry |journal=J. Proteome Res. |volume=5 |issue= 2 |pages= 248–253 |year= 2006 |pmid= 16457589 |doi= 10.1021/pr050269n }}
  • {{cite journal | author=Kim SC |title=Substrate and functional diversity of lysine acetylation revealed by a proteomics survey |journal=Mol. Cell |volume=23 |issue= 4 |pages= 607–618 |year= 2006 |pmid= 16916647 |doi= 10.1016/j.molcel.2006.06.026 |name-list-style=vanc| author2=Sprung R | author3=Chen Y | display-authors=3 | last4=Xu | first4=Yingda | last5=Ball | first5=Haydn | last6=Pei | first6=Jimin | last7=Cheng | first7=Tzuling | last8=Kho | first8=Yoonjung | last9=Xiao | first9=Hao | doi-access=free }}

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