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HABP2

{{Short description|Mammalian protein found in Homo sapiens}}

{{Infobox_gene}}

Hyaluronan-binding protein 2 also known as factor VII activating protease (FSAP) is a protein that in humans is encoded by the HABP2 gene.{{cite journal |vauthors=Choi-Miura NH, Tobe T, Sumiya J, Nakano Y, Sano Y, Mazda T, Tomita M | title = Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator | journal = J Biochem | volume = 119 | issue = 6 | pages = 1157–65 |date=Dec 1996 | pmid = 8827452 | doi = 10.1093/oxfordjournals.jbchem.a021362}}{{cite journal | author = Romisch J | title = Factor VII activating protease (FSAP): a novel protease in hemostasis | journal = Biol Chem | volume = 383 | issue = 7–8 | pages = 1119–24 |date=Nov 2002 | pmid = 12437095 | doi = 10.1515/BC.2002.121 | s2cid = 37767393 }}{{cite web | title = Entrez Gene: HABP2 hyaluronan binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3026}}

The protein encoded by this gene is an extracellular serine protease which binds hyaluronic acid. It is involved in cell adhesion. The protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. Two transcript variants utilizing alternative polyA sites exist for this gene.

References

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Further reading

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  • {{cite journal |vauthors=Gupta S, Batchu RB, Datta K |title=Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface |journal=Eur. J. Cell Biol. |volume=56 |issue= 1 |pages= 58–67 |year= 1992 |pmid= 1724753 }}
  • {{cite journal | author=Sumiya J |title=Isolation and characterization of the plasma hyaluronan-binding protein (PHBP) gene (HABP2) |journal=J. Biochem. |volume=122 |issue= 5 |pages= 983–90 |year= 1998 |pmid= 9443814 |doi= 10.1093/oxfordjournals.jbchem.a021861|name-list-style=vanc| author2=Asakawa S | author3=Tobe T | display-authors=3 | last4=Hashimoto | first4=K | last5=Saguchi | first5=K | last6=Choi-Miura | first6=NH | last7=Shimizu | first7=Y | last8=Minoshima | first8=S | last9=Shimizu | first9=N }}
  • {{cite journal | author=Choi-Miura NH |title=Identification of the substrates for plasma hyaluronan binding protein |journal=Biol. Pharm. Bull. |volume=24 |issue= 2 |pages= 140–3 |year= 2001 |pmid= 11217080 |doi=10.1248/bpb.24.140 |name-list-style=vanc| author2=Yoda M | author3=Saito K | display-authors=3 | last4=Takahashi | first4=Katsuhiko | last5=Tomita | first5=Motowo |doi-access=free}}
  • {{cite journal | author=Choi-Miura NH |title=Proteolytic activation and inactivation of the serine protease activity of plasma hyaluronan binding protein |journal=Biol. Pharm. Bull. |volume=24 |issue= 5 |pages= 448–52 |year= 2001 |pmid= 11379758 |doi=10.1248/bpb.24.448 |name-list-style=vanc| author2=Takahashi K | author3=Yoda M | display-authors=3 | last4=Saito | first4=Kiyomi | last5=Mazda | first5=Toshio | last6=Tomita | first6=Motowo | doi-access=free }}
  • {{cite journal | author=Roemisch J |title=The frequent Marburg I polymorphism impairs the pro-urokinase activating potency of the factor VII activating protease (FSAP) |journal=Blood Coagul. Fibrinolysis |volume=13 |issue= 5 |pages= 433–41 |year= 2003 |pmid= 12138371 |doi=10.1097/00001721-200207000-00008 |name-list-style=vanc| author2=Feussner A | author3=Nerlich C | display-authors=3 | last4=Stoehr | first4=H.-A. | last5=Weimer | first5=T. |s2cid=39490260 }}
  • {{cite journal | author=Wang KK |title=Novel candidate tumor marker genes for lung adenocarcinoma |journal=Oncogene |volume=21 |issue= 49 |pages= 7598–604 |year= 2002 |pmid= 12386823 |doi= 10.1038/sj.onc.1205953 |name-list-style=vanc| author2=Liu N | author3=Radulovich N | display-authors=3 | last4=Wigle | first4=Dennis A | last5=Johnston | first5=Michael R | last6=Shepherd | first6=Frances A | last7=Minden | first7=Mark D | last8=Tsao | first8=Ming-Sound | doi-access=free }}
  • {{cite journal | author=Etscheid M |title=The hyaluronan-binding serine protease from human plasma cleaves HMW and LMW kininogen and releases bradykinin |journal=Biol. Chem. |volume=383 |issue= 10 |pages= 1633–43 |year= 2003 |pmid= 12452440 |doi=10.1515/BC.2002.184 |name-list-style=vanc| author2=Beer N | author3=Fink E | display-authors=3 | last4=Seitz | first4=R. | last5=Dodt | first5=J. |s2cid=18939354 |url=https://epub.ub.uni-muenchen.de/17849/1/bc.2002.184.pdf}}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Willeit J |title=Marburg I polymorphism of factor VII--activating protease: a prominent risk predictor of carotid stenosis |journal=Circulation |volume=107 |issue= 5 |pages= 667–70 |year= 2003 |pmid= 12578864 |doi=10.1161/01.CIR.0000055189.18831.B1 |name-list-style=vanc| author2=Kiechl S | author3=Weimer T | display-authors=3 | last4=Mair | first4=A | last5=Santer | first5=P | last6=Wiedermann | first6=CJ | last7=Roemisch | first7=J | doi-access=free }}
  • {{cite journal | author=Anderson NL |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources |journal=Mol. Cell. Proteomics |volume=3 |issue= 4 |pages= 311–26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200 |name-list-style=vanc| author2=Polanski M | author3=Pieper R | display-authors=3 | last4=Gatlin | first4=T | last5=Tirumalai | first5=RS | last6=Conrads | first6=TP | last7=Veenstra | first7=TD | last8=Adkins | first8=JN | last9=Pounds | first9=JG | doi-access=free }}
  • {{cite journal | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 10 |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |name-list-style=vanc| author2=Earthrowl ME | author3=Grafham DV | display-authors=3 | last4=Rubenfield | first4=M. | last5=French | first5=L. | last6=Steward | first6=C. A. | last7=Sims | first7=S. K. | last8=Jones | first8=M. C. | last9=Searle | first9=S. |bibcode=2004Natur.429..375D | doi-access=free }}
  • {{cite journal | author=Hoppe B |title=Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism |journal=Blood |volume=105 |issue= 4 |pages= 1549–51 |year= 2005 |pmid= 15486068 |doi= 10.1182/blood-2004-08-3328 |name-list-style=vanc| author2=Tolou F | author3=Radtke H | display-authors=3 | last4=Kiesewetter | first4=H | last5=Dörner | first5=T | last6=Salama | first6=A | doi-access=free}}
  • {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | author=Ireland H |title=The factor VII activating protease G511E (Marburg) variant and cardiovascular risk |journal=Thromb. Haemost. |volume=92 |issue= 5 |pages= 986–92 |year= 2005 |pmid= 15543324 |doi= 10.1160/TH04-05-0275 |name-list-style=vanc| author2=Miller GJ | author3=Webb KE | display-authors=3 | last4=Cooper | first4=JA | last5=Humphries | first5=SE |url=http://discovery.ucl.ac.uk/8111/1/8111.pdf }}
  • {{cite journal | author=Nakazawa F |title=Extracellular RNA is a natural cofactor for the (auto-)activation of Factor VII-activating protease (FSAP) |journal=Biochem. J. |volume=385 |issue= Pt 3 |pages= 831–8 |year= 2005 |pmid= 15654766 |doi= 10.1042/BJ20041021 | pmc=1134760 |name-list-style=vanc| author2=Kannemeier C | author3=Shibamiya A | display-authors=3 | last4=Song | first4=Yutong | last5=Tzima | first5=Eleni | last6=Schubert | first6=Uwe | last7=Koyama | first7=Takatoshi | last8=Niepmann | first8=Michael | last9=Trusheim | first9=Heidi }}
  • {{cite journal | author=van Minkelen R |title=The Marburg I polymorphism of factor VII-activating protease is not associated with venous thrombosis |journal=Blood |volume=105 |issue= 12 |pages= 4898; author reply 4899 |year= 2005 |pmid= 15933067 |doi= 10.1182/blood-2005-02-0576 |name-list-style=vanc| author2=de Visser MC | author3=Vos HL | display-authors=3 | last4=Bertina | first4=RM | last5=Rosendaal | first5=FR |doi-access=free |hdl=1887/5046 |hdl-access=free }}
  • {{cite journal |vauthors=Etscheid M, Beer N, Dodt J |title=The hyaluronan-binding protease upregulates ERK1/2 and PI3K/Akt signalling pathways in fibroblasts and stimulates cell proliferation and migration |journal=Cell. Signal. |volume=17 |issue= 12 |pages= 1486–94 |year= 2006 |pmid= 16153533 |doi= 10.1016/j.cellsig.2005.03.007 }}

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