HACE1

This gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific tagging of target proteins, leading to their subcellular localization or proteasomal degradation. The protein is a potential tumor suppressor and is involved in the pathophysiology of several tumors, including Wilm's tumor. [provided by RefSeq, Mar 2016].

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• {{cite journal |vauthors=Anglesio MS, Evdokimova V, Melnyk N, Zhang L, Fernandez CV, Grundy PE, Leach S, Marra MA, Brooks-Wilson AR, Penninger J, Sorensen PH |title=Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney |journal=Hum. Mol. Genet. |volume=13 |issue=18 |pages=2061–74 |date=September 2004 |pmid=15254018 |doi=10.1093/hmg/ddh215 |doi-access=free }}
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• {{cite journal |vauthors=Einarsdottir E, Bevova MR, Zhernakova A, Monsuur A, Koskinen LL, van't Slot R, Mulder C, Mearin ML, Korponay-Szabo IR, Kaukinen K, Kurppa K, Kere J, Mäki M, Wijmenga C, Saavalainen P |title=Multiple independent variants in 6q21-22 associated with susceptibility to celiac disease in the Dutch, Finnish and Hungarian populations |journal=Eur. J. Hum. Genet. |volume=19 |issue=6 |pages=682–6 |date=June 2011 |pmid=21326284 |pmc=3110053 |doi=10.1038/ejhg.2011.2 }}
• {{cite journal |vauthors=Torrino S, Visvikis O, Doye A, Boyer L, Stefani C, Munro P, Bertoglio J, Gacon G, Mettouchi A, Lemichez E |title=The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1 |journal=Dev. Cell |volume=21 |issue=5 |pages=959–65 |date=November 2011 |pmid=22036506 |doi=10.1016/j.devcel.2011.08.015 |doi-access=free }}
• {{cite journal |vauthors=Castillo-Lluva S, Tan CT, Daugaard M, Sorensen PH, Malliri A |title=The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation |journal=Oncogene |volume=32 |issue=13 |pages=1735–42 |date=March 2013 |pmid=22614015 |doi=10.1038/onc.2012.189 |doi-access=free }}

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