HCO

• Hobart Chamber Orchestra
• Hollywood Chamber Orchestra

• Aldehyde (HCO-)
• Harvard College Observatory
• Hearing carry over, a type of telecommunications relay service
• Heliocentric orbit, an orbit around the Sun
• Holocene climatic optimum

• Handball Club Odense, a Danish handball club
• Hans Christian Ørsted Institute (HCØ)
• Hollister Co., an American lifestyle brand
• National Socialist Society (Russian: {{lang|ru|Национал-социалистическое общество, НСО}})
• Hanwell Community Observatory, a public outreach astronomy organisation; see Hanwell, Oxfordshire
• Hubbard Communications Office, an organization in the Church of Scientology
• Health Care Organization

• The Hong Kong High Court Ordinance.

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