HDF

• Hadfield railway station (station code), Derbyshire, England
• Hauts-de-France, a French region
• Heringsdorf Airport (IATA code), Garz, Germany
• Hôtel-Dieu de France, Lebanon

• Hereditary Disease Foundation, an American organization
• Human Development Foundation, Thailand
• Human Diversity Foundation, a far-right eugenicist organization
• Hungarian Defence Force

• Hierarchical Data Format, a file format
• High-density fiberboard, a wood product
• Hortonworks DataFlow, real-time streaming analytics software
• Hubble Deep Field, an astronomical image
• Hydrodefluorination, a chemical reaction

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