HEBP1
{{Infobox_gene}}
Heme binding protein 1 is a protein that in humans is encoded by the HEBP1 gene.{{cite web | title = Entrez Gene: Heme binding protein 1 | url = https://www.ncbi.nlm.nih.gov/gene/50865 }}
Function
The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells.
References
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Further reading
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- {{cite journal | vauthors = Jacob Blackmon B, Dailey TA, Lianchun X, Dailey HA | title = Characterization of a human and mouse tetrapyrrole-binding protein | journal = Archives of Biochemistry and Biophysics | volume = 407 | issue = 2 | pages = 196–201 | date = Nov 2002 | pmid = 12413491 | doi=10.1016/s0003-9861(02)00471-x}}
- {{cite journal | vauthors = Gao JL, Guillabert A, Hu J, Le Y, Urizar E, Seligman E, Fang KJ, Yuan X, Imbault V, Communi D, Wang JM, Parmentier M, Murphy PM, Migeotte I | title = F2L, a peptide derived from heme-binding protein, chemoattracts mouse neutrophils by specifically activating Fpr2, the low-affinity N-formylpeptide receptor | journal = Journal of Immunology | volume = 178 | issue = 3 | pages = 1450–6 | date = Feb 2007 | pmid = 17237393 | doi=10.4049/jimmunol.178.3.1450| doi-access = free }}
- {{cite journal | vauthors = Micaelo NM, Macedo AL, Goodfellow BJ, Félix V | title = Tetrapyrrole binding affinity of the murine and human p22HBP heme-binding proteins | journal = Journal of Molecular Graphics & Modelling | volume = 29 | issue = 3 | pages = 396–405 | date = Nov 2010 | pmid = 20800521 | doi = 10.1016/j.jmgm.2010.07.008 }}
- {{cite journal | vauthors = Migeotte I, Riboldi E, Franssen JD, Grégoire F, Loison C, Wittamer V, Detheux M, Robberecht P, Costagliola S, Vassart G, Sozzani S, Parmentier M, Communi D | title = Identification and characterization of an endogenous chemotactic ligand specific for FPRL2 | journal = The Journal of Experimental Medicine | volume = 201 | issue = 1 | pages = 83–93 | date = Jan 2005 | pmid = 15623572 | pmc = 2212760 | doi = 10.1084/jem.20041277 }}
- {{cite journal | vauthors = Devosse T, Dutoit R, Migeotte I, De Nadai P, Imbault V, Communi D, Salmon I, Parmentier M | title = Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3 | journal = Journal of Immunology | volume = 187 | issue = 3 | pages = 1475–85 | date = Aug 2011 | pmid = 21709160 | doi = 10.4049/jimmunol.1003545 | doi-access = free | hdl = 2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/114502 | hdl-access = free }}
- {{cite journal | vauthors = Zylka MJ, Reppert SM | title = Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches | journal = Brain Research. Molecular Brain Research | volume = 74 | issue = 1–2 | pages = 175–81 | date = Dec 1999 | pmid = 10640688 | doi=10.1016/s0169-328x(99)00277-6}}
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