HEPACAM2

{{Short description|Protein-coding gene in the species Homo sapiens}}

HEPACAM family member 2 is a protein that in humans is encoded by the HEPACAM2 gene.

{{cite web

| title = Entrez Gene: HEPACAM family member 2

| url = https://www.ncbi.nlm.nih.gov/gene/253012

| accessdate = 2017-09-13

}}

Function

This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology, and apoptosis.

Poly (ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients.

HEPACAM2

Function

References

Further reading