Login
Login

HES5

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{cs1 config|name-list-style=vanc}}

{{Infobox_gene}}

Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene.{{cite journal | vauthors = Takebayashi K, Akazawa C, Nakanishi S, Kageyama R | title = Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element | journal = The Journal of Biological Chemistry | volume = 270 | issue = 3 | pages = 1342–1349 | date = January 1995 | pmid = 7836401 | doi = 10.1074/jbc.270.3.1342 | doi-access = free }}{{cite web | title = Entrez Gene: HES5 hairy and enhancer of split 5 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=388585}}

HES5 regulates the development of the early brain by maintaining stem cell neural progenitors in the ventricular zone.{{cite journal | vauthors = Ohtsuka T, Sakamoto M, Guillemot F, Kageyama R | title = Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain | journal = The Journal of Biological Chemistry | volume = 276 | issue = 32 | pages = 30467–30474 | date = August 2001 | pmid = 11399758 | doi = 10.1074/jbc.M102420200 | doi-access = free }}{{cite journal | vauthors = Hatakeyama J, Bessho Y, Katoh K, Ookawara S, Fujioka M, Guillemot F, Kageyama R | title = Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation | journal = Development | volume = 131 | issue = 22 | pages = 5539–5550 | date = November 2004 | pmid = 15496443 | doi = 10.1242/dev.01436 | doi-access = free | hdl = 2433/144732 | hdl-access = free }} HES5 expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia.{{cite journal | vauthors = Liu J, Ye F, Chen H, Lü W, Zhou C, Xie X | title = Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors | journal = International Journal of Gynecological Cancer | volume = 17 | issue = 6 | pages = 1293–1299 | year = 2007 | pmid = 17388915 | doi = 10.1111/j.1525-1438.2007.00930.x | s2cid = 25609083 | doi-access = free }} Human HES5 gene binds to Notch receptor and expression of HES5 decreases during cartilage differentiation.{{cite journal | vauthors = Karlsson C, Jonsson M, Asp J, Brantsing C, Kageyama R, Lindahl A | title = Notch and HES5 are regulated during human cartilage differentiation | journal = Cell and Tissue Research | volume = 327 | issue = 3 | pages = 539–551 | date = March 2007 | pmid = 17093926 | doi = 10.1007/s00441-006-0307-0 | s2cid = 33749726 }}

References

{{Reflist|2}}

Further reading

{{refbegin | 2}}

  • {{cite journal | vauthors = Gazit R, Krizhanovsky V, Ben-Arie N | title = Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway | journal = Development | volume = 131 | issue = 4 | pages = 903–913 | date = February 2004 | pmid = 14757642 | doi = 10.1242/dev.00982 | doi-access = | s2cid = 44769279 }}
  • {{cite journal | vauthors = Nakatani T, Mizuhara E, Minaki Y, Sakamoto Y, Ono Y | title = Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system | journal = The Journal of Biological Chemistry | volume = 279 | issue = 16 | pages = 16356–16367 | date = April 2004 | pmid = 14764602 | doi = 10.1074/jbc.M311740200 | doi-access = free }}
  • {{cite journal | vauthors = Kamakura S, Oishi K, Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y | title = Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling | journal = Nature Cell Biology | volume = 6 | issue = 6 | pages = 547–554 | date = June 2004 | pmid = 15156153 | doi = 10.1038/ncb1138 | s2cid = 36887899 }}
  • {{cite journal | vauthors = Katoh M, Katoh M | title = Identification and characterization of human HES2, HES3, and HES5 genes in silico | journal = International Journal of Oncology | volume = 25 | issue = 2 | pages = 529–534 | date = August 2004 | pmid = 15254753 | doi = 10.3892/ijo.25.2.529 }}
  • {{cite journal | vauthors = Ohtsuka T, Imayoshi I, Shimojo H, Nishi E, Kageyama R, McConnell SK | title = Visualization of embryonic neural stem cells using Hes promoters in transgenic mice | journal = Molecular and Cellular Neurosciences | volume = 31 | issue = 1 | pages = 109–122 | date = January 2006 | pmid = 16214363 | doi = 10.1016/j.mcn.2005.09.006 | s2cid = 35470002 }}
  • {{cite journal | vauthors = Ong CT, Cheng HT, Chang LW, Ohtsuka T, Kageyama R, Stormo GD, Kopan R | title = Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability | journal = The Journal of Biological Chemistry | volume = 281 | issue = 8 | pages = 5106–5119 | date = February 2006 | pmid = 16365048 | doi = 10.1074/jbc.M506108200 |doi-access=free }}
  • {{cite journal | vauthors = Karlsson C, Brantsing C, Svensson T, Brisby H, Asp J, Tallheden T, Lindahl A | title = Differentiation of human mesenchymal stem cells and articular chondrocytes: analysis of chondrogenic potential and expression pattern of differentiation-related transcription factors | journal = Journal of Orthopaedic Research | volume = 25 | issue = 2 | pages = 152–163 | date = February 2007 | pmid = 17072841 | doi = 10.1002/jor.20287 | doi-access = free }}
  • {{cite journal | vauthors = Karlsson C, Jonsson M, Asp J, Brantsing C, Kageyama R, Lindahl A | title = Notch and HES5 are regulated during human cartilage differentiation | journal = Cell and Tissue Research | volume = 327 | issue = 3 | pages = 539–551 | date = March 2007 | pmid = 17093926 | doi = 10.1007/s00441-006-0307-0 | s2cid = 33749726 }}

{{refend}}

External links

  • {{MeshName|HES5+protein,+human}}

{{NLM content}}

{{Transcription factors|g1}}

Category:Transcription factors

{{gene-1-stub}}