HGFAC
{{short description|Protein-coding gene in humans}}
{{Infobox_gene}}
Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene.{{cite journal |vauthors=Miyazawa K, Shimomura T, Kitamura A, Kondo J, Morimoto Y, Kitamura N | title = Molecular Cloning and Sequence Analysis of the cDNA for a Human Serine Protease Responsible for Activation of Hepatocyte Growth Factor. Structural similarity of the protease precursor to blood coagulation factor XII | journal = J Biol Chem | volume = 268 | issue = 14 | pages = 10024–8 |date=Jun 1993 | doi = 10.1016/S0021-9258(18)82167-6 | pmid = 7683665 | doi-access = free }}{{cite journal |vauthors=Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto Y, Kitamura N | title = Activation of the zymogen of hepatocyte growth factor activator by thrombin | journal = J Biol Chem | volume = 268 | issue = 30 | pages = 22927–32 |date=Dec 1993 | doi = 10.1016/S0021-9258(18)41615-8 | pmid = 8226803 | doi-access = free }}{{cite web | title = Entrez Gene: HGFAC HGF activator| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3083}}
The protein encoded by this gene, belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form.{{cite web | title = Entrez Gene: HGFAC HGF activator| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3083}}
References
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Further reading
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- {{cite journal | author=Nakamura T |title=Structure and function of hepatocyte growth factor. |journal=Prog. Growth Factor Res. |volume=3 |issue= 1 |pages= 67–85 |year= 1992 |pmid= 1838014 |doi=10.1016/0955-2235(91)90014-U }}
- {{cite journal |vauthors=Shimomura T, Ochiai M, Kondo J, Morimoto Y |title=A novel protease obtained from FBS-containing culture supernatant, that processes single chain form hepatocyte growth factor to two chain form in serum-free culture. |journal=Cytotechnology |volume=8 |issue= 3 |pages= 219–29 |year= 1992 |pmid= 1368819 |doi=10.1007/BF02522039 |s2cid=24061579 }}
- {{cite journal |vauthors=Miyazawa K, Shimomura T, Kitamura N |title=Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator. |journal=J. Biol. Chem. |volume=271 |issue= 7 |pages= 3615–8 |year= 1996 |pmid= 8631970 |doi=10.1074/jbc.271.7.3615 |doi-access=free }}
- {{cite journal |vauthors=Shimomura T, Denda K, Kitamura A, etal |title=Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor. |journal=J. Biol. Chem. |volume=272 |issue= 10 |pages= 6370–6 |year= 1997 |pmid= 9045658 |doi=10.1074/jbc.272.10.6370 |doi-access=free }}
- {{cite journal |vauthors=Kawaguchi T, Qin L, Shimomura T, etal |title=Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor. |journal=J. Biol. Chem. |volume=272 |issue= 44 |pages= 27558–64 |year= 1997 |pmid= 9346890 |doi=10.1074/jbc.272.44.27558 |doi-access=free }}
- {{cite journal |vauthors=Miyazawa K, Wang Y, Minoshima S, etal |title=Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene--phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator. |journal=Eur. J. Biochem. |volume=258 |issue= 2 |pages= 355–61 |year= 1999 |pmid= 9874200 |doi=10.1046/j.1432-1327.1998.2580355.x |doi-access=free }}
- {{cite journal |vauthors=Kataoka H, Shimomura T, Kawaguchi T, etal |title=Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 40453–62 |year= 2001 |pmid= 11013244 |doi= 10.1074/jbc.M006412200 |doi-access= free }}
- {{cite journal |vauthors=Kataoka H, Meng JY, Itoh H, etal |title=Localization of hepatocyte growth factor activator inhibitor type 1 in Langhans' cells of human placenta. |journal=Histochem. Cell Biol. |volume=114 |issue= 6 |pages= 469–75 |year= 2001 |pmid= 11201608 |doi= 10.1007/s004180000228 |s2cid=25947109 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Anderson NL, Polanski M, Pieper R, etal |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources. |journal=Mol. Cell. Proteomics |volume=3 |issue= 4 |pages= 311–26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200 |doi-access= free }}
- {{cite journal |vauthors=Tjin EP, Derksen PW, Kataoka H, etal |title=Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator. |journal=Blood |volume=104 |issue= 7 |pages= 2172–5 |year= 2004 |pmid= 15172968 |doi= 10.1182/blood-2003-12-4386 |doi-access= free }}
- {{cite journal |vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 | pmc=2286551 }}
- {{cite journal |vauthors=Shia S, Stamos J, Kirchhofer D, etal |title=Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B. |journal=J. Mol. Biol. |volume=346 |issue= 5 |pages= 1335–49 |year= 2005 |pmid= 15713485 |doi= 10.1016/j.jmb.2004.12.048 }}
- {{cite journal |vauthors=Tjin EP, Groen RW, Vogelzang I, etal |title=Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma. |journal=Blood |volume=107 |issue= 2 |pages= 760–8 |year= 2006 |pmid= 16189274 |doi= 10.1182/blood-2005-05-1929 |doi-access= free }}
- {{cite journal |vauthors=Liu T, Qian WJ, Gritsenko MA, etal |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 }}
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