HIF3A

The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. At least three transcript variants encoding three different isoforms have been found for this gene.{{cite web | title = Entrez Gene: HIF3A hypoxia inducible factor 3, alpha subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64344}}

In rats, it plays a negative role in the adaptation to hypoxia, because the inhibition of HIF-3α expression leads to an increase in physical endurance.{{cite journal | vauthors = Drevytska T, Gavenauskas B, Drozdovska S, Nosar V, Dosenko V, Mankovska I | title = HIF-3α mRNA expression changes in different tissues and their role in adaptation to intermittent hypoxia and physical exercise | journal = Pathophysiology | volume = 19 | issue = 3 | pages = 205–14 | year = 2012 | pmid = 22884965 | doi = 10.1016/j.pathophys.2012.06.002 }}

DNA methylation in the introns of HIF3A is associated with BMI an adiposity.{{cite journal |vauthors=Dick KJ, Nelson CP, Tsaprouni L, Sandling JK, Aïssi D, Wahl S, Meduri E, Morange PE, Gagnon F, Grallert H, Waldenberger M, Peters A, Erdmann J, Hengstenberg C, Cambien F, Goodall AH, Ouwehand WH, Schunkert H, Thompson JR, Spector TD, Gieger C, Trégouët DA, Deloukas P, Samani NJ | title = DNA methylation and body-mass index: a genome-wide analysis. | journal = Lancet | volume = 383 | issue = 9933 | pages = 1990–1998 | year = 2014 | pmid = 24630777 | doi = 10.1016/S0140-6736(13)62674-4 | s2cid = 18026508 | doi-access = free }}

• Hypoxia inducible factors

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• {{cite journal |vauthors=Gu YZ, Moran SM, Hogenesch JB, Wartman L, Bradfield CA | title = Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. | journal = Gene Expr. | volume = 7 | issue = 3 | pages = 205–13 | year = 1998 | pmid = 9840812 | pmc = 6151950 }}
• {{cite journal |vauthors=Makino Y, Kanopka A, Wilson WJ, Tanaka H, Poellinger L | title = Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus. | journal = J. Biol. Chem. | volume = 277 | issue = 36 | pages = 32405–8 | year = 2002 | pmid = 12119283 | doi = 10.1074/jbc.C200328200 | doi-access = free }}
• {{cite journal |vauthors=Maynard MA, Qi H, Chung J, Lee EH, Kondo Y, Hara S, Conaway RC, Conaway JW, Ohh M | title = Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex. | journal = J. Biol. Chem. | volume = 278 | issue = 13 | pages = 11032–40 | year = 2003 | pmid = 12538644 | doi = 10.1074/jbc.M208681200 | doi-access = free }}
• {{cite journal |vauthors=Maynard MA, Evans AJ, Hosomi T, Hara S, Jewett MA, Ohh M | title = Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma. | journal = FASEB J. | volume = 19 | issue = 11 | pages = 1396–406 | year = 2006 | pmid = 16126907 | doi = 10.1096/fj.05-3788com | doi-access = free | s2cid = 86404533 }}
• {{cite journal |vauthors=Jang MS, Park JE, Lee JA, Park SG, Myung PK, Lee DH, Park BC, Cho S | title = Binding and regulation of hypoxia-inducible factor-1 by the inhibitory PAS proteins. | journal = Biochem. Biophys. Res. Commun. | volume = 337 | issue = 1 | pages = 209–15 | year = 2005 | pmid = 16182248 | doi = 10.1016/j.bbrc.2005.09.038 }}
• {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
• {{cite journal |vauthors=Li QF, Wang XR, Yang YW, Lin H | title = Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF-1alpha. | journal = Cell Res. | volume = 16 | issue = 6 | pages = 548–58 | year = 2006 | pmid = 16775626 | doi = 10.1038/sj.cr.7310072 | doi-access = free }}
• {{cite journal |vauthors=Kollers S, Musilova P, Rubes J, Rocha D | title = Comparative mapping reveals multiple rearrangements between pig chromosome 6 and human 19q13. | journal = Anim. Genet. | volume = 37 | issue = 6 | pages = 595–6 | year = 2007 | pmid = 17121608 | doi = 10.1111/j.1365-2052.2006.01516.x }}

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{{Transcription factors|g1}}

Category:Transcription factors

Category:PAS-domain-containing proteins

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