HINT1

{{Short description|Protein-coding gene in the species Homo sapiens}}

Histidine triad nucleotide-binding protein 1 also known as adenosine 5'-monophosphoramidase is an enzyme that in humans is encoded by the HINT1 gene.{{cite journal |vauthors=Brzoska PM, Chen H, Levin NA, Kuo WL, Collins C, Fu KK, Gray JW, Christman MF | title = Cloning, mapping, and in vivo localization of a human member of the PKCI-1 protein family (PRKCNH1) | journal = Genomics | volume = 36 | issue = 1 | pages = 151–6 |date=Feb 1997 | pmid = 8812426 | doi = 10.1006/geno.1996.0435 }}{{cite web | title = Entrez Gene: HINT1 histidine triad nucleotide binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3094}}

HINT1 hydrolyzes purine nucleotide phosphoramidates with a single phosphate group.{{cite journal | vauthors = Strom A, Tong CL, Wagner CR | title = Histidine triad nucleotide-binding proteins HINT1 and HINT2 share similar substrate specificities and little affinity for the signaling dinucleotide Ap4A | journal = FEBS Letters | volume = 594 | issue = 10 | pages = 1497–1505 | date = May 2020 | pmid = 31990367 | doi = 10.1002/1873-3468.13745 | s2cid = 210933742 | doi-access = free }} In addition, functions as scaffolding protein that modulates transcriptional activation.{{cite web | title = P49773: HINT1 (human) | url = https://www.uniprot.org/uniprot/P49773 | work = UniProt }}

It is a haploinsufficient tumor suppressor gene that inhibits the Wnt/β-catenin pathway in colon cancer cells and microphthalmia-associated transcription factor (MITF) activity in human mast cells.{{cite journal |vauthors=Wang L, Li H, Zhang Y, Santella RM, Weinstein IB | title = HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells| journal = Int J Cancer | volume = 124 | issue = 7 | pages = 1526–34|date=Apr 2009 | pmid = 19089909 | pmc = 2667231 | doi = 10.1002/ijc.24072 }}{{cite journal |vauthors=Lee YN, Nechushtan H, Figov N, Razin E | title = The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells | journal = Immunity| volume = 20 | issue = 2 | pages = 145–51 |date=Feb 2004 | pmid = 14975237 | doi =10.1016/S1074-7613(04)00020-2 | doi-access = free }} In the LysRS-Ap4A-MITF signaling pathway, HINT1 inhibits the MITF transcriptional activity by direct association. Upon pathway activation, HINT1 is released from MITF by diadenosine tetraphosphate (Ap4A), produced by LysRS.{{cite journal |vauthors=Yannay-Cohen N, Carmi-Levy I, Kay G, Yang CM, Han JM, Kemeny DM, Kim S, Nechushtan H, Razin E | title = LysRS serves as a key signaling molecule in the immune response by regulating gene expression | journal = Mol Cell| volume = 34 | issue = 5 | pages = 603–11 |date=June 2009 | pmid = 19524539 | doi =10.1016/j.molcel.2009.05.019 | doi-access = free }}

References

{{cite journal |vauthors=Brzoska PM, Chen H, Zhu Y, etal |title=The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 17 |pages= 7824–8 |year= 1995 |pmid= 7644499 |doi=10.1073/pnas.92.17.7824 | pmc=41238 |bibcode=1995PNAS...92.7824B |doi-access=free }}
{{cite journal |vauthors=Lima CD, Klein MG, Weinstein IB, Hendrickson WA |title=Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 11 |pages= 5357–62 |year= 1996 |pmid= 8643579 |doi=10.1073/pnas.93.11.5357 | pmc=39250 |bibcode=1996PNAS...93.5357L |doi-access=free }}
{{cite journal |vauthors=Lima CD, Klein MG, Hendrickson WA |title=Structure-based analysis of catalysis and substrate definition in the HIT protein family. |journal=Science |volume=278 |issue= 5336 |pages= 286–90 |year= 1997 |pmid= 9323207 |doi=10.1126/science.278.5336.286 }}
{{cite journal |vauthors=Klein MG, Yao Y, Slosberg ED, etal |title=Characterization of PKCI and comparative studies with FHIT, related members of the HIT protein family. |journal=Exp. Cell Res. |volume=244 |issue= 1 |pages= 26–32 |year= 1998 |pmid= 9770345 |doi= 10.1006/excr.1998.4153 |doi-access= free }}
{{cite book |vauthors=Weitzdoerfer R, Stolzlechner D, Dierssen M, etal |chapter=Reduction of nucleoside diphosphate kinase B, Rab GDP- dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down Syndrome brain |title=Protein Expression in Down Syndrome Brain |journal=Journal of Neural Transmission. Supplementum |issue= 61 |pages= 347–59 |year= 2002 |pmid= 11771757 |doi= 10.1007/978-3-7091-6262-0_29|isbn=978-3-211-83704-7 }}
{{cite journal |vauthors=Bieganowski P, Garrison PN, Hodawadekar SC, etal |title=Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. |journal=J. Biol. Chem. |volume=277 |issue= 13 |pages= 10852–60 |year= 2002 |pmid= 11805111 |doi= 10.1074/jbc.M111480200 | pmc=2556056 |doi-access=free }}
{{cite journal | author=Brenner C |title=Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases. |journal=Biochemistry |volume=41 |issue= 29 |pages= 9003–14 |year= 2002 |pmid= 12119013 |doi=10.1021/bi025942q | pmc=2571077 }}
{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
{{cite journal |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |s2cid=23783563 }}
{{cite journal |vauthors=Galey D, Becker K, Haughey N, etal |title=Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes. |journal=J. Neurovirol. |volume=9 |issue= 3 |pages= 358–71 |year= 2003 |pmid= 12775419 |doi=10.1080/13550280390201119 |s2cid=22016092 }}
{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
{{cite journal |vauthors=Weiske J, Huber O |title=The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity. |journal=J. Biol. Chem. |volume=281 |issue= 37 |pages= 27356–66 |year= 2006 |pmid= 16835243 |doi= 10.1074/jbc.M513452200 |doi-access= free }}
{{cite journal |vauthors=Ajit SK, Ramineni S, Edris W, etal |title=RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling. |journal=Cell. Signal. |volume=19 |issue= 4 |pages= 723–30 |year= 2007 |pmid= 17126529 |doi= 10.1016/j.cellsig.2006.09.008 }}
{{cite journal | vauthors= Symes AJ, Eilertsen M, Millar M|title=Quantitative Analysis of BTF3, HINT1, NDRG1 and ODC1 Protein Over-Expression in Human Prostate Cancer Tissue |journal=PLOS ONE |volume=8 |issue=12 |pages= e84295 |year= 2013 |pmid= 24386364|doi= 10.1371/journal.pone.0084295 |pmc=3874000|bibcode=2013PLoSO...884295S |display-authors=etal|doi-access=free }}

HINT1

See also

References

Further reading