HIP2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Ubiquitin-conjugating enzyme E2 K is a protein that in humans is encoded by the UBE2K gene.{{cite journal | vauthors = Kalchman MA, Graham RK, Xia G, Koide HB, Hodgson JG, Graham KC, Goldberg YP, Gietz RD, Pickart CM, Hayden MR | title = Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme | journal = J Biol Chem | volume = 271 | issue = 32 | pages = 19385–94 | date = Sep 1996 | pmid = 8702625 | doi = 10.1074/jbc.271.32.19385 | doi-access = free }}{{cite journal | vauthors = Christensen DE, Brzovic PS, Klevit RE | title = E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages | journal = Nat Struct Mol Biol | volume = 14 | issue = 10 | pages = 941–8 | date = Oct 2007 | pmid = 17873885 | doi = 10.1038/nsmb1295 | s2cid = 32160828 }}{{cite web | title = Entrez Gene: HIP2 huntingtin interacting protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3093}}

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.

Interactions

HIP2 has been shown to interact with Huntingtin{{cite journal | vauthors = Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME | title = Huntingtin interacts with a family of WW domain proteins | journal = Hum. Mol. Genet. | volume = 7 | issue = 9 | pages = 1463–74 | date = Sep 1998 | pmid = 9700202 | doi = 10.1093/hmg/7.9.1463 | doi-access = free }} and RNF2.{{cite journal | vauthors = Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S | title = E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme | journal = FEBS Lett. | volume = 503 | issue = 1 | pages = 61–4 | date = Aug 2001 | pmid = 11513855 | doi = 10.1016/S0014-5793(01)02689-8 | s2cid = 42977319 | doi-access = }}

References

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Further reading

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  • {{cite journal | vauthors = Petersén A, Mani K, Brundin P | title = Recent advances on the pathogenesis of Huntington's disease. | journal = Exp. Neurol. | volume = 157 | issue = 1 | pages = 1–18 | year = 1999 | pmid = 10222105 | doi = 10.1006/exnr.1998.7006 | s2cid = 12974652 }}
  • {{cite journal | vauthors = Coux O, Goldberg AL | title = Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor kappaB1. | journal = J. Biol. Chem. | volume = 273 | issue = 15 | pages = 8820–8 | year = 1998 | pmid = 9535861 | doi = 10.1074/jbc.273.15.8820 | doi-access = free }}
  • {{cite journal | vauthors = Whitby FG, Xia G, Pickart CM, Hill CP | title = Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes. | journal = J. Biol. Chem. | volume = 273 | issue = 52 | pages = 34983–91 | year = 1999 | pmid = 9857030 | doi = 10.1074/jbc.273.52.34983 | doi-access = free }}
  • {{cite journal | vauthors = Kikuchi J, Furukawa Y, Kubo N, Tokura A, Hayashi N, Nakamura M, Matsuda M, Sakurabayashi I | title = Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis. | journal = Arterioscler. Thromb. Vasc. Biol. | volume = 20 | issue = 1 | pages = 128–34 | year = 2000 | pmid = 10634809 | doi = 10.1161/01.ATV.20.1.128 | doi-access = free }}
  • {{cite journal | vauthors = Furukawa Y, Kubo N, Kikuchi J, Tokura A, Fujita N, Sakurabayashi I | title = Regulation of macrophage-specific gene expression by degenerated lipoproteins. | journal = Electrophoresis | volume = 21 | issue = 2 | pages = 338–46 | year = 2000 | pmid = 10675012 | doi = 10.1002/(SICI)1522-2683(20000101)21:2<338::AID-ELPS338>3.0.CO;2-9 | s2cid = 22857626 }}
  • {{cite journal | vauthors = Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S | title = E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme. | journal = FEBS Lett. | volume = 503 | issue = 1 | pages = 61–4 | year = 2001 | pmid = 11513855 | doi = 10.1016/S0014-5793(01)02689-8 | s2cid = 42977319 | doi-access = }}
  • {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. | journal = Nat. Biotechnol. | volume = 21 | issue = 5 | pages = 566–9 | year = 2004 | pmid = 12665801 | doi = 10.1038/nbt810 | s2cid = 23783563 }}
  • {{cite journal|author23-link=Bernhard Landwehrmeyer | vauthors = Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Büssow K, Buessow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG, Lehrach H, Wanker EE | title = A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. | journal = Mol. Cell | volume = 15 | issue = 6 | pages = 853–65 | year = 2004 | pmid = 15383276 | doi = 10.1016/j.molcel.2004.09.016 | doi-access = free }}
  • {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
  • {{cite journal | vauthors = Flierman D, Coleman CS, Pickart CM, Rapoport TA, Chau V | title = E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 31 | pages = 11589–94 | year = 2006 | pmid = 16868077 | pmc = 1520313 | doi = 10.1073/pnas.0605215103 | bibcode = 2006PNAS..10311589F | doi-access = free }}
  • {{cite journal | vauthors = de Pril R, Fischer DF, Roos RA, van Leeuwen FW | title = Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases. | journal = Mol. Cell. Neurosci. | volume = 34 | issue = 1 | pages = 10–9 | year = 2007 | pmid = 17092742 | doi = 10.1016/j.mcn.2006.09.006 | s2cid = 9704303 }}
  • {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry. | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}

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