HIPK1

The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.

HIPK1 has been shown to interact with P53.{{cite journal | vauthors = Kondo S, Lu Y, Debbas M, Lin AW, Sarosi I, Itie A, Wakeham A, Tuan J, Saris C, Elliott G, Ma W, Benchimol S, Lowe SW, Mak TW, Thukral SK | title = Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1) | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 9 | pages = 5431–6 | date = Apr 2003 | pmid = 12702766 | pmc = 154362 | doi = 10.1073/pnas.0530308100 | bibcode = 2003PNAS..100.5431K | doi-access = free }}

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• {{cite journal | vauthors = Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 3 | pages = 169–76 | date = Jun 1998 | pmid = 9734811 | doi = 10.1093/dnares/5.3.169 | doi-access = free }}
• {{cite journal | vauthors = Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y | title = Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors | journal = The Journal of Biological Chemistry | volume = 273 | issue = 40 | pages = 25875–9 | date = Oct 1998 | pmid = 9748262 | doi = 10.1074/jbc.273.40.25875 | doi-access = free }}
• {{cite journal | vauthors = Ecsedy JA, Michaelson JS, Leder P | title = Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity | journal = Molecular and Cellular Biology | volume = 23 | issue = 3 | pages = 950–60 | date = Feb 2003 | pmid = 12529400 | pmc = 140690 | doi = 10.1128/MCB.23.3.950-960.2003 }}
• {{cite journal | vauthors = Kondo S, Lu Y, Debbas M, Lin AW, Sarosi I, Itie A, Wakeham A, Tuan J, Saris C, Elliott G, Ma W, Benchimol S, Lowe SW, Mak TW, Thukral SK | title = Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1) | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 9 | pages = 5431–6 | date = Apr 2003 | pmid = 12702766 | pmc = 154362 | doi = 10.1073/pnas.0530308100 | bibcode = 2003PNAS..100.5431K | doi-access = free }}
• {{cite journal | vauthors = Song JJ, Lee YJ | title = Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization | journal = The Journal of Biological Chemistry | volume = 278 | issue = 47 | pages = 47245–52 | date = Nov 2003 | pmid = 12968034 | doi = 10.1074/jbc.M213201200 | doi-access = free }}
• {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = Jul 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
• {{cite journal | vauthors = Li X, Zhang R, Luo D, Park SJ, Wang Q, Kim Y, Min W | title = Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation | journal = The Journal of Biological Chemistry | volume = 280 | issue = 15 | pages = 15061–70 | date = Apr 2005 | pmid = 15701637 | doi = 10.1074/jbc.M414262200 | doi-access = free }}

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