HIST1H1T
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Histone H1t is a protein that in humans is encoded by the HIST1H1T gene.{{cite journal |vauthors=Koppel DA, Wolfe SA, Fogelfeld LA, Merchant PS, Prouty L, Grimes SR | title = Primate testicular histone H1t genes are highly conserved and the human H1t gene is located on chromosome 6 | journal = J Cell Biochem | volume = 54 | issue = 2 | pages = 219–30 |date=Jun 1994 | pmid = 8175896 | doi = 10.1002/jcb.240540210 | s2cid = 13648109 }}{{cite journal |vauthors=Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ | title = The human and mouse replication-dependent histone genes | journal = Genomics | volume = 80 | issue = 5 | pages = 487–98 |date=Oct 2002 | pmid = 12408966 | doi =10.1016/S0888-7543(02)96850-3 }}{{cite web | title = Entrez Gene: HIST1H1T histone cluster 1, H1t| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3010}}
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
References
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Further reading
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- {{cite journal |vauthors=Drabent B, Kardalinou E, Doenecke D |title=Structure and expression of the human gene encoding testicular H1 histone (H1t) |journal=Gene |volume=103 |issue= 2 |pages= 263–8 |year= 1991 |pmid= 1889752 |doi=10.1016/0378-1119(91)90284-I }}
- {{cite journal |vauthors=Albig W, Drabent B, Kunz J, etal |title=All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6 |journal=Genomics |volume=16 |issue= 3 |pages= 649–54 |year= 1993 |pmid= 8325638 |doi= 10.1006/geno.1993.1243 }}
- {{cite journal |vauthors=Albig W, Kioschis P, Poustka A, etal |title=Human histone gene organization: nonregular arrangement within a large cluster |journal=Genomics |volume=40 |issue= 2 |pages= 314–22 |year= 1997 |pmid= 9119399 |doi= 10.1006/geno.1996.4592 }}
- {{cite journal |vauthors=Malanga M, Atorino L, Tramontano F, etal |title=Poly(ADP-ribose) binding properties of histone H1 variants |journal=Biochim. Biophys. Acta |volume=1399 |issue= 2–3 |pages= 154–60 |year= 1998 |pmid= 9765591 |doi= 10.1016/s0167-4781(98)00110-9}}
- {{cite journal |vauthors=Steger K, Klonisch T, Gavenis K, etal |title=Expression of mRNA and protein of nucleoproteins during human spermiogenesis |journal=Mol. Hum. Reprod. |volume=4 |issue= 10 |pages= 939–45 |year= 1999 |pmid= 9809674 |doi=10.1093/molehr/4.10.939 |doi-access= }}
- {{cite journal |vauthors=Wellman SE, Song Y, Mamoon NM |title=Sequence preference of mouse H1(0) and H1t |journal=Biochemistry |volume=38 |issue= 40 |pages= 13112–8 |year= 1999 |pmid= 10529182 |doi=10.1021/bi9914917 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
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