HIST1H2AC

HIST1H2AC gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.{{cite journal | vauthors = Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F | title = Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes. | journal = J Cell Physiol | volume = 230| issue = 4 | pages = 802–812 | date = April 2015 | pmid = 25205602 | doi = 10.1002/jcp.24808| hdl = 11392/2066612 | s2cid = 24986454 | hdl-access = free }} For this reason, HIST1H2AC is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.

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