HLA-B70
{{Short description|Human leukocyte antigen serotype}}
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| colspan="3" | Image:HLA-B.png |
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| colspan="3" color="white" | HLA-B (alpha)-β2MG with bound peptide |
| align="center" colspan="3" | major histocompatibility complex (human), class I, B70 |
| bgcolor="#e7dcc3" | Alleles
| colspan = 2 bgcolor="#eeeeee" | *1503, *1509, *1510, |
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| colspan="3" bgcolor="#dddddd" | Structure (See HLA-B) |
| colspan="2" bgcolor="#dddddd" | Shared data |
| bgcolor="#e7dcc3" | Locus
| bgcolor="#eeeeee" | chr.6 [https://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=6p21.31 6p21.31] |
HLA-B70 (B70) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.{{cite journal |pmc=2848993 |year=2010 |last1=Marsh |first1=S. G. |title=Nomenclature for factors of the HLA system, 2010 |journal=Tissue Antigens |volume=75 |issue=4 |pages=291–455 |last2=Albert |first2=E. D. |last3=Bodmer |first3=W. F. |last4=Bontrop |first4=R. E. |last5=Dupont |first5=B. |last6=Erlich |first6=H. A. |last7=Fernández-Viña |first7=M. |last8=Geraghty |first8=D. E. |last9=Holdsworth |first9=R. |last10=Hurley |first10=C. K. |last11=Lau |first11=M. |last12=Lee |first12=K. W. |last13=Mach |first13=B. |last14=Maiers |first14=M. |last15=Mayr |first15=W. R. |last16=Müller |first16=C. R. |last17=Parham |first17=P. |last18=Petersdorf |first18=E. W. |last19=Sasazuki |first19=T. |last20=Strominger |first20=J. L. |last21=Svejgaard |first21=A. |last22=Terasaki |first22=P. I. |last23=Tiercy |first23=J. M. |last24=Trowsdale |first24=J. |pmid=20356336 |doi=10.1111/j.1399-0039.2010.01466.x }}
B70 is one of many split antigens of the broad antigen, B15.
Serotype
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|+ Serotypes B15, B62, B63, B70, B71, B72, B75, B76, B77 recognition of the | ||||||||||
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| style="width:50px" | B*15 | style="width:50px" | B15
| style="width:50px" | B62 | style="width:50px" | B63
| style="width:50px" | B70 | style="width:50px" | B71 | style="width:50px" | B72
| style="width:50px" | B75 | style="width:50px" | B76 | style="width:50px" | B77 | style="width:50px" | Sample | |||
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| allele | % | % | % | % | % | % | % | % | % | size (N) |
| style = "background:#e8e8f8" | {{Asterisk}}1503 | 1 | 61 | 10 | 2569 | ||||||
| style = "background:#e8e8f8" | {{Asterisk}}1509 | 53 | 65 | ||||||||
| style = "background:#e8e8f8" | {{Asterisk}}1510 | 1 | 49 | 2 | 2 | 1 | 1204 | ||||
| style = "background:#e8e8f8" | {{Asterisk}}1518 | 51 | 3 | 552 | |||||||
| style = "background:#e8e8f8" | {{Asterisk}}1529 | 19 | 21 | ||||||||
| style = "background:#e8e8f8" | {{Asterisk}}1537 | 30 | 34 | ||||||||
| colspan = 10 | Alleles link-out to IMGT/HLA Databease at EBI |
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Alleles
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|+ HLA B*1503 frequencies | ||
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| | freq | |
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| ref. | align="left" |Population | style="width:50px" | (%) |
| {{cite journal |vauthors=Middleton D, Menchaca L, Rood H, Komerofsky R | title = New allele frequency database | journal = Tissue Antigens | volume = 61 | issue = 5 | pages = 403–7 | year = 2003 | pmid = 12753660 | doi =10.1034/j.1399-0039.2003.00062.x | doi-access = free }} | align="left"|Burkina Faso Rimaibe | 13.8 |
| align="left"|Guinea Bissau | 10.8 | |
| align="left"|Cameroon Pygmy Baka | 10.0 | |
| align="left"|South African Natal Zulu | 9.5 | |
| align="left"|Kenya Luo | 8.9 | |
| align="left"|Ivory Coast Akan Adiopodoume | 8.0 | |
| align="left"|Kenya Nandi | 7.9 | |
| align="left"|Cameroon Sawa | 7.7 | |
| align="left"|Zimbabwe Harare Shona | 7.7 | |
| align="left"|USA African America | 7.3 | |
| align="left"|Burkina Faso Fulani | 7.1 | |
| align="left"|Mali Bandiagara | 6.9 | |
| align="left"|Senegal Niokholo Mandenka | 6.9 | |
| align="left"|Cape Verde SE Islands | 6.5 | |
| align="left"|Kenya | 6.3 | |
| align="left"|Uganda Kampala | 6.2 | |
| align="left"|Sudanese | 6.0 | |
| align="left"|Zambia Lusaka | 5.7 | |
| align="left"|Cameroon Yaounde | 4.9 | |
| align="left"|Cape Verde NW Islands | 4.8 | |
| align="left"|Oman | 4.7 | |
| align="left"|Cameroon Bamileke | 4.5 | |
| align="left"|Tunisia Tunis | 4.5 | |
| align="left"|Cameroon Beti | 3.7 | |
| align="left"|Brazil Belo Horizonte | 3.2 | |
| align="left"|Azores Terceira Island | 2.4 | |
| align="left"|Madeira | 2.2 | |
| align="left"|Saudi Arabia Guraiat and Hail | 2.0 | |
| align="left"|Tunisia | 2.0 | |
| align="left"|United Arab Emerates | 1.5 | |
| align="left"|Brazil | 1.4 | |
| align="left"|Cuban White | 1.4 | |
| align="left"|Morocco Nador Metalsa | 1.4 | |
| align="left"|Mexico Mestizos | 1.2 | |
| align="left"|Italy Bergamo | 1.1 | |
| align="left"|Portugal North | 1.1 | |
| align="left"|American Samoa | 1.0 | |
| align="left"|Iran Baloch | 1.0 | |
| align="left"|Mexico Guadalajara Mestizos (2) | 1.0 | |
| align="left"|Azores Central Islands | 0.9 | |
| align="left"|Israel Ashk. and Non-Ashk. Jews | 0.9 | |
| align="left"|Taiwan Hakka | 0.9 | |
| align="left"|Croatia | 0.7 |
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