HLA-DOA
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{{Short description|Protein-coding gene in the species Homo sapiens}}
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HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene.{{cite journal |vauthors=Young JA, Trowsdale J | title = The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA transcript | journal = Immunogenetics | volume = 31 | issue = 5–6 | pages = 386–8 |date=Aug 1990 | pmid = 2370084 | doi =10.1007/BF02115015 | s2cid = 31652916 }}{{cite web | title = Entrez Gene: HLA-DOA major histocompatibility complex, class II, DO alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3111}}
HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.
References
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Further reading
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- {{cite journal |vauthors=Piatier-Tonneau D, Gastinel LN, Amblard F, etal |title=Interaction of CD4 with HLA class II antigens and HIV gp120 |journal=Immunogenetics |volume=34 |issue= 2 |pages= 121–8 |year= 1991 |pmid= 1869305 |doi=10.1007/BF00211424 |s2cid=10116507 }}
- {{cite journal |vauthors=Rosenstein Y, Burakoff SJ, Herrmann SH |title=HIV-gp120 can block CD4-class II MHC-mediated adhesion |journal=J. Immunol. |volume=144 |issue= 2 |pages= 526–31 |year= 1990 |doi=10.4049/jimmunol.144.2.526 |pmid= 1967269 }}
- {{cite journal |vauthors=Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ |title=Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 22 |pages= 9052–6 |year= 1991 |pmid= 1978941 |doi=10.1073/pnas.87.22.9052 | pmc=55099 |doi-access=free }}
- {{cite journal |vauthors=Rosen-Bronson S, Long EO |title=An unusual form of alternative splicing in the HLA-DNA gene |journal=Immunogenetics |volume=33 |issue= 2 |pages= 124–31 |year= 1991 |pmid= 1999352 |doi=10.1007/BF00210826 |s2cid=23451770 }}
- {{cite journal |vauthors=Jonsson AK, Rask L |title=Human class II DNA and DOB genes display low sequence variability |journal=Immunogenetics |volume=29 |issue= 6 |pages= 411–3 |year= 1989 |pmid= 2499532 |doi=10.1007/BF00375872 |s2cid=5481750 }}
- {{cite journal |vauthors=Clayton LK, Sieh M, Pious DA, Reinherz EL |title=Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding |journal=Nature |volume=339 |issue= 6225 |pages= 548–51 |year= 1989 |pmid= 2543930 |doi= 10.1038/339548a0 |bibcode=1989Natur.339..548C |s2cid=4246781 |doi-access=free }}
- {{cite journal |vauthors=Diamond DC, Sleckman BP, Gregory T, etal |title=Inhibition of CD4+ T cell function by the HIV envelope protein, gp120 |journal=J. Immunol. |volume=141 |issue= 11 |pages= 3715–7 |year= 1988 |doi=10.4049/jimmunol.141.11.3715 |pmid= 2846691 }}
- {{cite journal |vauthors=Inoko H, Ando A, Kimura M, Tsuji K |title=Isolation and characterization of the cDNA clone and genomic clones of a new HLA class II antigen heavy chain, DO alpha |journal=J. Immunol. |volume=135 |issue= 3 |pages= 2156–9 |year= 1985 |doi=10.4049/jimmunol.135.3.2156 |pmid= 2991382 }}
- {{cite journal |vauthors=Trowsdale J, Kelly A |title=The human HLA class II alpha chain gene DZ alpha is distinct from genes in the DP, DQ and DR subregions |journal=EMBO J. |volume=4 |issue= 9 |pages= 2231–7 |year= 1986 |pmid= 3000765 |doi= 10.1002/j.1460-2075.1985.tb03919.x| pmc=554490 }}
- {{cite journal |vauthors=Andrieu JM, Even P, Venet A |title=AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications |journal=AIDS Research |volume=2 |issue= 3 |pages= 163–74 |year= 1986 |pmid= 3489470 |doi= 10.1089/aid.1.1986.2.163}}
- {{cite journal |vauthors=Houlgatte R, Scarmato P, el Marhomy S, etal |title=HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4 |journal=J. Immunol. |volume=152 |issue= 9 |pages= 4475–88 |year= 1994 |doi=10.4049/jimmunol.152.9.4475 |pmid= 7512597 |doi-access=free }}
- {{cite journal |vauthors=Chirmule N, McCloskey TW, Hu R, etal |title=HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71) |journal=J. Immunol. |volume=155 |issue= 2 |pages= 917–24 |year= 1995 |doi=10.4049/jimmunol.155.2.917 |pmid= 7541827 }}
- {{cite journal |vauthors=Rowell JF, Stanhope PE, Siliciano RF |title=Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC |journal=J. Immunol. |volume=155 |issue= 1 |pages= 473–88 |year= 1995 |doi=10.4049/jimmunol.155.1.473 |pmid= 7602119 |s2cid=19994352 }}
- {{cite journal |vauthors=Chen YH, Böck G, Vornhagen R, etal |title=HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41 |journal=Mol. Immunol. |volume=31 |issue= 13 |pages= 977–82 |year= 1994 |pmid= 8084338 |doi=10.1016/0161-5890(94)90092-2 }}
- {{cite journal |vauthors=Chirmule N, Wang XP, Hu R, etal |title=Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help |journal=Cell. Immunol. |volume=155 |issue= 1 |pages= 169–82 |year= 1994 |pmid= 8168144 |doi= 10.1006/cimm.1994.1110 |doi-access= free }}
- {{cite journal |vauthors=Callahan KM, Rowell JF, Soloski MJ, etal |title=HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes |journal=J. Immunol. |volume=151 |issue= 6 |pages= 2928–42 |year= 1993 |doi=10.4049/jimmunol.151.6.2928 |pmid= 8376762 }}
- {{cite journal |vauthors=Liljedahl M, Kuwana T, Fung-Leung WP, etal |title=HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport |journal=EMBO J. |volume=15 |issue= 18 |pages= 4817–24 |year= 1996 |pmid= 8890155 |doi= 10.1002/j.1460-2075.1996.tb00862.x| pmc=452218 }}
- {{cite journal |vauthors=Ruff AL, Guarnieri FG, Staveley-O'Carroll K, etal |title=The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8671–8 |year= 1997 |pmid= 9079699 |doi=10.1074/jbc.272.13.8671 |doi-access=free }}
- {{cite journal |vauthors=Douek DC, Altmann DM |title=HLA-DO is an intracellular class II molecule with distinctive thymic expression |journal=Int. Immunol. |volume=9 |issue= 3 |pages= 355–64 |year= 1997 |pmid= 9088974 |doi=10.1093/intimm/9.3.355 |doi-access=free }}
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