HLA-DPB1
{{Short description|Protein-coding gene in the species Homo sapiens}}
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HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene.
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.{{cite web | title = Entrez Gene: HLA-DPB1 major histocompatibility complex, class II, DP beta 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3115}}
See also
References
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Further reading
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- {{cite journal | author=Mitsunaga S |title=Family study on HLA-DPB1 polymorphism: linkage analysis with HLA-DR/DQ and two "new" alleles |journal=Hum. Immunol. |volume=34 |issue= 3 |pages= 203–11 |year= 1992 |pmid= 1358867 |doi=10.1016/0198-8859(92)90113-2 | author2=Kuwata S | author3=Tokunaga K | last4=Uchikawa | first4=Chieko | last5=Takahashi | first5=Koki | last6=Akaza | first6=Tatsuya | last7=Mitomi | first7=Yoshitada | last8=Juji | first8=Takeo }}
- {{cite journal |vauthors=Marsh SG, Bodmer JG |title=HLA class II nucleotide sequences, 1992 |journal=Tissue Antigens |volume=40 |issue= 5 |pages= 229–43 |year= 1993 |pmid= 1362295 |doi=10.1111/j.1399-0039.1992.tb02050.x }}
- {{cite journal |vauthors=Eiermann TH, Uhl S, Fakler J, Goldmann SF |title=A novel HLA-DPB1 sequence, DPB1*2301 |journal=Tissue Antigens |volume=40 |issue= 2 |pages= 108–10 |year= 1992 |pmid= 1412416 |doi=10.1111/j.1399-0039.1992.tb01969.x }}
- {{cite journal |vauthors=Korioth F, Hartung K, Deicher H, Frey J |title=A new HLA-DPB1 allele from a patient with systemic lupus erythematosus |journal=Tissue Antigens |volume=39 |issue= 4 |pages= 216–9 |year= 1992 |pmid= 1529429 |doi=10.1111/j.1399-0039.1992.tb01938.x }}
- {{cite journal | author=de Koster HS |title=Positive correlation between oligonucleotide typing and T-cell recognition of HLA-DP molecules |journal=Immunogenetics |volume=34 |issue= 1 |pages= 12–22 |year= 1991 |pmid= 1713190 |doi=10.1007/BF00212307 | author2=Kenter MJ | author3=D'Amaro J | last4=Luiten | first4=R. M. | last5=Schroeijers | first5=W. E. M. | last6=Giphart | first6=M. J. | last7=Termijtelen | first7=A. |s2cid=21845822 }}
- {{cite journal | author=Vanderbeeken YE |title=Modulation of the HLA class II antigen at a molecular level by maternal serum among cord blood cells and unrelated lymphocytes |journal=Arch. Gynecol. Obstet. |volume=248 |issue= 4 |pages= 199–209 |year= 1991 |pmid= 1832848 |doi=10.1007/BF02390359 | author2=Duchateau J | author3=Colle H | last4=Gregoire | first4=M. | last5=Desseilles | first5=P. | last6=Lucas | first6=A. |s2cid=25184115 }}
- {{cite journal | author=Piatier-Tonneau D |title=Interaction of CD4 with HLA class II antigens and HIV gp120 |journal=Immunogenetics |volume=34 |issue= 2 |pages= 121–8 |year= 1991 |pmid= 1869305 |doi=10.1007/BF00211424 | author2=Gastinel LN | author3=Amblard F | last4=Wojcik | first4=Marianne | last5=Vaigot | first5=Pierre | last6=Auffray | first6=Charles |s2cid=10116507 }}
- {{cite journal |vauthors=Rosenstein Y, Burakoff SJ, Herrmann SH |title=HIV-gp120 can block CD4-class II MHC-mediated adhesion |journal=J. Immunol. |volume=144 |issue= 2 |pages= 526–31 |year= 1990 |doi=10.4049/jimmunol.144.2.526 |pmid= 1967269 |doi-access=free }}
- {{cite journal |vauthors=Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ |title=Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 22 |pages= 9052–6 |year= 1991 |pmid= 1978941 |doi=10.1073/pnas.87.22.9052 | pmc=55099 |doi-access=free }}
- {{cite journal |vauthors=Bugawan TL, Begovich AB, Erlich HA |title=Rapid HLA-DPB typing using enzymatically amplified DNA and nonradioactive sequence-specific oligonucleotide probes |journal=Immunogenetics |volume=32 |issue= 4 |pages= 231–41 |year= 1990 |pmid= 2242906 |doi=10.1007/BF00187094 |s2cid=39873046 }}
- {{cite journal | author=Lair B |title=A newly characterized HLA-DP beta-chain allele. Evidence for DP beta heterogeneity within the DPw4 specificity |journal=J. Immunol. |volume=141 |issue= 4 |pages= 1353–7 |year= 1988 |pmid= 2456351 | author2=Alber C | author3=Yu WY | last4=Watts | first4=R | last5=Bahl | first5=M | last6=Karr | first6=RW |doi=10.4049/jimmunol.141.4.1353 | doi-access=free}}
- {{cite journal | author=Bugawan TL |title=Analysis of HLA-DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP-alpha and DP-beta loci |journal=J. Immunol. |volume=141 |issue= 11 |pages= 4024–30 |year= 1988 |pmid= 2460556 | author2=Horn GT | author3=Long CM | last4=Mickelson | first4=E | last5=Hansen | first5=JA | last6=Ferrara | first6=GB | last7=Angelini | first7=G | last8=Erlich | first8=HA |doi=10.4049/jimmunol.141.11.4024 | doi-access=free }}
- {{cite journal | author=Begovich AB |title=A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 23 |pages= 9489–93 |year= 1990 |pmid= 2512583 |doi=10.1073/pnas.86.23.9489 | pmc=298522 | author2=Bugawan TL | author3=Nepom BS | last4=Klitz | first4=W | last5=Nepom | first5=GT | last6=Erlich | first6=HA |doi-access=free }}
- {{cite journal | author=Scholl P |title=Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 11 |pages= 4210–4 |year= 1989 |pmid= 2542966 |doi=10.1073/pnas.86.11.4210 | pmc=287420 | author2=Diez A | author3=Mourad W | last4=Parsonnet | first4=J | last5=Geha | first5=RS | last6=Chatila | first6=T |doi-access=free |bibcode=1989PNAS...86.4210S }}
- {{cite journal |vauthors=Clayton LK, Sieh M, Pious DA, Reinherz EL |title=Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding |journal=Nature |volume=339 |issue= 6225 |pages= 548–51 |year= 1989 |pmid= 2543930 |doi= 10.1038/339548a0 |bibcode=1989Natur.339..548C |s2cid=4246781 |doi-access=free }}
- {{cite journal | author=Lee JS |title=Sequence polymorphism of HLA-DP beta chains |journal=Immunogenetics |volume=29 |issue= 5 |pages= 346–9 |year= 1989 |pmid= 2714855 |doi=10.1007/BF00352845 | author2=Sartoris S | author3=Briata P | last4=Choi | first4=Ed | last5=Cullen | first5=Constance | last6=Lepaslier | first6=Denis | last7=Yunis | first7=Ivan |s2cid=13414587 }}
- {{cite journal |vauthors=Compagnone-Post P, Turco E, Robinson C, Trucco M |title=The beta-chains of DP4 molecules from different haplotypes are encoded by the same gene |journal=Genomics |volume=2 |issue= 1 |pages= 8–13 |year= 1988 |pmid= 2838415 |doi=10.1016/0888-7543(88)90103-6 }}
- {{cite journal | author=Diamond DC |title=Inhibition of CD4+ T cell function by the HIV envelope protein, gp120 |journal=J. Immunol. |volume=141 |issue= 11 |pages= 3715–7 |year= 1988 |pmid= 2846691 | author2=Sleckman BP | author3=Gregory T | last4=Lasky | first4=LA | last5=Greenstein | first5=JL | last6=Burakoff | first6=SJ |doi=10.4049/jimmunol.141.11.3715 | doi-access=free}}
- {{cite journal | author=Ando A |title=Isolation and allelic polymorphism of cDNA clones and genomic clones of HLA-DP heavy and light chains |journal=Hum. Immunol. |volume=17 |issue= 3 |pages= 355–67 |year= 1987 |pmid= 2878910 |doi=10.1016/0198-8859(86)90286-7 | author2=Inoko H | author3=Kimura M | last4=Ogata | first4=Sachie | last5=Tsuji | first5=Kimiyoshi }}
- {{cite journal |vauthors=Kelly A, Trowsdale J |title=Complete nucleotide sequence of a functional HLA-DP beta gene and the region between the DP beta 1 and DP alpha 1 genes: comparison of the 5' ends of HLA class II genes |journal=Nucleic Acids Res. |volume=13 |issue= 5 |pages= 1607–21 |year= 1985 |pmid= 2987832 |doi=10.1093/nar/13.5.1607 | pmc=341099 }}
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{{Surface antigens}}
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